Fijación con sutura frente a sellante de fibrina en hernioplastia con prótesis reabsorbible (ácido poliglicólico y carbonato trimetileno). Estudio experimental en animales / Mesh fixation with sutures versus fibrin sealant in hernioplasty with re-absorbable prosthesis (polyglycolic acid and trimethylene carbonate). Experimental study in animals

Introducción Dado que estudios actuales han mostrado la validez de la fijación atraumática con cola de fibrina (Tissucol®) frente a las suturas convencionales con malla de polipropileno, en este trabajo se quiere estudiar el comportamiento en las mallas reabsorbibles. Material y métodos Se utilizaron 20 ratas blancas Wistar. Se realizaron 2 defectos herniarios en la pared abdominal, que se repararon de forma preperitoneal con malla reabsorbible de ácido poliglicólico y carbonato trimetileno, en el lado de la derecha la malla se fijó con Tissucol® y en el lado de la izquierda se fijó con sutura convencional fijada a la fascia muscular. Se sacrificaron 10 ratas a los 14 días (serie A) y el resto a los 28 días (serie B). Se emplearon para comprobar la contingencia de la pared abdominal 2 test; el test de presión: neumoperitoneo mayor de 40mmHg mantenido durante 1min, y el test de tracción: dinamometría de la zona afectada mayor de 300g de tracción por cm2. Se analizó la pared abdominal para determinar la integración de la malla de nueva generación. Resultados La fijación de la malla tras los test de presión y de tracción no evidenció alteraciones estadísticamente significativas en los 2 grupos. La integración de la malla fue mayor en los casos de fijación con cola de fibrina, donde se observó un aumento del número de neovasos. Conclusiones La fijación con colas biológicas de fibrina equiparó a la convencional. La malla reabsorbible se integró adecuadamente y se comprobó que tanto la neoformación vascular como la propia integración de la malla es más notable al aplicar el sellante de fibrina que con la sutura convencional. (AU)

Introduction Current studies have shown the validity of the atraumatic fixation with fibrin glue (Tissucol®) compared to conventional sutures in polypropylene mesh fixation. We propose to study the behaviour of absorbable mesh. Material and methods We used 20 Wistar white rats. Two hernia defects were made in the abdominal wall, which were repaired using absorbable PGA-TMC preperitoneal mesh. The right side of the mesh was fixed with Tissucol and left side with conventional suture attached to the muscle fascia. One group of 10 rats were sacrificed at day 14 (Series A) and the other 10 rats at 28 days (Series B). We used two tests to assess the contingency of the abdominal wall; Pressure Test: pneumoperitoneum more than 40mmHg maintained for 1min, Traction Test: dynamometry of the affected area more than 300mg per cm2 of traction. Abdominal wall was analysed to determine the integration of the new generation mesh. Results The fixation of the mesh after the pressure and traction tests showed no statistically significant changes in either group. The integration of the mesh and vessel neoformation was higher in the cases of fixation with fibrin glue. Conclusions Biological fixation with fibrin glue is similar to the conventional. Absorbable mesh was suitably integrated and vascular neoformation and integration of the mesh was also found to be better than conventional sutures when fibrin sealant was applied (AU)

Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair.

PURPOSE: The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair. METHODS: Ten pigs were included in this study. The abdomens of the animals were opened by means of a median subumbilical laparotomy to place four prostheses that were cut into square pieces of 4 x 4 cm. The two prostheses in the most cephalic position were polypropylene meshes, and the other two prostheses in a more caudal position were expanded polytetrafluoroethylene prostheses (Dualmesh Plus Corduroy). The prostheses on the right side of each animal were previously impregnated with fibrin glue. After 5 weeks, the animals were reoperated on to assess the quantity and quality (consistency) of the adhesions. RESULTS: There were fewer intraperitoneal adhesions and they were more labile in the case of prostheses impregnated with fibrin glue. Moreover, we also observed that in many of the animals the polypropylene mesh did not show any adhesions, although polypropylene has been considered to be a typical adhesion producing material. CONCLUSIONS: Fibrin glue reduces both the quantity and consistency of adhesions, even in the case of polypropylene meshes.

[Prevention of peritoneal adhesions to intraperitoneal prostheses. An experimental study in pigs]. / Prevención de adherencias peritoneales a las prótesis intraperitoneales. Estudio experimental en cerdos.

INTRODUCTION: The aim of this study was to investigate the effect of fibrin glue and hyaluronidase gel on the prevention of postoperative peritoneal adhesions to intraperitoneal prostheses. MATERIAL AND METHOD: Twenty pigs, divided in two groups, were included. In all animals, four implants (4 x 4 cm) were placed: two polypropylene mesh implants were placed in an upper location and two polytetrafluoroethylene (PTFE) implants (Dualmesh Plus Corduroy) were placed in a lower position. Implants located in the right side of the animals were painted with fibrin glue (group A, n = 10) or with hyaluronidase gel (group B, n = 10). After 5 weeks, the animals were sacrificed and the results (number and grade of intraperitoneal adhesions, histological data on prosthesis integration, such as mesothelialization, fibroblast infiltration, vessel neoformation, etc.) were evaluated. RESULTS: Intraperitoneal adhesions decreased in implants painted with fibrin glue and hyaluronidase gel compared with untreated implants. When right-sided adhesions formed, they were looser and in many animals, the implants were completely peritonized. Integration of the prostheses was not affected by either fibrin glue or hyaluronidase gel. CONCLUSIONS: Adhesion formation can be reduced after abdominal surgery. The reduction achieved in this study was greater in the quantity than in the consistency of the adhesions. The results with hyaluronidase gel were moderately superior to those obtained with fibrin glue. Hyaluronidase gel has the advantage of being inexpensive.

Prevención de adherencias peritoneales a las prótesis intraperitoneales. Estudio experimental en cerdos / Prevention of peritoneal adhesions to intraperitoneal prostheses. An experimental study in pigs

Introducción. El objetivo de este estudio es investigar el efecto de la cola de fibrina y del gel de hialuronidasa en la prevención de adherencias peritoneales a las prótesis intraperitoneales. Material y método. En este estudio hemos utilizado 20 cerdos, divididos en 2 grupos: en todos los animales se procedió a colocar implantes de 4 x 4 cm: 2 de malla de polipropileno en una posición más cefálica, y otros dos de politetrafluoroetileno (Dualmesh® Plus Corduroy) en una posición más caudal. Los implantes situados en el lado derecho del animal se impregnaron de inhibidores de la producción de adherencias (en 10 animales se utilizó cola de fibrina, serie A, y en otros 10 se utilizó gel de hialuronidasa, serie B). Después de 5 semanas, se procedió al sacrificio de los animales y se evaluaron los resultados (cantidad y calidad de las adherencias formadas, así como datos histológicos de integración de las prótesis, como mesotelización infiltración por fibroblastos, vasos neoformados, etc.). Resultados. Al cabo de 5 semanas se apreciaba que los implantes impregnados de sustancias inhibidoras de la producción de adherencias presentaban menos adherencias, éstas (cuando existían) eran más laxas, e incluso en muchos casos los implantes estaban perfectamente peritonizados. La integración de las prótesis no estaba afectada por la presencia de los inhibidores. Conclusiones. La formación de adherencias puede disminuirse tras la cirugía abdominal. La disminución conseguida es mayor en la cantidad que en la consistencia de adherencias. Los resultados son algo mejores en la serie en la que se utilizó hialuronidasa que en la que se utilizó cola de fibrina. La hialuronidasa tiene la ventaja de tener un menor coste (AU)

Introduction. The aim of this study was to investigate the effect of fibrin glue and hyaluronidase gel on the prevention of postoperative peritoneal adhesions to intraperitoneal prostheses. Material and method. Twenty pigs, divided in two groups, were included. In all animals, four implants (4 x 4 cm) were placed: two polypropylene mesh implants were placed in an upper location and two polytetrafluoroethylene (PTFE) implants (Dualmesh Plus Corduroy) were placed in a lower position. Implants located in the right side of the animals were painted with fibrin glue (group A, n = 10) or with hyaluronidase gel (group B, n = 10). After 5 weeks, the animals were sacrificed and the results (number and grade of intraperitoneal adhesions, histological data on prosthesis integration, such as mesothelialization, fibroblast infiltration, vessel neoformation, etc.) were evaluated. Results. Intraperitoneal adhesions decreased in implants painted with fibrin glue and hyaluronidase gel compared with untreated implants. When right-sided adhesions formed, they were looser and in many animals, the implants were completely peritonized. Integration of the prostheses was not affected by either fibrin glue or hyaluronidase gel. Conclusions. Adhesion formation can be reduced after abdominal surgery. The reduction achieved in this study was greater in the quantity than in the consistency of the adhesions. The results with hyaluronidase gel were moderately superior to those obtained with fibrin glue. Hyaluronidase gel has the advantage of being inexpensive (AU)

[Analysis of the Spanish National Registry of Laparoscopic Pancreatic Surgery]. / Análisis del Registro Nacional Español de la Cirugía Laparoscópica del Páncreas.

INTRODUCTION: The reported experience with laparoscopic pancreatic surgery remains limited to case reports or small series of patients. A recent European multicenter study has allowed the limits and results of this technique to be known. This article presents an analysis of the results of the Spanish National Registry of Laparoscopic Pancreatic Surgery. MATERIAL AND METHODS: A total of 132 patients with lesions in the left pancreas were included in this series. The final diagnosis included 42 neuroendocrine tumors, 40 cystic neoplasms, 24 cysts and pseudocysts, 8 inflammatory tumors, 8 ductal carcinomas, 7 intraductal papillary mucinous tumors, 1 acinar carcinoma and 2 solid pseudopapillary tumors. RESULTS: The conversion rate was 9.7%. Tumor enucleation was performed only in patients with insulinomas. The most frequent technique was spleen-preserving distal pancreatectomy. There were no postoperative deaths. The overall rate of postoperative pancreatic-related complications was 16%. CONCLUSIONS: Although only a few Spanish hospitals participated in the registry, a greater number of hospitals are expected to enroll patients in the very near future.

Análisis del Registro Nacional Español de la Cirugía Laparoscópica del Páncreas / Analysis of the Spanish National Registry of Laparoscopic Pancreatic Surgery

Introducción. En el pasado, la experiencia de la cirugía laparoscópica del páncreas se mantenía limitada a experiencias individuales con un reducido núcleo de pacientes. El reciente estudio multicéntrico europeo ha permitido conocer los límites y los resultados de la técnica. En este trabajo se presenta el análisis de los resultados del Registro Nacional Español de la Cirugía Laparoscópica del Páncreas (RNEP). Material y métodos. Se ha incluido a 132 pacientes con lesiones localizadas en el páncreas izquierdo: 42 tumores neuroendocrinos, 40 neoplasias quísticas, 24 quistes y seudoquistes, 8 tumores inflamatorios, 8 carcinomas ductales, 7 neoplasias papilares mucinosa, 1 carcinoma acinar, 2 tumores sólidos seudopapilares. Resultados. El índice de conversión fue del 9,7%. La técnica de enucleación se realizó tan sólo en pacientes portadores de un insulinoma. La pancreatectomía distal con preservación esplénica fue la utilizada con más frecuencia. La mortalidad fue nula y, como morbilidad, la fístula pancreática apareció en el 16% de los casos. Conclusiones. A pesar de que el número de hospitales españoles es limitado, los resultados obtenidos hacen esperar una mayor experiencia en un futuro próximo (AU)

Introduction. The reported experience with laparoscopic pancreatic surgery remains limited to case reports or small series of patients. A recent European multicenter study has allowed the limits and results of this technique to be known. This article presents an analysis of the results of the Spanish National Registry of Laparoscopic Pancreatic Surgery. ¡ Material and methods. A total of 132 patients with lesions in the left pancreas were included in this series. The final diagnosis included 42 neuroendocrine tumors, 40 cystic neoplasms, 24 cysts and pseudocysts, 8 inflammatory tumors, 8 ductal carcinomas, 7 intraductal papillary mucinous tumors, 1 acinar carcinoma and 2 solid pseudopapillary tumors. Results. The conversion rate was 9.7%. Tumor enucleation was performed only in patients with insulinomas. The most frequent technique was spleen-preserving distal pancreatectomy. There were no postoperative deaths. The overall rate of postoperative pancreatic-related complications was 16%. Conclusions. Although only a few Spanish hospitals participated in the registry, a greater number of hospitals are expected to enroll patients in the very near future (AU)

Laparoscopic ventral hernia repair without sutures--double crown technique: our experience after 140 cases with a mean follow-up of 40 months.

It has been reported that avoidance of recurrences after laparoscopic ventral hernia repair (LVHR) depends on using sutures to secure the mesh. We developed a successful sutureless LVHR. The "Double Crown" LVHR using ePTFE mesh (overlap, 23 cm) was done in 140 cases. Tacks were placed 1 cm apart at the edge of the mesh. A second crown of tacks was placed at the edge of the defect. Three conversions (2.14%) and five bowel perforations occurred intraoperatively (3.57%). Postoperative complications were prolonged ileus (two cases), hematoma (two cases), seroma requiring drainage (three cases), and reoperation in one case for mesh intolerance, three cases for bowel perforation, and one case for small bowel ischemia. The recurrence rate (mean follow-up of 40 months) was 2.14%. The Double Crown LVHR is a safe alternative to LVHR using sutures, with a similar recurrence rate, less pain, fewer incisions and infections, and a shorter operating time.

Cirugía laparoscópica de órganos sólidos / Laroscopic surgery of solid organs

No disponible

Perfil de los tutores de un gran hospital universitario / Profile of the tutors of a large university hospital

Introducción: La tutoría es poco utilizada en España. La Conferencia Mundial sobre Enseñanza de la Medicina ha recalcado su importancia. El objetivo de este trabajo es conocer la situación actual, como base para definir cuáles deben ser las características del tutor ideal. Material y métodos: En los Hospitales Universitarios Virgen del Rocío, Sevilla, que cuentan con 326 residentes y 54 tutores, se pasó en 1999 un cuestionario a los tutores. Se recibieron 42 respuestas (78 per cent), realizándose análisis simple. Resultados: La edad media de los encuestados era de 47 años. De ellos, 34 (81 per cent) eran varones y 17 (41 per cent) doctores. La universidad de origen era la de Sevilla en 27 (64 per cent) y la de Granada en tres (7 per cent). El hospital Virgen del Rocío era el hospital de origen en 27 casos (64 per cent) y el Virgen Macarena en 8 (19 per cent). Tenían una experiencia como especialista superior a 15 años 30 encuestados (71 per cent); de 11 a 15 años, 7 (17 per cent); de 6 a 10 años, 4 (9 per cent) e inferior a 6 años, uno (2 per cent). En cuanto a la experiencia como tutor, era superior a 15 años en dos entrevistados (5 per cent); de 11 a 15 años en uno (2 per cent); de 6 a 10 años en 13 (31 per cent) e inferior a 6 años en 26 (62 per cent). Plantilla: 28 (67 per cent); adjuntos: 30 (71 per cent); jefes sección: 11 (26 per cent); jefe servicio: 1 (2 per cent). Las carencias sentidas según los encuestados eran compensaciones y reconocimiento (42; 100 per cent); recursos docentes (42; 100 per cent); tiempo (41; 98 per cent), y colaboración (6; 14 per cent). En cuanto a la cualificación de las carencias (0: mínimo; 10: máximo), el reconocimiento obtuvo 8,0; las ayudas docentes, 7,7; el tiempo, 7,5; las compensaciones, 6,1, y la colaboración, 5,7. La puntuación de la autovaloración fue de 7,6 en los resultados globales; de 6,8 en la programación; de 6,7 en la cumplimentación de actividades, y de 4,9 en la investigación. Conclusiones: a) reconocer la actividad de los tutores; b) disponer de tiempo para desarrollar sus funciones; c) darles formación en metodología docente, y d) concienciar a los hospitales sobre la docencia e investigación (AU)