Trichlorfon for treatment of cutaneous habronemosis - evaluation of intravenous regional perfusion in the distal equine limbs

Background: Equine cutaneous habronemiasis is common in the distal regions of the limbs. Organophosphates, appliedsystemically, one previously used treatment, which is highly effective, but currently in disuse, due to the risks of intoxication. Regional perfusion is a potential technique for distal limb wounds, since, in addition to being used in low doses, itprevents systemic circulation of the drug and possible intoxication, and has a lower treatment cost. The current work aimedto perform clinical, laboratory, and venography evaluations of the use of trichlorfon in regional intravenous perfusion, asa possible form of treatment for cutaneous habronemosis in the distal region of equine limbs.Materials, Methods & Results: Twelve equines were used, divided into 2 groups, with the left thoracic limb (LTL) beingthe test limb, and the right thoracic limb (RTL) the control limb. At moment zero (M0), distal radiography and venographywere performed. The tourniquet was then loosened and after 5 min, at moment one (M1), the tourniquet was repositionedfor 1.25 mg/kg (G1) and 5.5 mg/kg (G2) trichlorfon injections into the left thoracic limb, diluted in 20 mL of Ringer’s lactate solution, and 20 mL of Ringer’s lactate solution was applied to the right thoracic limb. The tourniquet was maintainedfor 30 min after infusion in both groups. At moment 2 (M2), 4 days later, blood tests, radiography, and venography wererepeated. Every day between M0 and M2, physical examinations were performed, including measurement of the pastern,fetlock, and coronet band, and a lameness examination. There were no significant alterations in clinical parameters, behavior, and appetite. In the blood cell count, there was an increase in leukocytes on D4 in G2, although remaining withinthe reference values for the species. The biochemical tests showed no alterations. There were no changes in the circumferences evaluated and 4 equines from G2 presented lameness in the LTL and...

Downer cow syndrome causing rhabdomyolysis and acute renal failure in a 17-month-old Guzerá heifer / Síndrome da vaca caída causando rabdomiólise e insuficiência renal aguda em uma novilha Guzerá de 17 meses

The downer cow syndrome (DCS) is characterized by an alert cow showing inability or reluctance to stand for 12 hours or more. This paper reported clinical, laboratory, and pathological findings in a Guzerá heifer with rhabdomyolysis, pigmenturia and acute renal failure following DCS. A 17-month-old Guzerá heifer was transported via a 350-km ride in a truck and showed sternal recumbency and severe difficulty in standing and walking. Neurological examination was unremarkable, and the heifer presented normal response to cranial nerves and spinal cord tests. Rectal palpation revealed a 5-month gravid uterus. No other abnormalities were noted in the pelvis or around the coxofemoral joints. Biochemical abnormalities included extremely high muscular enzyme activities (creatine phosphokinase and aspartate aminotransferase) and high creatinine levels. Urinalysis revealed blackish and cloudy urine, proteinuria, and a positive occult blood test. Spinal cord ultrasonography showed no abnormalities. This report highlighted an uncommon clinical presentation (myoglobinuria) and pathological findings in a heifer with DCS as a consequence of severe compressive muscle damage. Practitioners and producers must be aware of the risk of careless road transportation for long distances of cattle, especially obese cows, avoiding unnecessary suffering and expenses due to DCS.

A síndrome da vaca caída (SVC) é caracterizada por um bovino alerta que mostra incapacidade ou relutância em permanecer em estação por 12 horas ou mais. O objetivo deste trabalho é relatar os achados clínicos, laboratoriais e patológicos em uma novilha Guzerá com rabdomiólise, pigmentúria e insuficiência renal aguda após a SVC. Uma novilha da raça Guzerá, de 17 meses de idade, foi transportada de caminhão por 350 km e apresentou decúbito esternal, grande dificuldade para assumir estação e caminhar. O exame neurológico não demonstrou alterações, e a novilha possuía resposta normal aos testes de nervos cranianos e medula espinhal. A palpação retal revelou útero grávido de cinco meses. Nenhuma outra anormalidade foi observada na pelve ou na região das articulações coxofemorais. As anormalidades bioquímicas incluíram atividades de enzimas musculares (creatina fosfoquinase e aspartato aminotransferase) extremamente aumentadas e níveis elevados de creatinina. A urinálise revelou urina enegrecida e turva, proteinúria e teste de sangue oculto positivo. O exame ultrassonográfico da medula espinhal não apresentou anormalidades. Este relato evidencia uma apresentação clínica (mioglobinúria) e achados patológicos incomuns em uma novilha com SVC em consequência de extensa lesão muscular compressiva. Veterinários e produtores devem estar atentos aos riscos do transporte rodoviário descuidado por longas distâncias de bovinos, especialmente vacas obesas, evitando assim sofrimento e despesas desnecessárias decorrentes da SVC.

Forelimb amputation and long-term follow-Up in a female donkey

Background: Limb amputation may be a life-saving procedure for animals and minimally impact their comfort and qualityof life, as previously reported in pets. This procedure is an appropriate alternative to euthanasia when catastrophic injury toa limb prevents its successful restoration. In horses, limb amputation has been performed for the past 40 years. Althoughin the reviewed literature there are no scientific reports of limb amputation in donkeys. This paper aimed to report a successful forelimb amputation and long-term follow-up in a female donkey.Case: A 10-month-old and 95 kg female Nordestino donkey was evaluated for a wound with bone exposition on the leftforelimb. Physical examination revealed that the donkey was alert with moderate body condition score, tachycardia, tachypnea, and a medial wound revealing the necrotic aspect of the left radius. Radiographic examination presented Salter-Harristype 1 exposed radius fracture. Hematology revealed normocytic and normochromic anemia, and hyperfibrinogenemia.Due to the catastrophic injury and no forecast for building a prosthesis, the donkey underwent general anesthesia for leftforelimb amputation through the midhumerus diaphysis. A fish-mouth skin incision was performed on the midhumerus,the underlying musculature was dissected and the vessels ligated until the bone could be accessed. Then, a sterile sawwire was used to transect it, and bone edges were rounded. Muscle and fascia were harvested with the skin to provideadditional padding at the end of the stump. Postoperatively, the donkey was submitted to broad spectrum antibiotic, antiinflammatory and analgesic therapy, and tetanus prophylaxis. Preventative treatment for overload laminitis included frogsupport pads and resting leagues on all three legs. No short-term complications were observed and the donkey made a fullrecovery. Long-term complications included fistula formation on the stump, and distal interphalangeal joint...(AU)

Forelimb amputation and long-term follow-Up in a female donkey

Background: Limb amputation may be a life-saving procedure for animals and minimally impact their comfort and qualityof life, as previously reported in pets. This procedure is an appropriate alternative to euthanasia when catastrophic injury toa limb prevents its successful restoration. In horses, limb amputation has been performed for the past 40 years. Althoughin the reviewed literature there are no scientific reports of limb amputation in donkeys. This paper aimed to report a successful forelimb amputation and long-term follow-up in a female donkey.Case: A 10-month-old and 95 kg female Nordestino donkey was evaluated for a wound with bone exposition on the leftforelimb. Physical examination revealed that the donkey was alert with moderate body condition score, tachycardia, tachypnea, and a medial wound revealing the necrotic aspect of the left radius. Radiographic examination presented Salter-Harristype 1 exposed radius fracture. Hematology revealed normocytic and normochromic anemia, and hyperfibrinogenemia.Due to the catastrophic injury and no forecast for building a prosthesis, the donkey underwent general anesthesia for leftforelimb amputation through the midhumerus diaphysis. A fish-mouth skin incision was performed on the midhumerus,the underlying musculature was dissected and the vessels ligated until the bone could be accessed. Then, a sterile sawwire was used to transect it, and bone edges were rounded. Muscle and fascia were harvested with the skin to provideadditional padding at the end of the stump. Postoperatively, the donkey was submitted to broad spectrum antibiotic, antiinflammatory and analgesic therapy, and tetanus prophylaxis. Preventative treatment for overload laminitis included frogsupport pads and resting leagues on all three legs. No short-term complications were observed and the donkey made a fullrecovery. Long-term complications included fistula formation on the stump, and distal interphalangeal joint...

Paralytic rabies in a goat.

BACKGROUND: Paralytic form of rabies is frequent in cattle in Latin America, but it is uncommon in goats. There are few clinical reports on furious rabies affecting goats, and the sporadic cases of rabid goats from surveillance programs worldwide lack clinical data. Furthermore, few studies reported the cerebrospinal fluid findings in rabid livestock. CASE PRESENTATION: On a farm in Midwestern Brazil, six of 47 Saanen goats died within one week. No vaccination protocols were implemented on the farm and the owner stated bat bites history on the livestock. Although rabies is endemic in Brazil, livestock vaccination is not mandatory. One 1-year-old buck was evaluated and showed non-specific clinical signs evolving within 12-h to nervous signs. Cerebrospinal fluid analysis revealed mononuclear pleocytosis, hyperproteinemia and high glucose levels. At necropsy, no gross lesions were present. Microscopically, discrete to moderate perivascular lymphoplasmacytic cuffing in gray and white matter, neuronal necrosis, neuronophagia, and mononuclear ganglioneuritis was observed in the brainstem and cervical spinal cord. Immunohistochemistry revealed strong anti-rabies virus immunostaining. Fresh central nervous system samples were positive for rabies in direct fluorescent antibody test (dFAT) and mouse intracerebral inoculation test (MIT). Exposed livestock recommendations included immediate vaccination, a strict isolation period of 90 days, and booster vaccinations during the third and eighth weeks. CONCLUSION: IHC revealed the widespread distribution of rabies virus antigen in the goat's CNS, contrasting the discrete pathological changes. In this goat, definitive diagnosis of paralytic rabies was obtained through the association of epidemiological, clinical, laboratorial, pathological findings (histology and IHC) and gold standard confirmatory tests (dFAT and MIT).

Clinical-pathological and laboratorial findings in a horse with Schiff-Sherrington syndrome / Achados clínico-patológicos e laboratoriais em um equino com síndrome de Schiff-Sherrington

Background: Schiff-Sherrington syndrome is characterized by extensor hypertonicity of the forelimbs and flaccid hindlimbs as a result from the interruption of the ascending inhibitory effect on motor neurons of forelimbs. The main cause is trauma to the spinal cord in thoracolumbar segment and is considered a common condition in companion animals, but rarely reported in large animals. The present study aimed to report the clinical-pathological and laboratorial findings of a horse with Schiff-Sherington syndrome. Case: A 9-year-old mare weighing 330 kg was referred for clinical evaluation after a 36 h evolution of an acute onset of inability to stand. During physical examination the horse was on lateral recumbency and presented normal mental status, spasticity of the forelimbs, flaccid paralysis of the hind limbs, and superficial sensitivity decreased from the 13th thoracic vertebra, reaching the perianal region and hindlimbs. Hematological and biochemical abnormalities included mild neutrophilic leukocytosis, hypoalbuminemia and increased activity of aspartate aminotransferase. Cerebrospinal fluid (CSF) analysis showed yellowish coloration (xanthochromia), turbidity (+1), increased density, hypoproteinemia and erythrophagocytosis. Microbiological culture of CSF was negative. Necropsy revealed muscle hematomas and complete fracture of the 10th and 11th thoracic vertebrae with [...]

Clinical-pathological and laboratorial findings in a horse with Schiff-Sherrington syndrome / Achados clínico-patológicos e laboratoriais em um equino com síndrome de Schiff-Sherrington

Background: Schiff-Sherrington syndrome is characterized by extensor hypertonicity of the forelimbs and flaccid hindlimbs as a result from the interruption of the ascending inhibitory effect on motor neurons of forelimbs. The main cause is trauma to the spinal cord in thoracolumbar segment and is considered a common condition in companion animals, but rarely reported in large animals. The present study aimed to report the clinical-pathological and laboratorial findings of a horse with Schiff-Sherington syndrome. Case: A 9-year-old mare weighing 330 kg was referred for clinical evaluation after a 36 h evolution of an acute onset of inability to stand. During physical examination the horse was on lateral recumbency and presented normal mental status, spasticity of the forelimbs, flaccid paralysis of the hind limbs, and superficial sensitivity decreased from the 13th thoracic vertebra, reaching the perianal region and hindlimbs. Hematological and biochemical abnormalities included mild neutrophilic leukocytosis, hypoalbuminemia and increased activity of aspartate aminotransferase. Cerebrospinal fluid (CSF) analysis showed yellowish coloration (xanthochromia), turbidity (+1), increased density, hypoproteinemia and erythrophagocytosis. Microbiological culture of CSF was negative. Necropsy revealed muscle hematomas and complete fracture of the 10th and 11th thoracic vertebrae with [...](AU)