Verbal memory and executive components of recall in adolescent binge drinkers.

Introduction: Binge drinking (BD) is a common health-risk behavior among young people. Due to the incomplete maturation of the adolescent brain, BD can lead to structural and functional changes that impact neurocognitive processes, particularly executive functioning and verbal memory. This study aimed to investigate the influence of executive components, such as mnemonic strategies and error avoidance, on performance in a verbal memory test and the potential effects of BD on this performance. Methods: A sample of 160 college students (51.55% female) with a mean age of 18.12 ± 0.32 years completed assessments for alcohol use disorders using the Alcohol Use Disorder Identification Test (AUDIT), as well as psychopathological (Symptom Checklist-90-R) and neuropsychological evaluations (Verbal Learning Test Spain-Complutense and WMS-III Logical Memory). The Intensive Drinking Evaluation Instrument (IECI) was utilized to gather detailed information about binge drinking habits, including the calculation of the highest blood alcohol concentration (BAC) during an episode of intake. Results: Correlation and clustering analyses revealed a negative association between BAC values and verbal memory performance, as well as the use of memory strategies. The high BAC group (BD) exhibited negative values in verbal memory variables, higher accuracy errors, and less efficient strategy usage, while the low BAC group (No BD) demonstrated better memory test performance, fewer precision errors, and superior use of memory strategies. Discussion: These findings support the hypothesis that, when solving tests requiring verbal memory, adolescents reporting a BD consumption pattern show fewer executive skills in their resolution and, therefore, achieved poorer performance than non-binge drinkers. Addressing excessive alcohol consumption in young individuals is crucial for safeguarding their cognitive development and overall well-being.

Encapsulated eumycetoma caused by Biatriospora mackinnonii.

Eumycetoma is a chronic infection due to filamentous fungi. Herein, we report a case of eumycetoma presenting as a subcutaneous encapsulated lesion on the right leg with no previous traumatic implantation. From microscopic morphological characteristics and molecular analysis, the pathogenic fungal species were identified as Biatriospora mackinnonii. Surgical excision of the entire lesion was performed to reduce the fungal load and improve antifungal therapy response.

Reward sensitivity and hazardous alcohol consumption in women: The parallel mediation effect of self-control and impulsivity traits.

Introduction: Little research has been carried out on the associations between several individual factors and hazardous alcohol use in women. The aim of this study was first, to study the relationship between reward sensitivity (RS) and alcohol use in both women with and without hazardous drinking separately. Second, to explore the potential mediating roles of the impulsivity and self-control traits in this relationship. Method: The study was analytical and cross-sectional and included 645 female participants (mean age = 19.14; standard deviation (SD)=1.60). All women were divided into two groups (286, 44.3%, with hazardous drinking, HDW; and 359, 55.7%, with light drinking, LDW). Correlation analyses were carried out to explore the associations between the variables, and parallel mediation analyses were performed to investigate the potential mediating roles of impulsivity and self-control in the RS-alcohol use associations in each group separately. Results: A significant association was observed between RS and alcohol use in HDW, contrary to that observed in their counterparts. In addition, both higher impulsivity and less self-control mediated the association between RS and alcohol use only in HDW. Conclusions: Impulsivity and self-control differently affect alcohol use under the condition of high reward sensitivity, only in HDW, suggesting alterations of the dual top-down and bottom-up mechanisms and a possible imbalance between the competing reflexive and impulsive brain systems. More research is needed regarding the individual factors that affect women's drinking to develop sensitive measures for the assessment of alcohol use and more efficient interventions for women.

Electrophysiological resting-state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking.

Adolescent Binge Drinking (BD) has become an increasing health and social concern, with detrimental consequences for brain development and functional integrity. However, research on neurophysiological and neuropsychological traits predisposing to BD are limited at this time. In this work, we conducted a 2-year longitudinal magnetoencephalography (MEG) study over a cohort of initially alcohol-naïve adolescents with the purpose of exploring anomalies in resting-state electrophysiological networks, impulsivity, sensation-seeking, and dysexecutive behaviour able to predict future BD patterns. In a sample of 67 alcohol-naïve adolescents (age = 14.5 ± 0.9), we measured resting-state activity using MEG. Additionally, we evaluated their neuropsychological traits using self-report ecological scales (BIS-11, SSS-V, BDEFS, BRIEF-SR and DEX). In a second evaluation, 2 years later, we measured participant's alcohol consumption, sub-dividing the original sample in two groups: future binge drinkers (22 individuals, age 14.6 ± 0.8; eight females) and future light/no drinkers (17 individuals, age 14.5 ± 0.8; eight females). Then, we searched for differences predating alcohol BD intake. We found abnormalities in MEG resting state, in a form of gamma band hyperconnectivity, in those adolescents who transitioned into BD years later. Furthermore, they showed higher impulsivity, dysexecutive behaviours and sensation seeking, positively correlated with functional connectivity (FC). Sensation seeking and impulsivity mainly predicted BD severity in the future, while the relationship between dysexecutive trait and FC with future BD was mediated by sensation seeking. These findings shed light to electrophysiological and neuropsychological traits of vulnerability towards alcohol consumption. We hypothesise that these differences may rely on divergent neurobiological development of inhibitory neurotransmission pathways and executive prefrontal circuits.

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism.

Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms underlying the resistance of metastatic lesions to WBRT, we sought to uncover actionable targets and biomarkers that could help to refine patient selection. Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-κB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically or pharmacologically was sufficient to revert the WBRT resistance and increase therapeutic benefits in vivo at lower doses of radiation. In patients with primary melanoma, lung or breast adenocarcinoma developing brain metastasis, endogenous S100A9 levels in brain lesions correlated with clinical response to WBRT and underscored the potential of S100A9 levels in the blood as a noninvasive biomarker. Collectively, we provide a molecular framework to personalize WBRT and improve its efficacy through combination with a radiosensitizer that balances therapeutic benefit and toxicity.

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.

We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood-brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere.

Clinical improvement after cranioplasty and its relation to body position and cerebral hemodynamics.

Cranioplasty after decompressive craniectomy (DC) has been found to improve the neurological condition. The underlying mechanisms are still unknown. The aim of this study is to investigate the roles of the postural changes and atmospheric pressure (AP) in the brain hemodynamics and their relationship with clinical improvement. Seventy-eight patients were studied before and 72 h after cranioplasty with cervical and transcranial color Doppler ultrasound (TCCS) in the sitting and supine positions. Craniectomy size, shape, and force exerted by the AP (torque) were calculated. Neurological condition was assessed with the National Institutes of Health Stroke Scale (NIHSS) and the Barthel index. Twenty-eight patients improved after cranioplasty. Their time elapsed from the DC was shorter (214 vs 324 days), preoperative Barthel was worse (54 vs 77), internal carotid artery (ICA) mean velocity of the defect side was lower while sitting (14.4 vs 20.9 cm/s), and torque over the craniectomy was greater (2480.3 vs 1464.3 N*cm). Multivariate binary logistic regression showed the consistency of these changes. TCCS findings were no longer present postoperatively. Lower ICA (defect side) velocity in the sitting position correlates significantly with clinical improvement. Greater torque exerted by the AP might explain different susceptibilities to postural changes, corrected by cranioplasty.

Snorting the Brain Away: Cerebral Damage as an Extension of Cocaine-Induced Midline Destructive Lesions.

Cocaine consumption is associated with a variety of clinical manifestations. Though cocaine intranasal inhalation always determines nasal mucosal damages, extensive septum perforations, and midline destructions-known as cocaine-induced midline destructive lesions (CIMDL)-affect only a limited fraction of patients. CIMDL is viewed as a cocaine-associated autoimmune phenomenon in which the presence of atypical anti-neutrophil cytoplasmic antibody (ANCA) promotes and/or defines the disease phenotype. A 51-year-old man presented with an intracranial tumor-like lesion by its space-occupying effect. CT also revealed the destruction of the nasal septum and skull base. A diagnosis of CIMDL was made in light of the patient's history as well as findings of the physical and endoscopic examinations, imaging studies, and laboratory testing. There was no evidence of other pathologies. Histopathological results from cerebral biopsy led us to consider the intracranial pathology as an extension of the CIMDL. CIMDL is the result of a necrotizing inflammatory tissue response triggered by cocaine abuse in a subset of predisposed patients. The reported case is the first CIMDL consistent with brain extension mimicking a tumor-like lesion. While the presence of atypical ANCA seems to promote and/or define the disease phenotype, the specific role of these and other circulating autoantibodies needs further investigation.

Reduction in the infection rate of cranioplasty with a tailored antibiotic prophylaxis: a nonrandomized study.

BACKGROUND: Cranioplasty carries a high risk of surgical site infections (SSIs) for a scheduled procedure, particularly with antibiotic-resistant bacteria. METHODS: The goal of this retrospective study was to measure the effect of tailored antibiotic prophylaxis on SSIs resulting from cranioplasties. The authors collected a prospective database of cranioplasties from 2009 to 2018. Risk factors for SSI were registered, as well as infection occurring during the first year postoperatively. A new protocol was initiated in 2016 consisting of antibiotic prophylaxis tailored to the colonizing flora of the skin of the scalp and decolonization of patients who were nasal carriers of methicillin-resistant S. aureus (MRSA); infection rates were compared. RESULTS: One hundred nine cranioplasties were identified, 64 in the old protocol and 45 in the new protocol. Of the 109 cranioplasties, 16 (14.7%) suffered an infection, 14 (21.9%) in the old protocol group and 2 (4.4%) in the new protocol group (OR for the new protocol 0.166, 95% CI 0.036-0.772). Multiple surgeries (OR 3.44), Barthel ≤ 70 (OR 3.53), and previous infection (OR 3.9) were risk factors for SSI. Of the bacteria identified in the skin of the scalp, 22.2% were resistant to routine prophylaxis (cefazoline). Only one patient was identified as a nasal carrier of MRSA and was decolonized. CONCLUSIONS: A high percentage of bacteria resistant to routine prophylaxis (cefazoline) was identified in the skin of these patients' scalps. The use of tailored antibiotic prophylaxis reduced significantly the infection rate in this particular set of patients.

Delayed extensive brain edema caused by the growth of a giant basilar apex aneurysm treated with basilar artery obliteration: a case report.

BACKGROUND: Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a surgically treated and thrombosed giant basilar apex aneurysm. CASE PRESENTATION: We performed a proximal surgical basilar artery occlusion on a 64-year-old female with a partially thrombosed giant BA aneurysm. MRI showed no ischemic lesions but showed marked edema adjacent to the aneurysm. She had a good recovery, but 3 months after surgical occlusion, her gait deteriorated together with urinary incontinence and worsening right hemiparesis. MRI showed that the aneurysm had grown and developed intramural hemorrhage, which caused extensive brain edema and obstructive hydrocephalus. She was treated by a ventriculoperitoneal shunt placement. Follow-up MRI showed progressive brain edema resolution, complete thrombosis of the lumen and shrinkage of the aneurysm. At 5 years follow-up the patient had an excellent functional outcome. CONCLUSIONS: Delayed growth of a surgically treated and thrombosed giant aneurysm from wall dissection demonstrates that discontinuity with the initial parent artery does not always prevent progressive enlargement. The development of transmural vascular connections between the intraluminal thrombus and adventitial neovascularization by the vasa vasorum on the apex of the BA seems to be a key event in delayed aneurysm growth. Extensive brain edema might translate an inflammatory edematous reaction to an abrupt enlargement of the aneurysm.

Young alcohol binge drinkers have elevated blood endotoxin, peripheral inflammation and low cortisol levels: neuropsychological correlations in women.

Alcohol binge drinking is a pattern of heavy alcohol consumption that is increasingly practiced by adolescents and young adults. Evidence indicates that alcohol binges induce peripheral inflammation and an exacerbated neuroimmune response that may participate in alcohol-induced cognitive/behavioral dysfunctions. Here, we recruited 20-year-old male and female university students who were identified as binge drinkers for at least 2 years. Compared with controls, young alcohol binge drinkers had elevated levels of blood endotoxin and upregulated markers of the toll-like receptor 4/NF-κB inflammatory pathway in peripheral blood mononuclear cells, together with pro-inflammatory cytokine/chemokine release, oxidative stress and lipid peroxidation. These changes positively correlate with the estimated blood alcohol levels achieved during alcohol binge intoxication and negatively correlate with the time elapsed from the last alcohol consumption. The immune/inflammatory changes were more prominent in female drinkers, who showed elevated levels of alcohol danger-associated molecules, such as high mobility group box 1, indicating that there are sex-related differences in the peripheral inflammatory response to alcohol. In contrast, cortisol levels were decreased in alcohol binge drinkers. Finally, higher levels of inflammatory markers, mainly monocyte chemoattractant protein-1, as well as LPS, high mobility group box 1, toll-like receptor 4, IL-6 and ciclooxygenase-2, correlated with worse scores on episodic memory and executive functioning tasks in female binge drinkers but not in male binge drinkers. These results emphasize possible risky consequences of alcohol use in binge episodes during young adulthood and call attention to sex-related differences in the alcohol-induced immune/inflammatory and neurocognitive responses.

Almeria spatial memory recognition test (ASMRT): Gender differences emerged in a new passive spatial task.

Many different human spatial memory tasks were developed in the last two decades. Virtual reality based tasks make possible developing different scenarios and situations to assess spatial orientation but sometimes these tasks are complex for specific populations like children and older-adults. A new spatial task with a very limited technological requirement was developed in this study. It demanded the use of spatial memory for an accurate solution. It also proved to be sensitive to gender differences, with men outperforming women under high specific difficulty levels. Thanks to its simplicity it could be applied as a screening test and is easy to combine with EEG and fMRI studies.

The treatment of madness in the nineteenth and twentieth centuries: discourses about curability in Spanish mental health care, 1890-1917. / El tratamiento de la locura entre los siglos XIX y XX: los discursos sobre la cura en la medicina mental española, 1890-1917.

This article studies the discourses about curability constructed by Spanish mental health practitioners in the transition from the nineteenth to the twentieth century. While in the 1870s and 1880s the predominant discourse promoted by doctors attached to private institutions was extremely optimistic, it subsequently changed and became more pessimistic regarding treatment outcomes. However, given phrenopathists' professional needs, they continued to profess more or less unshakeable confidence in the therapeutic abilities of psychiatry. The reception of new nosologies, such as Kraepelin's, depended in part on contemporary mental health practitioners' stance on curability and was accompanied by ambivalence.

El tratamiento de la locura entre los siglos XIX y XX: los discursos sobre la cura en la medicina mental española, 1890-1917 / The treatment of madness in the nineteenth and twentieth centuries: discourses about curability in Spanish mental health care, 1890-1917

Resumen En el trabajo se estudian los discursos sobre la cura que elaboraron los médicos mentalistas españoles en la transición del siglo XIX al XX. Si en las décadas de los años 1870 y 1880 el discurso preponderante promulgado por los médicos pertenecientes a instituciones privadas era extremadamente optimista, posteriormente cambió y se orientó hacia un mayor pesimismo terapéutico. Sin embargo, dadas las necesidades profesionales de los frenópatas, siguieron mostrando una confianza más o menos firme hacia las capacidades terapéuticas de la psiquiatría. La recepción de las nuevas nosologías, como la de Kraepelin, estuvo condicionada, en parte, por la actitud hacia la cura de los médicos mentalistas de la época y fue aceptada de forma ambivalente.

Abstract This article studies the discourses about curability constructed by Spanish mental health practitioners in the transition from the nineteenth to the twentieth century. While in the 1870s and 1880s the predominant discourse promoted by doctors attached to private institutions was extremely optimistic, it subsequently changed and became more pessimistic regarding treatment outcomes. However, given phrenopathists’ professional needs, they continued to profess more or less unshakeable confidence in the therapeutic abilities of psychiatry. The reception of new nosologies, such as Kraepelin’s, depended in part on contemporary mental health practitioners’ stance on curability and was accompanied by ambivalence.

Early alcohol use and psychopathological symptoms in university students / Consumo temprano de alcohol y síntomas psicopatológicos en estudiantes universitarios

BACKGROUND: Adolescent brain may be particularly vulnerable to alcohol. Plus, psychopathological disorders tend to emerge in this period. Consequently, early alcohol use may increase the risk of psychopathological disorders, with time and sex-dependent effects. However, few studies have analyzed the relationship between alcohol consumption and adolescent psychopathology in the general population. The objective was to determine the association between age of onset of alcohol use and psychopathological symptoms in university students, separately for both sexes. METHOD: A cross-sectional study involving fi rst-year university students (n = 3,696) was conducted. Symptoms were measured by the Symptom Checklist-R (SCL-90-R). The independent variable was age of fi rst alcohol use. Dependent variables were the SCL-90-R dimensions, dichotomized. Alcohol consumption was considered a mediator variable. Data were analyzed separately for males and females. RESULTS: The fi ndings showed that a younger age of onset is a risk factor for the following global indexes: Global Severity Index, Positive Symptom Total for females, and Positive Symptom Distress Index, for males. Alcohol consumption showed a higher mediator effect for females than for males. CONCLUSION: Early age of alcohol use is associated with increased psychopathological symptomatology in both sexes during the college freshman year. The pattern of symptomatology is different in each sex

ANTECEDENTES: durante la adolescencia el cerebro es especialmente vulnerable a los efectos del alcohol. El consumo temprano de alcohol puede aumentar el riesgo de sintomatología psicopatológica. Pocos estudios han analizado la relación entre consumo de alcohol y sintomatología psicopatológica en adolescentes en la población general. El objetivo de este estudio es determinar la asociación entre edad de inicio del consumo de alcohol y síntomas psicopatológicos en estudiantes universitarios, separadamente para ambos sexos. MÉTODO: estudio transversal en estudiantes universitarios (n = 3.696). Los síntomas se midieron con el SCL-90-R. La variable independiente fue la edad de inicio del consumo de alcohol. Las variables dependientes fueron las dimensiones del SCL-90-R dicotomizadas. El consumo de alcohol fue una variable mediadora. RESULTADOS: una temprana edad de inicio es un factor de riesgo para los siguientes índices globales: Índice de Severidad Global, Total de Síntomas Positivos, solo en mujeres, e Índice de Malestar, solo para hombres. El consumo de alcohol muestra un mayor efecto mediador en las mujeres. CONCLUSIÓN: una temprana edad de inicio en el consumo de alcohol se asocia con un aumento de sintomatología psicopatológica en ambos sexos durante el primer año de Universidad. El patrón de sintomatología difi ere en hombres y mujeres

Weekend alcoholism in youth and neurocognitive aging / Alcoholismo de fin de semana en jóvenes y envejecimiento neurocognitivo

Numerous studies have shown that alcohol intake causes neuropsychological disorders that affect various brain structures. The «premature ageing» hypothesis proposes that the brain areas of alcoholics undergo deterioration similar to that observed in old age. We investigated whether alcohol abuse by young people (binge drinking) causes alterations comparable to some found in elderly people. Ninetyone people were divided into four groups: a) young people who abused alcohol; b) young people who drank alcohol in moderation; c) young people who did not drink alcohol; and d) elderly adults without any significant cognitive deterioration. All of them were assessed with a neuropsychological battery. We observed some similarities in the results obtained by young drinkers and the elderly participants, which would provide some support for the hypothesis of premature aging. The tasks that young drinkers performed worse were those related to executive functions, in which the prefrontal cortex plays an essential role. We also found differences between the two groups of young drinkers (moderate and high consumption), which leads us to believe that the amount of alcohol consumed and the pattern of consumption are factors to consider in relation to cognitive impairment (AU)

Numerosos estudios han demostrado que la ingesta de alcohol provoca alteraciones neuropsicológicas que afectan a diferentes estructuras en el cerebro. La hipótesis del «envejecimiento prematuro» propone que las áreas del cerebro de alcohólicos sufren un deterioro similar al observado en la vejez. Hemos investigado si el consumo abusivo de alcohol en jóvenes ocasiona algunas alteraciones comparables a las encontradas en personas de edad avanzada. Noventa y una personas fueron divididas en cuatro grupos: a) jóvenes que abusaban del alcohol; b) jóvenes que bebían con moderación; c) jóvenes que no bebían alcohol; y d) ancianos sin deterioro cognitivo significativo, y evaluados con una batería neuropsicológica. Observamos ciertas similitudes entre los resultados obtenidos por los jóvenes bebedores y los mayores, en línea con la hipótesis del envejecimiento prematuro. Las tareas que los jóvenes bebedores realizaron peor fueron las relacionadas con funciones ejecutivas, donde la corteza prefrontal juega un papel esencial. También encontramos diferencias entre los dos grupos de jóvenes bebedores (consumo alto y moderado), lo que nos lleva a pensar que la cantidad de alcohol ingerido y el patrón de consumo son factores a tener en cuenta en relación con el deterioro cognitivo (AU)

[Prefrontal activity and weekend alcoholism in the young]. / Actividad prefrontal y alcoholismo de fin de semana en jovenes.

BACKGROUND: High alcohol consumption by young people at weekends is a public health problem of considerable social and family importance. Chronic alcohol intake causes structural changes in the central nervous system, though the effects are not uniform throughout the brain. The prefrontal cortex (PC) has been reported to be one of the regions most sensitive to prolonged alcohol ingestion. OBJECTIVES: The effects of chronic ethanol exposure have been extensively studied. Our aim is to identify the neuropsychological deficits in PC function induced by intermittent heavy alcohol drinking in young adults. METHODS: Neuropsychological assessment was carried out on participants to examine their performance in PC-dependent tasks. 62 subjects (mean age 18.82+/-1.099) were assigned to one of three categories: 1) Those reporting heavy binge drinking of alcohol at weekends (ALE); 2) Those reporting moderate binge drinking of alcohol at weekends (ALM); and 3) Those reporting no alcohol intake (CTR). RESULTS AND CONCLUSIONS: The findings indicate that intermittent alcohol binge drinking, either heavy or moderate, in young people results in poorer performance in neuropsychological tasks such as Digits, Corsi or Stroop, which depend on correct PC functioning. Our results support the claim that the binge pattern of exposure to ethanol leads to neurocognitive and neurobehavioural impairment equivalent, in many respects, to that found in chronic drinkers. Moreover, intermittent heavy alcohol drinking in adolescence and early adulthood increases the risks of lifetime alcohol dependence and other psychopathologies.

Actividad prefrontal y alcoholismo de fin de semana en jóvenes / Prefrontal activity and weekend alcoholism in young

Antecedentes. El consumo elevado de alcohol por parte de jóvenes durante el fin de semana se está convirtiendo en un problema social y familiar importante pero también en un problema de salud considerable. El consumo abusivo ocasiona daños en el cerebro pero con diferente distribución, ya que la corteza prefrontal (CP) es una de las regiones que resulta más afectada. Objetivos. Hay numerosos estudios sobre los efectos del consumo crónico de alcohol. Nuestro objetivo es determinarlos déficits neuropsicológicos en la actividad prefrontal ocasionados por el consumo abusivo de alcohol de manera intermitente en adolescentes. Método. Se realizó una evaluación neuropsicológica a los sujetos para valorar su rendimiento en diversas tareas que implican a la CP. Participaron 62 sujetos (edad media 18.82±1.099) distribuidos en tres grupos: 1) Jóvenes que consumían alcohol de manera abusiva durante los fines de semana (ALE); 2) Jóvenes que consumían más moderadamente durante los fines de semana (ALM); y 3) Jóvenes que no consumían alcohol (CTR). Resultados y Conclusiones. Los resultados indican que el consumo abusivo intermitente de alcohol por parte de jóvenes, tanto de manera elevada como moderada, provoca un peor rendimiento en tareas neuropsicológicas como Dígitos, Corsi o Stroop, las cuales dependen de un correcto funcionamiento de la CP. Nuestros resultados apoyan la idea de que este patrón de consumo provoca un deterioro neurocognitivo y neuroconductual similar en muchos aspectos al observado en bebedores crónicos. Además, el consumo abusivo de fin de semana por parte de adolescentes y jóvenes incrementa el riesgo de desarrollar dependencia alcohólica y otras patologías en etapas posteriores de la vida

Background. High alcohol consumption by young people at weekends is a public health problem of considerable social and family importance. Chronic alcohol intake causes structural changes in the central nervous system, though the effects are not uniform throughout the brain. The prefrontal cortex (PC) has been reported to be one of the regions most sensitive to prolonged alcohol ingestion. Objectives. The effects of chronic ethanol exposure have been extensively studied. Our aim is to identify the neuropsychological deficits in PC function induced by intermittent heavy alcohol drinking in young adults. Methods. Neuropsychological assessment was carried out on participants to examine their performance in PC-dependent tasks. 62 subjects (mean age 18.82±1.099) were assigned toone of three categories: 1) Those reporting heavy binge drinking of alcohol at weekends (ALE); 2) Those reporting moderate binge drinking of alcohol at weekends (ALM); and 3) Those reporting no alcohol intake (CTR). Results and Conclusions. The findings indicate that intermittent alcohol binge dr inking, either heavy or moderate, in young people results in poorer performance in neuropsychological tasks such as Digits, Corsi or Stroop, which depend on correct PC functioning. Our results support the claim that the binge pattern of exposure to ethanol leads to neurocognitive and neurobehavioural impairment equivalent, in many respects, to that found inchronic drinkers. Moreover, intermittent heavy alcohol drinking in adolescence and early adulthood increases the risks of lifetime alcohol dependence and other psychopathologies