Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid.

This paper presents results of the radiological study and DTPA therapy for a worker exposed to a plutonium nitrate solution. Plutonium levels were measured in excreta, blood, plasma and wound for several weeks. Plutonium renal clearance ranged from 110-190 ml min(-1) to 3-4 ml min(-1) at different stages of chelation therapy. Plutonium absorption into blood from the injured skin amounted to 4.3%. As a result of intensive therapy, 96% of absorbed plutonium was successfully excreted.

[The effect of the components of general anesthesia on the level of carcinoembryonic antigen in the blood serum of patients with cancer of the large intestine]. / Vliianie komponentov obshchei anestezii na uroven rakovo-émbrionalnogo antigena v syvorotke krovi bolnykh rakom tolstoi kishki.

The effect of calipsol and thiopental (the most frequent drugs used for basis anesthesia), as well as their combinations with narcotic analgesics fentanyl, morphine, promedole and a neuroleptic droperidol on the level of carcinoembryonic antigen (CEA) in patients with colonic cancer has been studied. A significant effect of anesthetics on CEA level in the postoperative period has been established. The lowest CEA level was observed when calipsol, morphine, and promedole were used as components of narcotic analgesics.

[The diagnostic value of determining the level of the carbohydrate antigen 19-9 in pancreatic cancer]. / Diagnosticheskaia tsennost' opredeleniia urovnia karbogidratnogo antigena 19--9 pri rake podzheludochnoi zhelezy.

By means of a radioimmunologic method, the serum level of carbohydrate antigen (CA) 19-9 was measured in 96 patients, including 17 with pancreatic cancer, 35--with inflammatory diseases of the pancreas, 44--with cancer of another location. CA 19-9 level in patients with pancreatic cancer was considerably higher than in patients with other diseases and controls.

[Tumor markers--a diagnostic and prognostic test]. / Opukholevye markery--diagnosticheskii i prognosticheskii test.

Blood levels of carcinoembryonic antigen (CEA), alpha-fetoprotein, ferritin, ACTH. triiodothyronine and thyroxin were measured by radioimmunoassay in 217 cases of lung, hepatopancreatoduodenal and colonic cancer, 61 patients with nontumor pathology of those sites and in 37 healthy controls. CEA proved the most reliable marker of lung and colonic cancer and tumor-related mechanical jaundice, its lowest concentration in 65-100% of cancer patients exceeding the highest levels observed in controls. In the colorectal group, CEA level returned to normal after radical surgery and rose again at recurrence or distant metastases. Ferritin, cortisol and ACTH appeared less efficient.

[Determination of carcinoembryonic antigen content as a diagnostic and prognostic test in colorectal cancer]. / Opredelenie soderzhaniia rakovoémbrional'nogo antigena kak diagnosticheskii i prognosticheskii test pri kolorektal'nom rake.

Of the 120 patients with colorectal cancer, 24 had distant metastases of a tumor. In these patients, increase in the level of carcinoembryonic antigen (CEA) and ferritin in the peripheral blood serum was noted as compared with those in patients without tumor metastases (P less than 0.001). Measuring of CEA content in the peripheral and regional blood can be used in preoperative diagnosis of metastases of colorectal cancer.

[Importance of carcinoembryonic antigen, alpha-fetoprotein and cholylglycine in differential diagnosis of viral hepatitis B and mechanical jaundice]. / Znachenie rakovo-émbrional'nogo antigena, alpha-fetoproteina i kholilglitsina v diferentsial'noi diagnostike virusnogo gepatita B i mekhanicheskoi zheltukhi.

Fifty-four patients with viral hepatitis B (VHB) were examined at the height of the disease as were 30 patients with mechanical jaundice (MJ) of tumorous etiology and 19 normal persons. Mechanical jaundice was mainly characterized by a considerable growth of the concentration of carcinoembryonic antigen, whereas VHB by an increase of the cholylglycine level. Concomitant detection of those markers can be used in differential diagnosis of parenchymatous jaundice and mechanical jaundice of tumorous etiology. Alterations of the alpha-fetoprotein level were of no information content.

[Radioimmunological analysis of gonadotropic and steroid hormones in breast cancer]. / Radioimmunologicheskii analiz gonadotropnykh i steroidnykh gormonov pri rake molochnoi zhelezy.

A study of the blood levels of gonadotropic and steroid hormones in 321 breast cancer patients has shown that the basal levels of gonadotropin concentration in them exceed the control values (p less than 0.05); those of the follicle-stimulating hormone--in 54.1% of patients at reproductive age and in menopause less than 5 years and in 33.8% of patients in menopause over 5 years; those of luteotropin--in 50 and 93.5% of patients, respectively. Low basal levels of estradiol and progesterone were found more than 70% of breast cancer patients. A significant decrease in the level of the above hormones (p less than 0.05) was noted after polychemotherapy. An increase in the levels of corticotropin (in 54.5-65.2% of patients) and cortisol (in 81.6-84.3% of patients) was noted with progression of breast cancer. Data on the above hormones can be used as a diagnostic and prognostic test.

[Large-field irradiation of patients with a disseminated tumor process]. / Krupnopol'noe obluchenie bol'nykh s disseminirovannym opukholevym protsessom.

Large field fractionated irradiation was provided to 32 patients aged 24 to 75 with tumor dissemination in the absence of the effect of other types of therapy including local gamma-beam therapy. The upper part of the body (as a result of the lung involvement) was irradiated in most of the patients. A single dose of irradiation was 100-500 cGy, the total dose--10-24 Gy. Irradiation was delivered from 2 opposite fields using a ROKUS-M unit. The effect was noted in 5 patients, improvement of the general status--in 22, remission--in 5 patients, 16 patients died. Their mean survival time starting from large field irradiation was 6.5 mos (1-10 mos).

[Use of non-traditional methods of examination in the differential diagnosis of cancer and tuberculosis of the lungs]. / Ispo'lzovanie netraditsionnykh metodov issledovaniia v diffe- rentsia'lnoi diagnostike raka i tuberkuleza legkikh.

The immunoradiometric assay of the blood serum was performed in 61 patient with cancer and in 57 patients with tuberculosis of the lungs to determine the content of adrenocorticotropic hormone (ACTH), hydrocortisone, triiodothyronine++ (T3), thyroxin (T4), ferritin and carcinoembryonic antigen (CEA). In 200 patients (104 suffered from pulmonary tuberculosis, 9--pulmonary cancer), entropy of the protein fractions of the blood serum was determined. It was established that in differential diagnosis of pulmonary cancer and tuberculosis, the determination of CEA, hydrocortisone and entropy of the protein fractions of the blood serum in the complex with the other methods were of significant importance, the determination of ACTH and ferritin content were less important.