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1.
Artículo en Ruso | MEDLINE | ID: mdl-22308721

RESUMEN

AIM: Development a method of treatment of Streptococcus pyogenes bacteria that does not disrupt the integrity of surface structure of cell and provides optimal reproducibility of enzyme preparation activity test results. MATERIALS AND METHODS: Museum cultures of S. pyogenes M29 and S. pyogenes T1 were used, as well as standard strain S.pyogenes T5 (ATCC) and 3 phage-associated lysine PlyC preparations (enzybiotics): 2 isolated from phage C1, third--recombinant enzyme obtained by cloning phage C1 DNA. 3 methods of S. pyogenes cells treatment were used: inactivation by chloroform, antibiotics and heating. RESULTS: Treatment of S. pyogenes cells by rifampicin and gentamicin allows simultaneous turbidimetric determination of enzyme preparations activity and streptococci lysis effectiveness with a good reproducibility of test results. Comparison of kinetic curves of streptococci lysis killed by heating with curves of live culture lysis showed that heat treatment of cells results in a decrease oflysis depth and a reduction of enzyme activity. Pattern and effectiveness of lysis of cells incubated with chloroform approached curve of live streptococci lysis, however this method did not exclude lysis of part of cells and required presence of equipment for work with chemical substances. CONCLUSION. S. pyogenes test culture inactivation method by 2-step treatment of culture with antibiotics that does not disrupt the integrity of surface structure of cells and provides optimal reproducibility of enzyme preparation activity test results was developed.


Asunto(s)
Antibacterianos/farmacología , Bacteriólisis/efectos de los fármacos , Nefelometría y Turbidimetría/métodos , Fagos de Streptococcus/enzimología , Streptococcus pyogenes/enzimología , Cloroformo , Gentamicinas/farmacología , Calor , Cinética , Reproducibilidad de los Resultados , Rifampin/farmacología , Fagos de Streptococcus/genética , Streptococcus pyogenes/química , Streptococcus pyogenes/efectos de los fármacos , Streptococcus pyogenes/crecimiento & desarrollo , Streptococcus pyogenes/aislamiento & purificación
2.
Ter Arkh ; 77(3): 60-4, 2005.
Artículo en Ruso | MEDLINE | ID: mdl-15881102

RESUMEN

AIM: To evaluate effects of fozinopril on basic manifestations of metabolic syndrome in women with moderate and severe arterial hypertension (AH). Material and methods. Sixty women with AH aged 45 to 65 years entered the trial. Mean duration of the disease was 11 years. Arterial pressure (AP), carbohydrate, lipid and purin metabolism, lipid peroxidation, erythrocytic membranes resistance were examined before the trial and followed up for 6 months of the treatment. RESULTS: Fozinopril significantly reduced systolic and diastolic AP. A 6-month course of the drug brought target AP in 85.4% examinees, a good response was achieved in 96.4%. The treatment also significantly reduced the levels of insulin, C-peptide, triglycerides, increased content of HDLP cholesterol, relieved insulin resistance. Fozinopril demonstrated antioxidant, membrane stabilizing and hypouricemic efficacy. CONCLUSION: High antihypertensive efficacy and a positive action on basic manifestations of metabolic disorders allow us to recommend fozinopril as a basic drug for treatment of women with moderate and severe AH concurrent to insulin resistance syndrome.


Asunto(s)
Antihipertensivos/uso terapéutico , Fosinopril/uso terapéutico , Hipertensión/tratamiento farmacológico , Síndrome Metabólico/tratamiento farmacológico , Anciano , Antihipertensivos/farmacología , Presión Sanguínea/efectos de los fármacos , Femenino , Fosinopril/farmacología , Humanos , Hipertensión/etiología , Síndrome Metabólico/complicaciones , Persona de Mediana Edad
3.
4.
Artículo en Ruso | MEDLINE | ID: mdl-629134

RESUMEN

The report contains some results of a 3 year study of combined intensive psychopharmacological and occupational therapy of 120 patients (on the basis of the Gannushkin City Mental Hospital N4 and 2 industrial plants) during the stage of a subacute development of the schizophrenic process. On the basis of clinical and methodological criteria the authors distinguish 3 groups of patients and 3 types of rehabilitative programmes respectively. The medical and socio-occupational effectiveness of the new modification of combined intensive psychopharmacological industrial therapy of schizophrenic patients has been confirmed.


Asunto(s)
Terapia Ocupacional , Psicotrópicos/uso terapéutico , Esquizofrenia/terapia , Antidepresivos/uso terapéutico , Enfermedad Crónica , Industria de Procesamiento de Alimentos , Humanos , Moscú , Trastornos de la Personalidad/terapia , Remisión Espontánea , Esquizofrenia/rehabilitación
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