RESUMEN
Investigations using immunofluorescence and immunoperoxidase techniques revealed a gradual, but marked, increase in the numbers of immunoglobulin-secreting cells in the skin of pigs during the development of lesions of sarcoptic mange. This was followed by a marked decrease as the lesions regressed. The rise and fall in numbers of these immunoglobulin-secreting cells were observed in both newborn and older animals as they developed signs of cutaneous disease. IgG-secreting cells were the major immunoglobulin-containing cells, followed by IgM- and then IgA-containing cells in the skin of newborn animals. In older pigs, IgM-secreting cells were most prevalent, followed by IgG- and IgA-secreting cells. In multiple infestations, immunoglobulin-secreting cells in the dermis showed very little increase in numbers following the second infestation. Third, fourth and fifth infestations produced little or no increase.
Asunto(s)
Células Productoras de Anticuerpos/inmunología , Inmunoglobulinas/biosíntesis , Escabiosis/veterinaria , Piel/inmunología , Enfermedades de los Porcinos/inmunología , Animales , Animales Recién Nacidos , Células Productoras de Anticuerpos/patología , División Celular , Femenino , Técnica del Anticuerpo Fluorescente , Técnicas para Inmunoenzimas , Inmunoglobulina A/biosíntesis , Inmunoglobulina G/biosíntesis , Inmunoglobulina M/biosíntesis , Masculino , Escabiosis/inmunología , Piel/patología , Organismos Libres de Patógenos Específicos , PorcinosRESUMEN
Scanning electron microscopy revealed that lesions of sarcoptic mange in swine, pass through 3 different stages. During the first 3 weeks of infestation, adult female mites tunnel into the epidermis. During the following 3 or 4 weeks, the surface openings of these tunnels become covered with keratinized epidermal crust which increases in thickness. After 7 weeks of infestation, the crust falls off, the tunnel openings become apparent again and most of the mites vacate these tunnels.