1.
J Org Chem
; 85(14): 9015-9028, 2020 07 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32508100
RESUMEN
An efficient cascade approach to thiosubstituted benzoxazoles has been developed. The transformation starts with in situ generation of a diazo compound via annulation-triggered electrocyclic opening of the 1,2,3-triazole ring. The subsequent Cu-catalyzed trapping of diazo intermediates by various thiols affords the desired heterocycles in generally good yields of up to 91%. The protocol features very good functional group tolerance and is applicable to substrates with different electronic properties.