RESUMEN
BACKGROUND: A number of studies have indicated a link between gastrointestinal (GI) diseases and autism spectrum disorders. METHOD: The objective of this study was to compare the prevalence and types of GI diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with GI diseases in 336 matched controls from the general population, based on data from the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3 years (SD 0.4) (range 27-30 years), and mean age at the end of the observation period was 42.7 years (SD 7.7) (range between 27 and 57 years of age). RESULTS: Of the 118 individuals with IA, 97 (82.2%) had been in contact with a medical hospital (inpatient hospitalization or outpatient visits) during the observation period, compared with 312/336 (92.9%) in the control group (P= 0.001). A similar proportion of members from the case and comparison group had a diagnosis of any GI disease in the DNHR: 30.5% against 30.7%, but the nature of their diseases may be somewhat different. Only diseases of oral cavity were significantly associated with IA: 20.3% against 1.2%, P < 0.0001. Otherwise, specific GI diseases occurred with low frequency in both groups. CONCLUSION: Overall, no evidence was found that patients with IA were more likely than control persons without IA to have defined GI diseases during the 30.3-year observation period.
Asunto(s)
Trastorno Autístico/epidemiología , Enfermedades Gastrointestinales/epidemiología , Adolescente , Niño , Preescolar , Dinamarca/epidemiología , Métodos Epidemiológicos , Femenino , Humanos , Pruebas de Inteligencia , MasculinoRESUMEN
BACKGROUND: A number of studies have shown that the diagnosis of developmental language disorder (DLD) can be unstable over time, such that young children with a diagnosis of DLD may show symptoms more characteristics of autism spectrum disorder (ASD) at a later date. METHOD: To estimate the types and prevalence of ASD 469 individuals with a DLD, consecutively assessed in the same clinic during a period of 10 years, and 2345 controls from the general population were screened for ASD through the nationwide Danish Psychiatric Central Register (DPCR). The mean length of observation was 34.7 years, and the mean age at follow-up 35.8 (range: 28.3-46.7) years. RESULTS: At follow-up, 10 (2.1%) in the DLD group and two (0.09%) in the comparison group were known in the DPCR with a diagnosis of any ASD (P < 0.0001; odds ratio = 25.5; 95% confidence interval 5.5-116.9). CONCLUSION: Our results provide additional support to the notion that DLD is a marker of increased vulnerability to the development of ASD.
Asunto(s)
Trastornos Generalizados del Desarrollo Infantil/diagnóstico , Trastornos del Desarrollo del Lenguaje/diagnóstico , Adulto , Niño , Trastornos Generalizados del Desarrollo Infantil/epidemiología , Trastornos Generalizados del Desarrollo Infantil/etiología , Preescolar , Métodos Epidemiológicos , Femenino , Humanos , Trastornos del Desarrollo del Lenguaje/epidemiología , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
The prevalence and types of psychiatric disorders were studied in a clinical sample of 89 individuals with atypical autism (AA) first seen as children, and 258 matched controls from the general population using data from the nationwide Danish Psychiatric Central Register. The average observation time was 36.9 years, and mean age at follow-up 45.3 years. A total of 61 persons with AA (68.5%) had been in contact with psychiatric hospitals during the follow-up period, compared with 10.9% in the comparison group. A whole range of significantly elevated psychiatric disorders was found, so AA is not seen to be associated with any specific mental disorder. Schizophrenia spectrum disorders were the most commonly associated psychiatric disorders, diagnosed at least one time in 34.8% of the AA cases. Our findings underscore that it is important for clinicians working in adult psychiatric services to be aware that AA and a wide range of psychiatric disorders often co-exist.
Asunto(s)
Trastorno Autístico/epidemiología , Trastornos Mentales/epidemiología , Adolescente , Adulto , Edad de Inicio , Estudios de Casos y Controles , Niño , Preescolar , Comorbilidad , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Sotos syndrome, also known as cerebral gigantism, is a rare growth disorder first described by Sotos and colleagues in 1964. Since then, a majority of the literature pertaining to Sotos syndrome has focussed on the medical aspects of the syndrome, while neuropsychiatric issues have been given little attention. The present article presents a review of the current knowledge concerning neuropsychiatric aspects of Sotos syndrome. Information is provided relating to physical appearance, intellectual impairment, learning disabilities, language impairments, behavioural disorders and outcome. It is emphasised that careful delineation of neuropsychiatric aspects within a diagnostic syndrome may turn out to be the first step towards molecular characterisation of behaviour.
Asunto(s)
Anomalías Múltiples , Encefalopatías , Discapacidades del Desarrollo , Gigantismo , Adolescente , Trastornos de la Conducta Infantil , Preescolar , Humanos , Discapacidad Intelectual , Trastornos del Desarrollo del Lenguaje , Discapacidades para el Aprendizaje , Masculino , SíndromeRESUMEN
Although disintegrative psychosis (DP) was first described in 1908, the validity of the syndrome has not yet been fully documented. To investigate the validity of DP as defined in ICD-9, 13 cases of DP were compared with 39 cases of infantile autism with reference to lifetime parental psychopathology, neuroradiological findings and genetic abnormalities. The groups were matched for gender, age, intellectual level and social class. Apart from a significantly higher rate of electroencephalogram abnormalities in the disintegrative group there was very little in the neurobiological background to support a clear distinction between DP and infantile autism.
Asunto(s)
Trastorno Autístico/genética , Trastorno Autístico/fisiopatología , Encéfalo/fisiopatología , Trastornos Psicóticos/genética , Trastornos Psicóticos/fisiopatología , Trastorno Autístico/diagnóstico , Encéfalo/diagnóstico por imagen , Electroencefalografía , Femenino , Humanos , Masculino , Padres , Trastornos Psicóticos/diagnóstico , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Tomografía Computarizada por Rayos XRESUMEN
In order to study the validity of disintegrative psychosis (DP) as defined in ICD-9, we compared the natural history of somatic morbidity of 13 patients given this diagnosis in childhood with a control group of 39 patients with infantile autism (IA) matched for gender, age, IQ and social class. Average follow-up time was 22 and 23 (11-33) years, respectively. Significantly more DP patients (85 versus 41%) had been admitted to a non-psychiatric hospital during the follow-up period. They also had significantly more admissions (3.6 versus 1.0) and stayed longer in hospital (78 versus 4 days) than patients with IA. Three of the DP individuals had an associated medical disorder and made extensive use of somatic services during the follow-up period. Altogether the DP group had utilised the medical health care system more than patients with IA suggesting that they had more medical symptoms than the IA group. On the whole our findings suggest that individuals with DP and IA should be conceptualised as essentially distinct and should be studied separately as regards aetiology, pathophysiology, course and treatment.
Asunto(s)
Trastorno Autístico/complicaciones , Trastorno Autístico/psicología , Trastornos Psicóticos/complicaciones , Trastornos Psicóticos/psicología , Adulto , Niño , Preescolar , Femenino , Humanos , Masculino , Morbilidad , Reproducibilidad de los ResultadosRESUMEN
In order to study the validity of disintegrative psychosis (DP), the authors compared 13 patients given this diagnosis in childhood with a control group of 39 patients with infantile autism (IA) matched for sex, age, IQ and social class on measures of psychiatric morbidity. Almost the same proportion of the two groups had been admitted to a psychiatric hospital during a 22-year follow-up period. However, there was a slight tendency (statistically nonsignificant) for the DP group to utilize the psychiatric health care system more frequently than the IA group. They had more admissions and stayed longer in hospital than patients with IA suggesting that they had more psychiatric symptoms than the IA group. The original IA diagnoses were confirmed fairly consistently during the follow-up period, while the DP group was given more heterogenous diagnoses. No diagnosis of schizophrenia was made in either group.
Asunto(s)
Trastorno Autístico/complicaciones , Trastornos Psicóticos/epidemiología , Trastorno Autístico/diagnóstico , Trastorno Autístico/psicología , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Servicios de Salud Mental/estadística & datos numéricos , Morbilidad , Trastornos Psicóticos/etiología , Trastornos Psicóticos/terapiaRESUMEN
This study aimed to investigate the validity of disintegrative psychosis (DP) as defined in the ICD-9. The history of epilepsy in 13 subjects with DP was compared with that of 39 subjects with infantile autism (IA) who were matched for sex, age, IQ, and socioeconomic status (SES). The average follow-up time was 22 and 23 years (range 11 to 33 years). A significant difference was found between the DP and IA groups in terms of incidence of epilepsy, 77% versus 33% respectively. The peak period of onset of epilepsy occurred before puberty in both groups. Different types of epilepsy were seen, but the psychomotor variant accounted for 50% in the DP group, while 46% of the IA group had the psychomotor and 62% had the grand mal variant. The types are not mutually exclusive. Individuals without epilepsy had significantly higher IQ scores than those with epilepsy, but only within the IA group. The increased risk of developing epilepsy in the DP group is most likely a reflection of an underlying early brain pathology probably present in most individuals with DP. On the whole our findings can be seen as a contribution to the validation of DP as separate from IA, as these two conditions could be distinguished in terms of the way they develop with reference to epilepsy.
Asunto(s)
Trastorno Autístico/diagnóstico , Trastornos Psicóticos/diagnóstico , Adolescente , Adulto , Trastorno Autístico/epidemiología , Trastorno Autístico/etiología , Daño Encefálico Crónico/diagnóstico , Daño Encefálico Crónico/epidemiología , Daño Encefálico Crónico/etiología , Niño , Preescolar , Comorbilidad , Dinamarca , Epilepsia/diagnóstico , Epilepsia/epidemiología , Epilepsia/etiología , Femenino , Estudios de Seguimiento , Humanos , Lactante , Discapacidad Intelectual/diagnóstico , Discapacidad Intelectual/epidemiología , Discapacidad Intelectual/etiología , Inteligencia , Masculino , Admisión del Paciente/estadística & datos numéricos , Trastornos Psicóticos/epidemiología , Trastornos Psicóticos/etiología , Factores de RiesgoRESUMEN
BACKGROUND: Empirical evidence for the validity of the diagnostic label disintegrative psychosis is sparse. The issue of whether it is a separate form of infantile autism is unresolved. METHOD: To investigate the validity of disintegrative psychosis as defined in ICD-9, the natural history of 13 cases were compared with 39 matched cases of infantile autism on various outcome variables. Average follow-up time was 22 (11-33) years. RESULTS: Statistically significant differences were found between the two groups in terms of number of admissions to non-psychiatric departments, occurrence of comorbid epilepsy, social style, and score on the Global Assessment of Functioning scale. In most other areas assessed there was a tendency, although statistically insignificant, towards a better outcome in the infantile autism comparison group. CONCLUSIONS: Our findings provide some support for maintaining a diagnostic category of disintegrative psychosis as distinct from infantile autism.
Asunto(s)
Trastorno Autístico/diagnóstico , Trastornos Psicóticos/diagnóstico , Actividades Cotidianas , Adulto , Trastorno Autístico/complicaciones , Trastorno Autístico/epidemiología , Trastorno Autístico/psicología , Niño , Preescolar , Dinamarca/epidemiología , Escolaridad , Epilepsia/complicaciones , Femenino , Estudios de Seguimiento , Humanos , Inteligencia , Relaciones Interpersonales , Masculino , Pensiones , Trastornos Psicóticos/complicaciones , Trastornos Psicóticos/epidemiología , Trastornos Psicóticos/psicología , Pubertad , Características de la ResidenciaRESUMEN
This follow-up study reports data on 18 children fulfilling the ICD-10 criteria for childhood autism (n = 9) and Asperger syndrome (n = 9). In connection with the present study the original child psychiatric records were reassessed according to the ICD-10 criteria. The children were followed over a period of 30 years. The mean age at the time of study was 38 years. The results show that in adulthood the autistic patients had a poorer outcome than children with Asperger syndrome as regards education, employment, autonomy, marriage, reproduction and the need for continuing medical and institutional care. Particular attention is given to pharmacotherapy and the relationship between the childhood disorder and psychiatric morbidity in adult life.
Asunto(s)
Trastorno Autístico , Trastornos Generalizados del Desarrollo Infantil , Adolescente , Adulto , Antipsicóticos/uso terapéutico , Trastorno Autístico/tratamiento farmacológico , Trastorno Autístico/epidemiología , Trastorno Autístico/psicología , Trastorno Autístico/rehabilitación , Niño , Trastornos Generalizados del Desarrollo Infantil/tratamiento farmacológico , Trastornos Generalizados del Desarrollo Infantil/epidemiología , Trastornos Generalizados del Desarrollo Infantil/psicología , Trastornos Generalizados del Desarrollo Infantil/rehabilitación , Dinamarca/epidemiología , Empleo , Femenino , Estudios de Seguimiento , Humanos , Masculino , Estado Civil , Trastornos Mentales/complicaciones , Persona de Mediana Edad , Características de la Residencia , Ajuste Social , Seguridad Social/estadística & datos numéricos , Resultado del TratamientoRESUMEN
Neurofibromatosis is a devasting autosomal dominant disease which is extremely variable in its symptomatology, intensity, and progression. There have been numerous reports published about the physical aspects of neurofibromatosis, while psychological issues have been given little attention so far. The present article presents a review of the current knowledge concerning psychological aspects of neurofibromatosis. Information is provided relating to physical appearance, intellectual impairment, neuropsychological findings, learning disability, and psychiatric disorders.
Asunto(s)
Neurofibromatosis 1/psicología , Psiquiatría Biológica , Humanos , Discapacidades para el Aprendizaje , NeuropsicologíaRESUMEN
The Landau-Kleffner syndrome or the syndrome of acquired epileptic aphasia was first described in 1957. The disorder is characterised by gradual or rapid loss of language in a previously normal child. All children have abnormal EEG compatible with the diagnosis of epilepsy, however, only 70% have clinical seizures. The present article presents a review of the current knowledge concerning this disorder. Information is provided related to the clinical picture, etiology, pathogenesis, treatment and outcome.
Asunto(s)
Síndrome de Landau-Kleffner/diagnóstico , Edad de Inicio , Encéfalo/fisiopatología , Niño , Preescolar , Electroencefalografía , Epilepsia/diagnóstico , Epilepsia/fisiopatología , Humanos , Síndrome de Landau-Kleffner/etiología , Síndrome de Landau-Kleffner/fisiopatología , Trastornos del Lenguaje/terapia , LogopediaRESUMEN
Season of birth in 328 children with infantile autism and other types of childhood psychoses born between 1945 and 1980 was compared with that of a control population born in the same period. For some parts of the period (the years 1951-56, 1963-68 and 1975-80 combined) an excess of March born boys with infantile autism was found. For boys with autistic-like disorders, born in the same period a maximum occurred in November, while no seasonality was observed for a borderline sample.
Asunto(s)
Trastorno Autístico/epidemiología , Trastornos Psicóticos/epidemiología , Estaciones del Año , Adolescente , Trastorno Autístico/etiología , Trastorno de Personalidad Limítrofe/epidemiología , Trastorno de Personalidad Limítrofe/etiología , Niño , Preescolar , Dinamarca/epidemiología , Femenino , Humanos , Masculino , Trastornos Psicóticos/etiología , Factores de RiesgoAsunto(s)
Trastorno Autístico/etiología , Trastorno de Personalidad Limítrofe/etiología , Daño Encefálico Crónico/etiología , Edad Materna , Trastornos Neurocognitivos/etiología , Edad Paterna , Trastorno Autístico/diagnóstico , Trastorno Autístico/psicología , Trastorno de Personalidad Limítrofe/diagnóstico , Trastorno de Personalidad Limítrofe/psicología , Daño Encefálico Crónico/diagnóstico , Daño Encefálico Crónico/psicología , Niño , Preescolar , Femenino , Humanos , Inteligencia , Masculino , Trastornos Neurocognitivos/diagnóstico , Trastornos Neurocognitivos/psicología , Factores de Riesgo , Clase SocialRESUMEN
We present a 5-year-old boy with Landau-Kleffner syndrome, whose clinical manifestations were very similar to cases previously reported in the literature. CT and MRI scan failed to document any morphological abnormalities of his brain. However, high resolution rCBF imaging by HMPAO and SPECT demonstrated relatively low-flow areas in the left middle frontal gyrus and the right mesiotemporal/hippocampal region corresponding to the localization of EEG changes.
Asunto(s)
Encefalopatías/fisiopatología , Encéfalo/fisiopatología , Síndrome , Afasia/complicaciones , Afasia/fisiopatología , Encéfalo/irrigación sanguínea , Encéfalo/patología , Encefalopatías/diagnóstico por imagen , Encefalopatías/patología , Circulación Cerebrovascular , Preescolar , Lóbulo Frontal/metabolismo , Lóbulo Frontal/fisiopatología , Lateralidad Funcional , Hipocampo/metabolismo , Hipocampo/fisiopatología , Humanos , Masculino , Enfermedades Metabólicas/metabolismo , Enfermedades Metabólicas/fisiopatología , Radiografía , Trastornos del Habla/complicaciones , Tomografía Computarizada de Emisión de Fotón ÚnicoRESUMEN
Recent findings have suggested that the simultaneous occurrence of neurofibromatosis and childhood psychosis might be more than a coincidence. In this study of 341 children with infantile autism and other types of childhood psychosis seen as inpatients in two university clinics of child psychiatry in a 25-year period, only one case (0.3%) of concomitant occurrence of the disorders was found, which is a frequency no higher than expected by chance.
Asunto(s)
Trastorno Autístico/complicaciones , Neurofibromatosis 1/complicaciones , Trastornos Psicóticos/complicaciones , Trastorno Autístico/epidemiología , Comorbilidad , Dinamarca/epidemiología , Femenino , Humanos , Lactante , Masculino , Neurofibromatosis 1/epidemiología , Trastornos Psicóticos/epidemiologíaRESUMEN
During the last three decades the psychological consequences of precocious puberty have received considerable attention. The nature and shortcomings of relevant studies are described. It is emphasized that specialized counselling and guidance of families with children who have to cope with precocious puberty is important, since it often contributes to an appropriate behaviour adjustment without the development of psychiatric symptomatology. Guidelines for medical service and psychological management are provided.
Asunto(s)
Desarrollo Infantil , Desarrollo Psicosexual , Pubertad Precoz/psicología , Niño , Emociones , Femenino , Humanos , Inteligencia , MasculinoRESUMEN
The syndrome of reversible somatotropin deficiency (psychosocial dwarfism) is characterized by environment-related impairment of stature and mental growth and growth-hormone secretion. The syndrome is well illustrated by this case report of an eight-year-old boy with psychosocial dwarfism since the third year of life. It was undetected for four years, despite his having been in regular contact with a number of health workers. After he was removed from the deleterious environment, both his growth and behaviour improved markedly, and at follow-up he had maintained this progress.