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1.
Clin Implant Dent Relat Res ; 25(1): 133-140, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36190150

RESUMEN

INTRODUCTION: Implant stability is influenced by bone density, implant design, and site preparation characteristics. Piezoelectric implant site preparation (PISP) has been demonstrated to improve secondary stability compared with conventional drilling techniques. Osseodensification drills (OD) have been recently introduced to enhance both bone density and implant secondary stability. The objective of the present multi-center prospective randomized controlled trial was to monitor implant stability changes over the first 90 days of healing after implant bed preparation with OD or PISP. METHODS: Each patient received two identical, adjacent or contralateral implants in the posterior maxilla. Following randomization, test sites were prepared with OD and control sites with PISP. Resonance frequency analysis was performed immediately after implant placement and after 7, 14, 21, 28, 60, and 90 days. Implants were then restored with single screw-retained metal-ceramic crowns and followed for 12 months after loading. RESULTS: Twenty-seven patients (15 males and 12 females; mean age 63.0 ± 11.8 years) were included in final analysis. Each patient received two identical implants in the posterior maxilla (total = 54 implants). After 1 year of loading, 53 implants were satisfactorily in function (one failure in test group 28 days after placement). Mean peak insertion torque (40.7 ± 12.3 Ncm and 39.5 ± 10.2 Ncm in test and control group, respectively) and mean implant stability quotient (ISQ) value at baseline (71.3 ± 6.9 and 69.3 ± 7.6 in test and control group, respectively) showed no significant differences between the two groups. After an initial slight stability decrease, a shift to increasing ISQ values occurred after 14 days in control group and after 21 days in test group, but with no significant differences in ISQ values between the two groups during the first 90 days of healing. CONCLUSION: No significant differences in either primary or secondary stability or implant survival rate after 1 year of loading were demonstrated between implants inserted into sites prepared with OD and PISP.


Asunto(s)
Implantes Dentales , Carga Inmediata del Implante Dental , Masculino , Femenino , Humanos , Persona de Mediana Edad , Anciano , Implantación Dental Endoósea/métodos , Estudios Prospectivos , Carga Inmediata del Implante Dental/métodos , Cicatrización de Heridas
2.
Materials (Basel) ; 15(14)2022 Jul 12.
Artículo en Inglés | MEDLINE | ID: mdl-35888326

RESUMEN

Background: tooth extraction is a common procedure in oral surgery. The socket healing process involves hard and soft tissues and is characterized by intense remodeling, which may determine consistent dimension changes. Several autologous platelet concentrates (APCs) proved to be effective for enhancing alveolar socket healing after tooth extraction, accelerating socket closure and countering alveolar bone resorption. Concentrated growth factors (CGFs) are one of the most recently developed APCs, and their effect on the socket healing process still needs to be confirmed. Aim: The aim of the present split-mouth study was to evaluate the effectiveness of CGFs in enhancing the healing process in the postextraction alveolar socket and reducing postoperative pain. Methods: One hundred and fifty-four extractions were performed. One of the extraction sockets of each patient was treated with CGFs (test site), and the other socket was unfilled (control site). The main outcomes were: healing index, alveolar dimensions at the crestal level, socket closure, and pain perception. Descriptive statistics of the results were analyzed. Follow-up data were compared to baseline using paired tests. Results: The healing index on day 7 was significantly better (p < 0.001) in the test group (5.01 ± 1.30) as compared to the control group (6.65 ± 1.41). The mean visual analog scale for pain (VAS) was significantly higher for the control group when compared to the CGF group in the first 5 days postextraction. There was a trend toward greater socket closure in the CGF group, indicating faster healing, as compared to the control group at 7, 14, and 21 days. Conclusions: CGFs can represent a useful adjunctive tool, considering their mechanical and biological properties, for improving alveolar socket healing and reducing postoperative patient discomfort.

3.
Materials (Basel) ; 14(11)2021 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-34064086

RESUMEN

BACKGROUND: Platelet concentrates are biological, autologous products obtained from the patient's whole blood, consisting of a supraphysiological concentration of platelets and growth factors, that have proved beneficial in different applications in the medical and dental fields. They are used in several medical and dental applications to enhance tissue healing. Previous evidence shows that platelet concentrates may be beneficial in patients with compromised systemic conditions, in which the healing process is impaired. AIM: To evaluate the 5-year clinical outcome of implant treatment using acid-etched implants with calcium ions-modified surface in association with plasma rich in growth factors, in patients with systemic diseases of a different nature. METHODS: Charts of 99 medically compromised patients, who had received a total of 224 dental implants from January 2013 to June 2013, were retrospectively evaluated. Patients were divided into four groups, according to their condition: diabetes (n = 39 patients), osteoporosis (n = 36), lupus erythematosus systemic (n = 5), rheumatoid arthritis (n = 19). The main outcomes were implant survival, marginal bone level (MBL) change and complications throughout follow-up. RESULTS: Mean follow-up was 63.06 ± 1.90 months (range 60.1 to 66.4 months). In total, eight implants failed in 6 diabetic patients and 4 in 3 patients with rheumatoid arthritis. Overall 5-year implant survival was 94.6%. In total, 30 complications occurred in 24 patients, mostly transient, and no severe adverse event occurred. Overall MBL change was 0.45 ± 0.12 mm, with no significant differences among groups. CONCLUSIONS: In the present sample of medically compromised patients, rehabilitation with calcium ions-modified surface implants associated with plasma rich in growth factors proved to be a safe and effective treatment. The satisfactory results achieved after 5-year follow-up are comparable to those historically reported for healthy patients.

4.
J Oral Implantol ; 47(3): 205-213, 2021 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-32780812

RESUMEN

Inserting zygomatic implants is a challenging surgery and requires special care and great precision. Piezoelectric surgery offers several advantages: more precise bone cutting with improved intraoperative visibility and a low temperature increase. The aim of this case-control study was to evaluate whether ultrasonic instruments can be as effective as standard drilling instruments for zygomatic implant surgery in terms of clinical outcomes. Ninety-two patients with atrophic maxilla were included in the study. Implant sites were prepared with the ultrasonic technique (test group = 47 patients) or traditional drilling (control group = 45 patients). In total, 368 zygomatic implants were inserted (202 with the extrasinus technique, 77 with the sinus slot technique, and 89 with the Brånemark technique). Complete arch provisional prostheses were delivered 3 to 5 hours after the surgical operations. The mean follow-up after surgery was 24 months (range = 12-32 months). The primary outcome evaluations were based on implant survival rates and postoperative complications. Operative time and surgeon's stress were evaluated as secondary outcomes. Implant survival rate was 100% in the test and 98.89% in the control group. Postoperative complications were seen in 9 patients (4 in the test and 5 in the control group); the difference was not statistically significant. Operative time was longer in the test group; however, surgeons were more comfortable using ultrasonic instruments. Within the limitations of this preliminary study, the ultrasonic technique was a feasible alternative to traditional drilling for zygomatic implant surgery.


Asunto(s)
Implantes Dentales , Arcada Edéntula , Estudios de Casos y Controles , Implantación Dental Endoósea , Prótesis Dental de Soporte Implantado , Estudios de Seguimiento , Humanos , Arcada Edéntula/cirugía , Maxilar/cirugía , Resultado del Tratamiento , Ultrasonido , Cigoma/cirugía
7.
J Craniofac Surg ; 28(4): 1042-1045, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28178105

RESUMEN

OBJECTIVE: The aim of the present study was to evaluate the efficacy of biomimetic composite bone substitute composed of equine collagen I and Mg-hydroxyapatite in improving socket preservation after tooth extraction in humans. METHODS: Thirty-two patients were subjected to a single tooth extraction, performed without elevation of the full-thickness flap. In each patient, socket was grafted with the bone substitute and specimens were retrieved 2 months after surgery and processed for histological observations. The clinical outcome variables were healing index, visual analog score for pain, postsurgery complications, and patient satisfaction evaluated through a questionnaire. RESULTS: No adverse reaction or infection occurred, in which healing index averaged 5.8 (range 4-7). Pain scores were lower. The patients' questionnaire outcomes were unanimously in favor of the test treatment. At low-power magnification, it was possible to see a portion of native bone with small marrow spaces and many areas of bone remodeling. At high-power magnification, it could be observed that small newly formed trabeculae originated from the preexisting bone and bone spicules in the middle of the defect. CONCLUSION: Grafting the postextraction socket with composite bone substitute may improve the healing process by accelerating socket closure and tissue maturation. Such a product demonstrated excellent biocompatibility as no inflammatory reaction could be detected histologically and was well accepted by patients.


Asunto(s)
Materiales Biomiméticos/uso terapéutico , Sustitutos de Huesos/uso terapéutico , Colágeno/uso terapéutico , Durapatita/uso terapéutico , Extracción Dental , Alveolo Dental/cirugía , Adulto , Anciano , Animales , Remodelación Ósea , Femenino , Caballos , Humanos , Masculino , Persona de Mediana Edad , Colgajos Quirúrgicos , Cicatrización de Heridas
8.
J Craniofac Surg ; 27(5): 1215-9, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27391492

RESUMEN

OBJECTIVE: The purpose of this investigation was to evaluate the therapeutic efficacy of superpulsed, low-level laser therapy (SLLLT) on neurosensory recovery of the inferior alveolar nerve (IAN) after oral surgical injury. BACKGROUND DATA: A survey of the literature reveals the uncertainty of outcomes for the surgical management of IAN injury and the efficacy of low-level laser therapy in the treatment of IAN injury. METHODS: In this study, the authors report the results for SLLLT in 57 patients affected by paresthesia of the lip, chin, gingival, and buccal regions. Each patient was subjected to 10 laser treatments, once a week, with a GaAs diode laser. Clinical neurosensory tests (soft touch, 2-point discrimination, pin prick, thermal test) and the visual analogue scale were used before every treatment to evaluate the extent of neurosensory recovery. RESULTS: The authors' results demonstrate that 83.3% of the patients had a significant neurosensory recovery, as evident in the objective and subjective tests. CONCLUSION: The results reported in this study indicate that SLLLT has the potential to improve neurosensory recovery in patients with IAN paresthesia.


Asunto(s)
Mentón/inervación , Terapia por Luz de Baja Intensidad/métodos , Nervio Mandibular/efectos de la radiación , Procedimientos Quirúrgicos Orales/métodos , Recuperación de la Función , Sensación/fisiología , Traumatismos del Nervio Trigémino/radioterapia , Adulto , Femenino , Humanos , Masculino , Nervio Mandibular/fisiopatología , Persona de Mediana Edad , Traumatismos del Nervio Trigémino/fisiopatología
9.
J Craniofac Surg ; 27(3): 685-90, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-27159857

RESUMEN

The purpose of this study was to evaluate anti-inflammatory and analgesic efficacy of superpulsed low level laser therapy (SLLLT) after bilateral extraction of impacted mandibular third molars. Many studies in the literature show the anti-inflammatory and analgesic efficacy of laser therapy after oral surgery.The authors report the preliminary results of 25 patients who underwent bilateral extraction of mandibular eighths included in a single surgery. This is a split-mouth study, a site was randomized chosen to be treated with SLLLT at T0, 24 hours and 48 hours with a GaAs laser diode, whereas the other surgical site was evaluated as control. The suture was removed at 7 days and healing was controlled at 14 days. During the sessions were monitored and recorded the pain, using visual analog scale, and oedema with the visual analog scale and cephalometric measurements of cutaneous points (TR-GO, GO-CA, GO-SP, GO-PO). Each patient received only antibiotic prophylaxis and analgesic therapy as needed.Results indicate that in the treated site SLLLT determines a reduction in pain and swelling statistically significant compared with the control site (P < 0.05). The authors found that the effectiveness of laser therapy is in the first 5 days after surgery, showing a significant reduction of pain and swelling in the treated site than the control site.This study suggests that the SLLLT has a potential in reducing the postoperative discomfort after impacted third molar extractions, due to a reduction in postoperative pain and swelling. Superpulsed low level laser therapy has no side effects and is well tolerated by patients. It also seems to have a role in reducing the intake of drugs.


Asunto(s)
Analgesia/métodos , Inflamación/terapia , Terapia por Luz de Baja Intensidad/métodos , Tercer Molar/cirugía , Dolor Postoperatorio/terapia , Extracción Dental , Diente Impactado/cirugía , Adulto , Edema/terapia , Femenino , Humanos , Masculino , Mandíbula/cirugía , Dimensión del Dolor
10.
J Craniofac Surg ; 27(3): 691-6, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-27046472

RESUMEN

BACKGROUND AND AIM: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients. METHODS: A randomized split-mouth design was used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months. RESULTS: Test group showed a statistically significant improvement for probing depth (P = 0.002), clinical attachment level (P = 0.001), and radiographic defect depth (P < 0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19 ±â€Š13.24% in the test group as compared with 24.86 ±â€Š9.94% reduction in the control group. CONCLUSIONS: The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.


Asunto(s)
Pérdida de Hueso Alveolar/cirugía , Plaquetas , Fibrina/uso terapéutico , Regeneración Tisular Guiada Periodontal/métodos , Pérdida de la Inserción Periodontal/cirugía , Adulto , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Trasplante Autólogo , Resultado del Tratamiento
11.
J Craniofac Surg ; 26(3): 709-13, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25974777

RESUMEN

The objective of this study was to evaluate the effectiveness of the temporomandibular joint (TMJ) osteoarthritis treatment through articular injections of plasma rich in growth factors (PGRF)-Endoret. Thirteen patients (median age, 47.64 y; SD, 7.51; range, 40-64 y; male-female ratio, 2:11) with osteoarthritis of TMJ associated to chronic pain have been selected. They were treated with articular injections of PRGF-Endoret, measuring the maximum mouth opening and pain level before the first injection (t0), 30 days after just before the second (t1), and after 6 months (t2). Data were analyzed using the paired Student's t-test data. The visual analogue scale score at t0 is 7.69 (range, 4-10; SD, 1.9), whereas that at t1 is 1.54 (range, 0-5; SD, 1.74) and that at t2 is 0.23 (range, 0-2; SD, 0.65). These differences in the results are statistically highly significant (P < 0.0001 comparison t0-t1 and t0-t2 and P < 0.01 comparison t1-t2). In terms of maximum mouth opening, it reduced from 30.15 mm at t0 (range, 26-40 mm; SD, 4.44) to 37.54 mm at t1 (range, 31-51 mm; SD, 5.10), with an increase of 7.38 mm (range, 4-11 mm; SD, 2.02) and a highly significant difference (P < 0.0001). At t2, it was 39.54 mm (range, 34-51; SD, 4.55) with an increase of 9.38 mm (range, 5-12 mm; SD, 2.21) compared with t0 and that of 2.00 mm compared with t1. Both differences in the results are statistically significant (P < 0.0001 and P < 0.01, respectively). The articular injections of PRGF-Endoret represent a very efficient method to control pain and to improve the TMJ mobility.


Asunto(s)
Péptidos y Proteínas de Señalización Intercelular/administración & dosificación , Trastornos de la Articulación Temporomandibular/terapia , Adulto , Femenino , Humanos , Inyecciones Intraarticulares , Masculino , Persona de Mediana Edad , Articulación Temporomandibular
12.
J Craniofac Surg ; 26(3): 722-8, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25974779

RESUMEN

When the residual bone crest cannot allow the placement of standard implants, the treatment for complete arch rehabilitation of severely atrophic maxillae can be performed with 4 zygomatic implants (ZIs) and immediate function with predictable results in terms of aesthetics, function, and comfort for the patient. However, even if ZIs' rehabilitations showed a good success rate, this surgery is difficult and need a skillful operator. Complications in this kind of rehabilitation are not uncommon; the main difficulties can be related to the reduced surgical visibility and instrument control in a critical anatomic area. All the surgical protocols described in the literature used drilling techniques. Furthermore, the use of ultrasonic instruments in implant surgery compared with drilling instruments have shown advantages in many aspects of surgical procedures, tissues management, enhancement of control, surgical visualization, and healing. The aim of this study was to report on the preliminary experience using ultrasound technique for ZIs surgery in terms of safety and technical improvement. Ten consecutive patients with severely atrophic maxilla have been treated with 4 ZIs and immediate complete arch acrylic resin provisional prostheses. The patients were followed up from 30 to 32 months evaluating implant success, prosthetic success, and patient satisfaction with a questionnaire. No implants were lost during the study period, with a 100% implant and prosthetic success rate. Within the limitations of this preliminary study, these data indicate that ultrasonic implant site preparation for ZIs can be a good alternative to the drilling technique and an improvement for the surgeon.


Asunto(s)
Implantación Dental Endoósea/métodos , Prótesis Dental de Soporte Implantado , Arcada Edéntula/cirugía , Cigoma/cirugía , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Arcada Edéntula/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Ultrasonografía , Cigoma/diagnóstico por imagen
13.
J Craniofac Surg ; 26(3): 731-6, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25974781

RESUMEN

OBJECTIVES: Osteoradionecrosis (ORN) is the worst long-term complication due to radiotherapy to the head and neck and is defined as an area of exposed necrotic oral bone, with failure to heal for at least 3 months. In most cases, ORN is associated with oral surgery procedures involving the jaw bone. The aim of this study was to evaluate the safety and effectiveness of a biological approach for ORN treatment. METHODS: A series of 10 patients with ORN were treated by debridement of necrotic bone using an ultrasound device followed by application of plasma rich in growth factors (PGRF)-Endoret to improve and accelerate soft-tissue healing. Patients were followed clinically and radiographically up to 12 months. Pain was assessed in the first week postsurgery using a visual analogue scale (VAS). Maturation and quality of tissue healing was assessed using a modified healing index. RESULTS: All cases were successfully treated. No intraoperative or postoperative complications occurred. Clinical and radiographic evaluations showed no signs of persistent infection or exposed bone up to 12 months of follow-up. The maturity and quality of the regenerated tissues was excellent, surgical wounds always achieving complete closure. VAS scores and trismus were very low in all patients, which did not take analgesics since the third day after surgery. CONCLUSIONS: PRGF-Endoret is beneficial, as an adjunct to surgical treatment of osteoradionecrosis, for predictable enhancement of tissue vascularization and epithelialization in patients with a history of head and neck radiotherapy.


Asunto(s)
Desbridamiento/métodos , Péptidos y Proteínas de Señalización Intercelular/farmacología , Osteorradionecrosis/terapia , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cicatrización de Heridas
14.
J Craniofac Surg ; 26(3): 749-55, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25974785

RESUMEN

There is disagreement as to whether it is safe to place implants in patients under bisphosphonates (BPs) therapy owing to the risk for developing BP-related osteonecrosis of the jaws (BRONJ). The American Association of Oral and Maxillofacial Surgeons recommends that dental implants should be avoided in oncologic patients treated with intravenous BPs. Conversely, for patients receiving oral BPs, dental implant placement is not explicitly contraindicated even if a cautious approach is suggested. The aim of the current study was to assess the risk level as related to adverse events such as implant failure and BRONJ in a large cohort of osteoporotic patients submitted to implant placement and concomitant application of plasma rich in growth factor (PGRF)-Endoret. The clinical charts of 235 middle-aged women under oral BPs therapy for osteoporosis, who underwent positioning of 1267 dental implants, were reviewed. The implants were always positioned in association with PRGF-Endoret. The outcomes were implant failure and BRONJ. A model based on personal risk factors distribution was used for risk assessment. Sixteen implants were lost in 16 patients up to 120 months of follow-up, leading to a survival of 98.7% and 93.2% on an implant basis and patient basis, respectively. No cases of BRONJ were reported. In line with the current literature, the present data show that the risk for developing BRONJ associated to dental implant surgery remains low for patients receiving oral BPs. The use of procedures that could enhance and support healing, such as platelet concentrates, should be recommended.


Asunto(s)
Productos Biológicos/administración & dosificación , Fracaso de la Restauración Dental , Difosfonatos/efectos adversos , Péptidos y Proteínas de Señalización Intercelular/administración & dosificación , Enfermedades Maxilomandibulares/inducido químicamente , Osteonecrosis/inducido químicamente , Osteoporosis Posmenopáusica/complicaciones , Osteoporosis Posmenopáusica/tratamiento farmacológico , Anciano , Conservadores de la Densidad Ósea/efectos adversos , Diseño de Implante Dental-Pilar , Difosfonatos/administración & dosificación , Femenino , Humanos , Persona de Mediana Edad , Oseointegración/efectos de los fármacos , Medición de Riesgo
15.
J Craniofac Surg ; 26(3): 772-5, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25915670

RESUMEN

Denture-induced fibrous hyperplasia is a fibrous connective tissue lesion that commonly occurs in oral mucosa in patients showing important alveolar ridge atrophy. In this study, we propose Plasma Rich in Growth Factors (PRGF) to overcome constrains of traditional surgical treatment. Herein, we demonstrated that PRGF represents an autologous source of growth factors able to reduce the healing time of the alveolar mucosa and the discomfort of those patients. These properties are the result of PRGF's precise biological features that result in the following: reduction of duration and intensity of postsurgical pain, acceleration of re-epithelialization of the wound, and reduction of bleeding events and of edema. In conclusion, we showed that using PRGF on patients affected by denture-induced fibrous hyperplasia allows a short healing time, thereby reducing complications and overall improving their quality of life. The aims of this study were to evaluate the influence of PRGF-ENDORET on secondary re-epithelialization in vestibuloplasty after excision of denture irritation fibrous hyperplasia, with an explorative randomized case control trial with 10 patients, 5 patients treated with PRGF and 5 patients with traditional hemostasis, and to analyze differences with simple surgery, considering postoperative rapidity of re-epithelialization, comfort, and discomfort of patients, pain, swelling, and infections.


Asunto(s)
Pérdida de Hueso Alveolar/tratamiento farmacológico , Proceso Alveolar/efectos de los fármacos , Proceso Alveolar/patología , Productos Biológicos/administración & dosificación , Dentadura Completa/efectos adversos , Péptidos y Proteínas de Señalización Intercelular/administración & dosificación , Adulto , Anciano , Terapia Combinada , Femenino , Humanos , Hiperplasia/tratamiento farmacológico , Hiperplasia/patología , Masculino , Persona de Mediana Edad , Repitelización/efectos de los fármacos , Vestibuloplastia
16.
Eur J Cancer ; 51(1): 62-74, 2015 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25466505

RESUMEN

PURPOSE: Bisphosphonate related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction consisting of progressive bone destruction in the maxillofacial region of patients under current or previous treatment with a bisphosphonate. Autologous platelet concentrates (APC) demonstrated to enhance bone and soft tissue healing in oral surgery procedures. The present systematic review aimed at evaluating if APC may improve treatment and prevention of BRONJ in patients under bisphosphonate therapy. METHODS: MEDLINE, Scopus and Cochrane databases were searched using terms like bisphosphonates, osteonecrosis, BRONJ, platelet concentrate, PRP, PRF, PRGF. No language, publication date and study design limitation was set. A hand search of the bibliographies of identified articles was also performed. The primary outcome was recurrence/onset of BRONJ after oral surgery procedures. RESULTS: Eighteen studies were included, reporting on 362 patients undergoing oral surgery in combination with APC. The adjunct of APC in BRONJ treatment significantly reduced osteonecrosis recurrence with respect to control. APC was associated with a lower BRONJ incidence after tooth extraction, though not significant. Heterogeneity was found regarding bisphosphonate type, clinical indication, treatment duration, triggering factors, study design, follow-up duration, type of APC, outcomes adopted to evaluate treatment success. CONCLUSION: Though the results of this review must be cautiously interpreted, due to the low evidence level of the studies included, and the limited sample size, they are suggestive of possible benefits of APC when associated with surgical procedures for treatment or prevention of BRONJ. To confirm such indication, prospective comparative studies with a large sample size are urgently needed.


Asunto(s)
Osteonecrosis de los Maxilares Asociada a Difosfonatos/prevención & control , Osteonecrosis de los Maxilares Asociada a Difosfonatos/terapia , Plaquetas/metabolismo , Difosfonatos/efectos adversos , Difosfonatos/uso terapéutico , Femenino , Humanos , Masculino , Resultado del Tratamiento
17.
Blood Transfus ; 13(2): 287-94, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25369587

RESUMEN

BACKGROUND: Dental extractions in haemophiliacs may cause secondary bleeding, requiring repeated surgical and haematological interventions. As a local haemostatic, fibrin glue has recognised efficacy but, as a plasma-derived product, it carries the risk of viral infections. We, therefore, compared fibrin glue with an autologous haemostatic, plasma rich in growth factors (PRGF), in a controlled trial. MATERIAL AND METHODS: One hundred and twenty patients with different blood disorders were randomised into two cohorts to undergo dental extraction procedures without hospitalisation. Prior to the extractions, patients underwent systemic haematological treatment. Complications were defined as secondary bleeding after the 7-day follow-up period or protracting after the repair procedure. RESULTS: There were 106 extractions (7 retained 3(rd) molars) in the group managed with fibrin glue: secondary bleeding affected 3/60 patients (5%) on the third day after extraction and necessitated additional surgery and systemic treatment (in one case the procedure had to be repeated on the 7(th) day). In the PRGF arm there were 98 extractions (23 retained 3(rd) molars): secondary bleeding affected two patients (3.3%) on the first day after extraction and was arrested with surgery without systemic treatment. Four out of the five secondary bleeds occurred in patients with haemophilia A. Concomitant diabetes or liver disease significantly increased the bleeding risk. DISCUSSION: The bleeding rates in the study and control arm prove that PRGF works as well as fibrin glue as a local haemostatic. Further assets are that PRGF has autologous origin, does not require additional systemic treatment in post-extraction repair surgery, is associated with an earlier onset of neo-angiogenesis and, overall, can reduce patients' distress and costs to the health system.


Asunto(s)
Trastornos de la Coagulación Sanguínea , Pérdida de Sangre Quirúrgica/prevención & control , Transfusión de Sangre Autóloga , Plasma , Extracción Dental , Adolescente , Adulto , Anciano , Niño , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Factores de Tiempo
18.
J Oral Implantol ; 41(4): 437-43, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-24175951

RESUMEN

The aim of this paper is to retrospectively assess the long-term clinical and radiological results in a group of patients treated with Brånemark TiUnite implants supporting mostly single-tooth and partial restorations. The clinical records of 90 consecutive patients (mean age 55.9 years; range 21-82 years), treated with 209 Brånemark System MkIII or MkIV TiUnite implants (72 maxillary/137 mandibular; 26 anterior intercanine/183 posterior sites), were analyzed. Indication types were single tooth (n = 21 implants), partial (n = 180) and full arches (n = 8). A delayed loading protocol was applied in 128 implants, while 81 were immediately loaded. Cumulative survival rate and marginal bone remodeling were evaluated. Marginal bone level was evaluated by an independent radiologist from periapical radiographs taken at implant insertion and at long-term follow up. Plaque, probing pocket depth and peri-implant mucosa conditions were also assessed. The results showed the mean follow-up duration was 11.0 years (range 9.6-12.4 years): 181 implants (90.5%) reached at least 10 years follow-up, 100 implants 11 years, and 17 implants 12 years. Overall, 6 implants failed in 4 patients (5 during the first year and 1 after 2 years) resulting in a 97.1% survival rate after 12 years. Mean bone levels at implant insertion and at the last follow up were -0.90 ± 1.16 mm (mean ± SD; n = 169) and -1.49 ± 0.95 mm (n = 195), respectively. Mean marginal bone remodeling from implant insertion to the last follow-up was -0.60 ± 1.17 mm (n = 168). At the last available follow-up, mean pocket depth was 1.65 ± 0.84 mm. Peri-implant mucosa was normal for the majority (97%) of implants. In conclusion, this retrospective long-term study showed excellent survival rate of TiUnite implants as well as favorable marginal bone response and soft tissue conditions.


Asunto(s)
Pérdida de Hueso Alveolar , Implantes Dentales , Diseño de Prótesis Dental , Titanio , Adulto , Anciano , Anciano de 80 o más Años , Prótesis Dental de Soporte Implantado , Fracaso de la Restauración Dental , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Propiedades de Superficie , Adulto Joven
19.
J Craniofac Surg ; 25(6): e515-9, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25377979

RESUMEN

OBJECTIVES: This article proposes a simple preoperative score to evaluate the complexity of tooth extractions of the third mandibular molar and to estimate the time involved. STUDY DESIGN: We consider 11 factors (demographic, anatomic, and radiologic) that favor the surgery and that can be identified through standard clinical and radiologic examinations. The number of favorable factors (NFF) relative to each patient constitutes his/her score. The analysis of 1500 extractions performed by various surgeons with experience from 2 to 25 years evidences a quadratic inverse correlation between NFF and the time required for the surgery. RESULTS: The shape of the time distribution suggests the existence of 3 major classes of patients characterized by time of 4 to 10 minutes, 11 to 20 minutes, and 21 to 40 minutes. The corresponding NFF brackets, as identified by their frequency distributions and validated by the receiver operating characteristic curve method, are 5 to 11 (mean [SD], 6.8 [1.6]), 2 to 4 (3.3 [1.3]), and 0 to 1 (0.8 [1.0]), respectively. CONCLUSIONS: Our results show the good performance of this score as a predictor of the surgical time and its applicability in daily practice regardless of operator experience, background, and level of surgical ability.


Asunto(s)
Tercer Molar/cirugía , Tempo Operativo , Extracción Dental/clasificación , Extracción Dental/métodos , Diente Impactado/clasificación , Diente Impactado/cirugía , Adulto , Factores de Edad , Femenino , Humanos , Masculino , Mandíbula/cirugía , Diente Molar/cirugía , Puntaje de Propensión , Estudios Prospectivos , Reproducibilidad de los Resultados , Factores Sexuales
20.
J Craniofac Surg ; 25(6): 2081-3, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25304142

RESUMEN

BACKGROUND: The aim of this study was to compare the postoperative period and healing of 2 methods used for simple tooth extraction: traditional and ultrasonic bone surgery. The clinical healing of the sockets and psychologic acceptance of the ultrasonic bone surgery were also evaluated. METHODS: Two hundred patients requiring bilateral maxillary or mandibular extractions were enrolled. The extractions of the 2 teeth were performed in the same surgical session. The extraction on 1 side was performed using traditional surgery (control site), whereas ultrasonic surgery was used on the other side (test site). The patients were clinically screened at 1, 7, 14, and 21 days. RESULTS: A total of 200 patients (115 women and 85 men), with a mean age of 54.8 years (range, 40-65 y), provided 400 extraction sites. The time required to perform the tooth extractions was longer at the test site than at the control site, although this difference did not reach statistical significance. CONCLUSIONS: The piezoelectric extraction technique also provided the best surgical healing results, as evidenced by the integrity of the alveolar walls and surrounding soft tissues. In addition, the patients responded positively to ultrasonic surgery and preferred it to traditional surgery for both the surgical and postsurgical phases. CLINICAL IMPLICATION: Our preliminary study showed that Piezosurgery is an excellent tool for reducing the risk for complications and for improving the clinical healing and postoperative period in particular. The use of ultrasound reduces trauma to the adjacent bone and soft tissues during the tooth extraction.


Asunto(s)
Piezocirugía/métodos , Extracción Dental/métodos , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Complicaciones Intraoperatorias/prevención & control , Masculino , Mandíbula/cirugía , Maxilar/cirugía , Persona de Mediana Edad , Tempo Operativo , Dimensión del Dolor/métodos , Dolor Postoperatorio/etiología , Satisfacción del Paciente , Alveolo Dental/cirugía , Cicatrización de Heridas/fisiología
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