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1.
Braz. j. otorhinolaryngol. (Impr.) ; 83(2): 176-182, Mar.-Apr. 2017. tab
Artículo en Inglés | LILACS | ID: biblio-839430

RESUMEN

Abstract Introduction: Several studies have associated congenital sensorineural hearing loss in children with prolongation of the cardiac parameter QTc. The cause of this association is unknown. At the same time, mutations in GJB2, which encodes connexin 26, are the most common cause of congenital hearing impairment. Objective: To compare electrocardiographic parameters (PR interval, QRS complex, and QTc interval) in patients with hearing loss who were tested for mutations in GJB2 and GJB6 to investigate whether these mutations affect electrical activity of the heart. Methods: 346 patients (176 males, 170 females) with sensorineural hearing loss of 30 dB HL or more, aged 21.8 ± 19.9 years (including 147 children <14 years), underwent both genetic study for GJB2 and GJB6 mutations and electrocardiography. Results: Mutations in GJB2, including homozygotes and heterozygotes, were found in 112 (32%) patients. There were no significant differences in ECG parameters between groups of patients with and without mutations in GJB2. No differences were observed either in men (mean PR with mutation: 155 ± 16.6 vs. 153.6 ± 30.1 without; QRS: 99.9 ± 9.9 vs. 101.1 ± 15.4; QTc: 414.9 ± 29.9 vs. 412.4 ± 25.7) or women (mean PR with: 148.7 ± 21 vs. 143.8 ± 22.8 without; QRS: 94.8 ± 7.6 vs. 92.9 ± 9.6; QTc: 416.8 ± 20.6 vs. 424.9 ± 22.8). In similar fashion, we did we find any significant differences between groups of children with and without GJB2 mutations (mean PR with: 126.3 ± 19.6 vs. 127 ± 19.7 without; QRS: 80.7 ± 9.5 vs. 79.4 ± 11.6; QTc: 419.7 ± 23.5 vs. 419.8 ± 24.8). Conclusion: No association was found between the presence of GJB2 mutations encoding connexin 26 in patients with hearing loss and their ECG parameters (PR, QRS, QTc).


Resumo Introdução: Vários estudos têm associado a perda auditiva neurossensorial congênita em crianças ao prolongamento do parâmetro cardíaco QTc. A causa dessa associação é desconhecida. Ao mesmo tempo, as mutações no GJB2, que codifica a conexina 26, são a causa mais comum de deficiência auditiva congênita. Objetivo: Comparar parâmetros eletrocardiográficos (intervalo PR, complexos QRS e intervalo QTc) em pacientes com perda auditiva que foram testados para mutações no GJB2 e GJB6 para investigar se essas mutações afetam a atividade elétrica do coração. Método: Foram submetidos a estudo genético para mutações de GJB2 e GJB6 e eletrocardiograma 346 pacientes (176 homens, 170 mulheres) com perda auditiva neurossensorial de 30 dB ou mais, com média de 21,8 ± 19,9 anos (incluindo 147 crianças <14 anos). Resultados: Mutações no GJB2, inclusive homozigóticos e heterozigóticos, foram encontradas em 112 (32%) pacientes. Não houve diferenças significativas nos parâmetros de ECG entre grupos de pacientes com e sem mutações no GJB2. Não foram observadas diferenças em homens (PR médio com mutação: 155 ± 16,6 vs. 153,6 ± 30,1 sem mutação; QRS: 99,9 ± 9,9 vs. 101,1 ± 15,4; QTc: 414,9 ± 29,9 vs. 412,4 ± 25,7) nem em mulheres (PR médio com: 148,7 ± 21 vs. 143,8 ± 22,8, sem; QRS: 94,8 ± 7,6 vs. 92,9 ± 9,6; QTc: 416,8 ± 20,6 vs. 424,9 ± 22,8). Da mesma forma, encontramos diferenças significativas entre os grupos de crianças com e sem mutações de GJB2 (PR médio com: 126,3 ± 19,6 vs. 127 ± 19,7, sem; QRS: 80,7 ± 9,5 vs. 79,4 ± 11,6; QTc: 419,7 ± 23,5 vs. 419,8 ± 24,8). Conclusão: Não foi encontrada associação entre a presença de mutações de GJB2 que codificam conexina 26 em pacientes com perda auditiva e seus parâmetros de ECG (PR, QRS, QTc).


Asunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Adulto Joven , Síndrome de QT Prolongado/genética , Conexina 26/genética , Pérdida Auditiva Sensorineural/genética , Mutación , Síndrome de QT Prolongado/complicaciones , Electrocardiografía , Genotipo , Pérdida Auditiva Sensorineural/complicaciones
2.
Braz J Otorhinolaryngol ; 83(2): 176-182, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-27177978

RESUMEN

INTRODUCTION: Several studies have associated congenital sensorineural hearing loss in children with prolongation of the cardiac parameter QTc. The cause of this association is unknown. At the same time, mutations in GJB2, which encodes connexin 26, are the most common cause of congenital hearing impairment. OBJECTIVE: To compare electrocardiographic parameters (PR interval, QRS complex, and QTc interval) in patients with hearing loss who were tested for mutations in GJB2 and GJB6 to investigate whether these mutations affect electrical activity of the heart. METHODS: 346 patients (176 males, 170 females) with sensorineural hearing loss of 30dB HL or more, aged 21.8±19.9 years (including 147 children <14 years), underwent both genetic study for GJB2 and GJB6 mutations and electrocardiography. RESULTS: Mutations in GJB2, including homozygotes and heterozygotes, were found in 112 (32%) patients. There were no significant differences in ECG parameters between groups of patients with and without mutations in GJB2. No differences were observed either in men (mean PR with mutation: 155±16.6 vs. 153.6±30.1 without; QRS: 99.9±9.9 vs. 101.1±15.4; QTc: 414.9±29.9 vs. 412.4±25.7) or women (mean PR with: 148.7±21 vs. 143.8±22.8 without; QRS: 94.8±7.6 vs. 92.9±9.6; QTc: 416.8±20.6 vs. 424.9±22.8). In similar fashion, we did we find any significant differences between groups of children with and without GJB2 mutations (mean PR with: 126.3±19.6 vs. 127±19.7 without; QRS: 80.7±9.5 vs. 79.4±11.6; QTc: 419.7±23.5 vs. 419.8±24.8). CONCLUSION: No association was found between the presence of GJB2 mutations encoding connexin 26 in patients with hearing loss and their ECG parameters (PR, QRS, QTc).


Asunto(s)
Conexina 26/genética , Pérdida Auditiva Sensorineural/genética , Síndrome de QT Prolongado/genética , Mutación , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Electrocardiografía , Femenino , Genotipo , Pérdida Auditiva Sensorineural/complicaciones , Humanos , Lactante , Recién Nacido , Síndrome de QT Prolongado/complicaciones , Masculino , Persona de Mediana Edad , Adulto Joven
3.
Cardiol J ; 23(1): 34-41, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26412604

RESUMEN

BACKGROUND: The aim of the study was to determine, whether electrocardiogram (ECG) screening could reduce the risk of sudden cardiac death in patients with hearing loss through the early diagnosis of Jervell and Lange-Nielsen syndrome and the introduction of the therapy. METHODS: One thousand and eighty patients with hearing loss (aged 21.8 ± 19.9 years) underwent ECG. Additionally, all subjects were asked to complete a 3-question survey. Those who met, at least, one of the high-risk criteria underwent further cardiac assessment and genetic testing. RESULTS: QTc assessment was possible in 1,027 patients. Mean QTc measured 422.8 ± 23.7 ms in 313 women, 414.9 ± 27.7 ms in 273 men and 421.1 ± 21.5 ms in 441 children (individuals younger than 14 years). Abnormal QTc was found in 13 (4.1%) women, 20 (7.3%) men, and 72 (16.3%) children. In the studied group, no recessive mutation of KNCQ1 or KCNE1 was found. In 6 patients, other mutations were found: in KCNQ1 (n = 1), in KCNH2 (n = 3) and in SCN5A (n = 1), which were pathogenic for long-QT-syndromes (LQTS), and 2 mutations of unknown clinical significance in SCN5A. Overall, out of these 6 patients LQTS was diagnosed in 3 asymptomatic patients, but with abnormal QTc and in 2 patients with normal QTc, but who were previously treated for epilepsy. CONCLUSIONS: Jervell and Lange-Nielsen syndrome is a very rare condition even in a population with hearing loss. In this population, the prevalence of prolonged QT interval is increased over the general population. Further investigations are necessary.


Asunto(s)
Electrocardiografía , Pruebas Genéticas , Pérdida Auditiva Sensorineural/diagnóstico , Sistema de Conducción Cardíaco/fisiopatología , Frecuencia Cardíaca , Síndrome de Jervell-Lange Nielsen/diagnóstico , Mutación , Potenciales de Acción , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Femenino , Marcadores Genéticos , Predisposición Genética a la Enfermedad , Pérdida Auditiva Sensorineural/genética , Pérdida Auditiva Sensorineural/fisiopatología , Pruebas Auditivas , Humanos , Lactante , Síndrome de Jervell-Lange Nielsen/genética , Síndrome de Jervell-Lange Nielsen/fisiopatología , Masculino , Persona de Mediana Edad , Fenotipo , Polonia , Valor Predictivo de las Pruebas , Estudios Prospectivos , Factores de Riesgo , Encuestas y Cuestionarios , Adulto Joven
4.
Hum Mutat ; 35(10): 1171-4, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25044830

RESUMEN

RAB40AL has been reported as the locus for Martin-Probst syndrome (MPS), an X-linked deafness-intellectual disability syndrome. The report was based on segregation of a missense change p.D59G with the disease in a single family and in vitro localization studies. We found the p.D59G variant by whole-exome sequencing in two patients; however, the diagnosis of MPS was excluded in both cases. Furthermore, screening of control DNA samples (n = 810) from a general Polish population, using allele-specific PCR and direct DNA sequencing for verification, identified p.D59G in 8/405 males and 12/405 females. High prevalence of the p.D59G variant (2.47%) is typical for a common genetic variation observed in asymptomatic individuals. Our data question the role of RAB40AL mutation as a disease-causing change and the involvement of RAB40AL in MPS. Considering an increasing use of next-generation sequencing in the clinical setting, our finding is of practical diagnostic importance.


Asunto(s)
Anomalías Múltiples/genética , Enfermedades Genéticas Ligadas al Cromosoma X/genética , Pérdida Auditiva Sensorineural/genética , Discapacidad Intelectual/genética , Proteínas Mitocondriales/genética , Mutación Missense , Proteínas ras/genética , Niño , Femenino , Pruebas Genéticas , Humanos , Recién Nacido , Masculino , Persona de Mediana Edad , Linaje , Fenotipo , Polonia , Análisis de Secuencia de ADN
5.
DNA Cell Biol ; 31(7): 1267-73, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22424391

RESUMEN

Hearing impairment (HI) is the most common sensory handicap. Congenital HI often has a genetic basis, whereas the etiology of nonsyndromic postlingual HI (npHI) usually remains unidentified. Our purpose was to test whether the MTHFR C677T (rs1801133) polymorphism affecting folate metabolism is associated with the occurrence or severity of npHI. We studied rs1801133 genotypes in 647 npHI patients (age <40, sudden sensorineural loss excluded, HI characterized as mean of better ear hearing thresholds for 0.5-8 kHz) and 3273 adult controls from the background population. Genotype distribution among patients and controls was similar, but among male cases (n = 302) we found a dose-dependent correlation of MTHFR 677T with the degree of HI (mean thresholds in dB: 38.8, 44.9, and 53.3, for CC, CT, and TT genotypes, respectively; p = 0.0013, p(cor.) = 0.017). Among male patients rs1801133 TT significantly increased the risk of severe/profound HI (odds ratio = 4.88, p = 0.001). Among controls the known effect of MTHFR 677T on plasma total homocysteine was more pronounced in men than in women (p<0.00004 for genotype-sex interaction) suggesting that in Poland folate deficiency is more prevalent in males. In conclusion, we report a novel strong effect of MTHFR 677T among males with npHI. The functional significance of rs1801133 suggests that these patients may benefit from folate supplementation-an intervention which is simple, cheap, and devoid of side effects.


Asunto(s)
Pérdida Auditiva Sensorineural/enzimología , Pérdida Auditiva Sensorineural/genética , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Polimorfismo de Nucleótido Simple , Población Blanca/genética , Adulto , Anciano , Umbral Auditivo , Estudios de Casos y Controles , Cistamina/análogos & derivados , Cistamina/sangre , Femenino , Genotipo , Pérdida Auditiva Sensorineural/sangre , Pérdida Auditiva Sensorineural/psicología , Humanos , Masculino , Persona de Mediana Edad , Polonia , Adulto Joven
6.
Mol Genet Metab ; 104(1-2): 153-9, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21621438

RESUMEN

Mutations in mitochondrial DNA have been implicated in both, non-syndromic and aminoglycoside-induced hearing loss. In the present study, we have performed the systematic mutation screening of the COI/tRNA(Ser(UCN)) genes in 250 unrelated Polish subjects with hearing impairment. Three different homoplasmic sequence variants were identified, including one common polymorphism m.7476 C>T in tRNA(Ser(UCN)) and two mutations, m.7444 G>A and m.7445 A>G localized in the COI/precursor of tRNA(Ser(UCN)). The incidence of m.7444 G>A substitution was estimated at 1.6% (4/250), however variable penetrance of hearing loss, age of onset and hearing thresholds among m.7444 G>A carriers was observed. Two subjects had the positive history of aminoglycoside exposure and one of them harbored both m.7444 G>A and 12S rRNA m.1555 A>G mutations. Those suggest that m.7444 G>A itself is not sufficient to produce a clinical phenotype and additional modifier factors are required for pathogenic manifestation of m.7444 G>A substitution. Moreover, we have described the first Polish family with non-syndromic hearing loss, harboring m.7445 A>G mutation. The penetrance of hearing loss in this pedigree was 58% when aminoglycoside-induced hearing impairment was included, and 8% when ototoxic effect was excluded. This finding strongly suggests the possible role of m.7445 A>G in susceptibility to aminoglycoside induced-hearing loss.


Asunto(s)
Aminoglicósidos/efectos adversos , Complejo IV de Transporte de Electrones/genética , Pérdida Auditiva Sensorineural/inducido químicamente , Pérdida Auditiva Sensorineural/genética , Mitocondrias/enzimología , Mutación/genética , ARN de Transferencia de Serina/genética , Audiometría , Secuencia de Bases , Niño , Preescolar , Análisis Mutacional de ADN , ADN Mitocondrial/genética , Femenino , Humanos , Lactante , Masculino , Mitocondrias/genética , Datos de Secuencia Molecular , Linaje , Polonia
7.
Przegl Lek ; 68(1): 54-8, 2011.
Artículo en Polaco | MEDLINE | ID: mdl-21563446

RESUMEN

UNLABELLED: The aim was to identify the frequency of different causes of congenital hearing loss and to investigate the age of treatment intervention. MATERIAL: 197 children with hearing loss, hospitalized in the Department of Infant Diseases between 2007-2009. METHODS: Three-level audiological examinations, clinical investigations, specific tests for selected congenital infections and GJB2 mutations, neuroimaging. RESULTS: In 14 children with negative screening test hearing loss was confirmed; in 14 with positive was excluded; in 5 newborns screening test was not performed. In 179/197 the confirmation of hearing impairment was obtained up to 6 months (90%). Sensorineural (176/197), bilateral (157/197) hearing loss dominated; conductive and mixed was in 21/197. In 97/176 children with sensorineural hearing loss, congenital CMV infection was confirmed; in 47/176 - GJB2 mutations; in 21 simultaneous CMV infection and GJB2 mutation; in 26 the reason was not identified. The hearing aids were applied in 128, in 76 up to 6 months; the cochlear implants received 36, mainly in the 1st. and 2nd. year of life. The improvement of hearing was obtained in 33. CONCLUSIONS: 1. Early identification of infants with hearing loss allows for an earlier introducing of comprehensive treatment and improvement of hearing. 2. The significant proportion of children with hearing loss in the course of congenital cytomegalovirus infection indicates the need to carry out tests to identify infection in newborns with abnormal hearing screening test. 3. Cochlear implants are now in Poland the standard method of treatment in partial and complete deafness in children, also the youngest.


Asunto(s)
Pérdida Auditiva/congénito , Pérdida Auditiva/terapia , Audiología , Causalidad , Niño , Preescolar , Comorbilidad , Conexina 26 , Conexinas/genética , Infecciones por Citomegalovirus/epidemiología , Femenino , Pérdida Auditiva/diagnóstico , Pérdida Auditiva/epidemiología , Pérdida Auditiva/genética , Departamentos de Hospitales/estadística & datos numéricos , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Tamizaje Neonatal , Pediatría/estadística & datos numéricos , Polonia/epidemiología
8.
Biochem Biophys Res Commun ; 395(1): 116-21, 2010 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-20353758

RESUMEN

Mutations in mitochondrial DNA have been reported as associated with non-syndromic and aminoglycoside-induced hearing loss. In the present study, we have performed mutational screening of entire 12S rRNA gene in 250 unrelated patients with non-syndromic and aminoglycoside-induced hearing loss. Twenty-one different homoplasmic sequence variants were identified, including eight common polymorphisms, one deafness-associated mutation m.1555 A>G and three putatively pathogenic variants: m.669 T>C, m.827 A>G, m.961 delT+C(n)ins. The incidence of m.1555 A>G was estimated for 3.6% (9/250); however, where aminoglycoside exposure was taken as a risk factor, the frequency was 5.5% (7/128). Substitution m.669 T>C was identified only in patients with hearing impairment and episode of aminoglycoside exposure, which may suggest that such additional risk factors must appear to induce clinical phenotype. Moreover, two 12S rRNA sequence variants: m.988 G>A and m.1453 A>G, localized at conserved sites and affected RNA secondary structure, may be new candidates for non-syndromic and aminoglycoside-induced hearing loss associated mutations.


Asunto(s)
Aminoglicósidos/efectos adversos , Antibacterianos/efectos adversos , Genes Mitocondriales , Pérdida Auditiva/inducido químicamente , Pérdida Auditiva/genética , ARN Ribosómico/genética , Adolescente , Adulto , Niño , Preescolar , Análisis Mutacional de ADN , Femenino , Pruebas Genéticas , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Linaje , Polonia , Polimorfismo Genético , Población Blanca , Adulto Joven
9.
Eur J Hum Genet ; 17(4): 517-24, 2009 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18985073

RESUMEN

Hereditary hearing loss (HL) is a very heterogeneous trait, with 46 gene identifications for non-syndromic HL. Mutations in GJB2 cause up to half of all cases of severe-to-profound congenital autosomal recessive non-syndromic HL, with 35delG being the most frequent mutation in Caucasians. Although a genotype-phenotype correlation has been established for most GJB2 genotypes, the HL of 35delG homozygous patients is mild to profound. We hypothesise that this phenotypic variability is at least partly caused by the influence of modifier genes. By performing a whole-genome association (WGA) study on 35delG homozygotes, we sought to identify modifier genes. The association study was performed by comparing the genotypes of mild/moderate cases and profound cases. The first analysis included a pooling-based WGA study of a first set of 255 samples by using both the Illumina 550K and Affymetrix 500K chips. This analysis resulted in a ranking of all analysed single-nucleotide polymorphisms (SNPs) according to their P-values. The top 250 most significantly associated SNPs were genotyped individually in the same sample set. All 192 SNPs that still had significant P-values were genotyped in a second independent set of 297 samples for replication. The significant P-values were replicated in nine SNPs, with combined P-values between 3 x 10(-3) and 1 x 10(-4). This study suggests that the phenotypic variability in 35delG homozygous patients cannot be explained by the effect of one major modifier gene. Significantly associated SNPs may reflect a small modifying effect on the phenotype. Increasing the power of the study will be of greatest importance to confirm these results.


Asunto(s)
Conexinas/genética , Homocigoto , Mutación , Fenotipo , Conexina 26 , Variación Genética , Estudio de Asociación del Genoma Completo , Pérdida Auditiva/genética , Humanos , Polimorfismo de Nucleótido Simple
10.
Am J Med Genet A ; 143A(21): 2534-43, 2007 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-17935238

RESUMEN

Despite research the role of the M34T and V37I variants of GJB2 in causing hearing impairment (HI) remains controversial. Our purpose was to test a hypothesis that M34T and V37I are pathogenic but have distinct features resulting in a reduced penetrance. We screened for known GJB2/GJB6 mutations 233 Polish consecutive unrelated subjects with non-syndromic, sensorineural HI who were previously found to carry 35delG mutation on one chromosome. The most frequent mutations were also analyzed in approximately 1,000 controls. We found that M34T and V37I were significantly (P << 10(-6)) overrepresented among patients, but their penetrance was estimated as 1/10 relative to mutations of undisputed pathogenicity. This finding apparently could not be explained by low degree of HI associated with M34T and V37I since another mutation causing comparably mild HI (L90P) did not have reduced penetrance. Subsequent analyses showed that the patients with M34T/35delG and V37I/35delG had significantly later onset of HI than patients with other genotypes (P < 10(-6)) including the L90P/35delG (P = 0.006). Also, among these patients (but not others) a strong correlation between the degree of HI and its duration was found (r = 0.79, P < 10(-5)). We tentatively suggest that M34T and V37I might cause mild HI characterized by relatively late onset and progression.


Asunto(s)
Conexinas/genética , Pérdida Auditiva/genética , Mutación/genética , Adulto , Edad de Inicio , Estudios de Casos y Controles , Estudios de Cohortes , Conexina 26 , ADN/análisis , ADN/genética , Progresión de la Enfermedad , Femenino , Genotipo , Pérdida Auditiva/patología , Humanos , Masculino , Persona de Mediana Edad , Penetrancia , Reacción en Cadena de la Polimerasa , Polimorfismo de Longitud del Fragmento de Restricción
11.
Am J Hum Genet ; 77(6): 945-57, 2005 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16380907

RESUMEN

Hearing impairment (HI) affects 1 in 650 newborns, which makes it the most common congenital sensory impairment. Despite extraordinary genetic heterogeneity, mutations in one gene, GJB2, which encodes the connexin 26 protein and is involved in inner ear homeostasis, are found in up to 50% of patients with autosomal recessive nonsyndromic hearing loss. Because of the high frequency of GJB2 mutations, mutation analysis of this gene is widely available as a diagnostic test. In this study, we assessed the association between genotype and degree of hearing loss in persons with HI and biallelic GJB2 mutations. We performed cross-sectional analyses of GJB2 genotype and audiometric data from 1,531 persons, from 16 different countries, with autosomal recessive, mild-to-profound nonsyndromic HI. The median age of all participants was 8 years; 90% of persons were within the age range of 0-26 years. Of the 83 different mutations identified, 47 were classified as nontruncating, and 36 as truncating. A total of 153 different genotypes were found, of which 56 were homozygous truncating (T/T), 30 were homozygous nontruncating (NT/NT), and 67 were compound heterozygous truncating/nontruncating (T/NT). The degree of HI associated with biallelic truncating mutations was significantly more severe than the HI associated with biallelic nontruncating mutations (P<.0001). The HI of 48 different genotypes was less severe than that of 35delG homozygotes. Several common mutations (M34T, V37I, and L90P) were associated with mild-to-moderate HI (median 25-40 dB). Two genotypes--35delG/R143W (median 105 dB) and 35delG/dela(GJB6-D13S1830) (median 108 dB)--had significantly more-severe HI than that of 35delG homozygotes.


Asunto(s)
Conexinas/genética , Pérdida Auditiva/genética , Pérdida Auditiva/fisiopatología , Estudios Multicéntricos como Asunto , Mutación , Adolescente , Adulto , Anciano , Alelos , Audiometría , Niño , Preescolar , Conexina 26 , Estudios Transversales , Análisis Mutacional de ADN , Femenino , Frecuencia de los Genes , Genes Recesivos , Heterocigoto , Homocigoto , Humanos , Lactante , Recién Nacido , Modelos Lineales , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Índice de Severidad de la Enfermedad
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