[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].

The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment. In total, 6603 (19%) adverse-effects were recorded. Their severity was evaluated as mild in 84,48%, no serious adverse-effects were noted. The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated. The high level of tolerability and absence of the clinically significant increase of adverse effects in the combination with nonsteroidal anti-inflammatory drugs have been confirmed.

[The clinico-morphological characteristics of synovial membrane involvement in beta-thalassemia]. / Kliniko-morfologicheskaia kharakteristika porazheniia sinovial'noi obolochki pri beta-talassemii.

Using data on optic and electron microscopy the authors give characteristics of lesions in the synovial membrane of the knee joints in 6 patients with an intermediary form of beta-thalassemia. Multiple reduplication of the basal membrane was noted in all the vessels, the width of the noncellular component of the vessels increased several times and its stratification was clearly seen. Deposits of iron oxide were revealed in biopsy samples of the synovial membrane of all the patients. Those deposits were in the form of microgranular intracellular inclusions in phagocytosing cells of the superficial stroma of villi but more often they were found in the cytoplasm of the vessel cells and pericytes.

[Osteoarthropathy in beta-thalassemia]. / Osteoartropatiia pri beta-talassemii.

A total of 45 patients with beta-thalassemia and 30 patients with thalassemia intermedia underwent clinical and x-ray examinations. Electron microscopy was used to examine biopsy specimens of the synovial membrane from 6 patients with homozygous thalassemia intermedia. It has been revealed that damage to the osseous system and joints is of systemic nature and depends on the clinical form of the pathological process. Morphological methods have demonstrated abnormal metabolism of iron with its deposition in the tissues and impairment of the vessels of the microcirculatory bed.

[The echocardiographic characteristics of cardiac lesions in beta-thalassemia]. / Ekhokardiograficheskaia kharakteristika porazheniia serdtsa pri beta-talassemii.

The authors submit the results of clinicoechocardiographic investigations of 35 patients with beta-thalassemia aged from 4 to 37 years of whom 23 patients were with acute beta-thalassemia, 6 with an intermediary form and 6 with a heterozygotic form of the disease. Various echocardiographic changes were observed in patients with acute and intermediary forms of beta-thalassemia, i.e. prolapse of the mitral valve (52 and 50 per cent), the presence of fluid in the pericardium (13 and 17 per cent), structural changes in the valvular apparatus (56 and 83 per cent), disorders of the inotropic and diastolic functions of the heart.