Recent trends in anti-obesity and anti-inflammatory studies in modern health care.

BACKGROUND: This study was planned to investigate the research trends related to naturally derived anti-inflammatory and anti-obesity components. The main purpose of this study was to find out and develop natural health cosmetic ingredients which has high effects on lipid degradation, moisturizing and elasticity enhancement. OBJECTIVE: We all hope this research provided systematic and practical data that can suggest an opportunity to further develop new products. METHODS: This is a descriptive research which classified the natural and traditional components that have important obesity management effects based on the experimental technique (in vitro and in vivo). we investigated the effects of 13 natural raw materials selected through preliminary investigation on lipid metabolism related enzyme activity. We first introduced Ainsliaea acerifolea, Onion, pear, Sanguisorba, Limonium tetragonum, Cornus walteri, Loquat, and Loquat-which have recently been shown to be effective in anti-obesity tests, and then described the research methods by showing the effects of onion extracts, Glasswort, Pine Cone (Korean white pine), Orostachys japonicus, African mangoes, Pepper, and Clathratum (sea weed), which actually had effects on anti-obesity in the in vivo experiment. RESULTS: As a result of investigating the effect of 13 natural raw materials selected through a preliminary investigation on lipid metabolism related enzyme activity, the study found nature-derived ingredients which induce anti-inflammatory and enhance the anti-obesity enzyme activity, and ingredients showing myriads of biological activities such as anti-oxidant, body fat reduction, lowering of blood cholesterol, and weight control. CONCLUSION: In this paper, we would like to delve into the possibility of using natural components with natural lipid-lowering effect, and systematically and practically study if they can actually be helpful to develop new cosmetic products.

Effects of bilateral vasectomy on the interleukin 1 system in mouse epididymis.

PROBLEM: Regional difference in the inflammatory response in vasectomized (VAX) epididymis remains unraveled. METHOD OF STUDY: Epididymal expression of interleukin 1α (IL1α), IL1ß, IL1 receptor antagonist (IL1ra), IL1 receptor 1 (IL1R1), IL6, IL10, tumor necrosis factor α (TNF-α), and transforming growth factor-ß1 (TGF-ß1) was examined in bilateral VAX mice by real-time RT-PCR and immunohistochemistry. RESULTS: IL1α, IL1ß, IL1ra, and IL1R1 were expressed in the epididymal epithelia of normal mice. Following VAX, IL1R1 mRNA was not changed, but TNF-α, IL10, IL1α, IL1ß, and IL1ra mRNA were significantly upregulated in whole epididymis, whereas IL6 and TGF-ß1 mRNA were significantly increased in corpus and cauda but not in caput epididymis. Consistently, IL1α, IL1ß, and IL1ra immunoreactivities were visibly increased in epididymis following VAX. CONCLUSION: Following VAX, IL1α, IL1ß, IL1ra, IL10, and TNF-α may mediate immune reaction in whole epididymis, whereas IL6 and TGF-ß1 may mediate regionally different immune response primarily in the lower part of epididymis.