Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 60
Filtrar
1.
J Hand Microsurg ; 16(1): 100005, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38854365

RESUMEN

Background: Complex proximal interphalangeal joint (PIPJ) fractures are challenging injuries to treat. There are multiple established treatment methods available for these injuries, including dynamic external fixation. This study reports the outcomes of complex PIPJ fractures treated with a hand-specific external fixation device. Methods: Twenty-five fingers in 25 patients were treated with the DigiFix external fixator device for treatment of a PIPJ dorsal fracture dislocation (n = 16) or pilon fracture (n = 9). There were 16 males and 9 females with a mean age of 40 years (range: 14-75 years) at the time of injury. The median time from injury to surgery was 10 days (interquartile range [IQR]: 5; range: 3-49). Chart and radiographic data were reviewed retrospectively. Results: The average duration of external fixation was 41 days (range: 26-62 days). At a mean follow-up of 28 weeks (range: 12-105 weeks), the mean PIPJ flexion was 82 (range: 30-105 degrees), extension was -10° (range: -30 to 0 degrees), and flexion/extension arc of motion was 72 degrees (range: 30-95 degrees). Final mean Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score was 21.5 (range: 0-65.8). There were zero major complications and six (24%) minor complications, including superficial cellulitis (4) and stiffness (2). Conclusion: Dynamic external fixation for the treatment of complex PIPJ injuries allows for early range of motion and leads to favorable outcomes. This hand-specific external fixator has a reproducible technique which results in predictable and reliable PIPJ distraction.

2.
Foot Ankle Int ; 44(9): 913-921, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-37329183

RESUMEN

BACKGROUND: Open repair of Achilles tendon ruptures is associated with a risk of infection and other wound complications. Although percutaneous repairs reduce these complications, they may increase the risk of nerve injury. This study was designed to determine whether a percutaneous nonlocking repair can approach the gapping resistance offered by a standard open repair under conditions approximating typical postoperative physiotherapy. METHODS: Ten pairs of cadavers Achilles tendons were transected in situ 5 cm above the insertion. One tendon from each pair was repaired using an open 4-strand Krackow locking loop, and the contralateral tendon was repaired with the Achillon system using the same suture material. Displacement transducers were attached to the medial, lateral, anterior, and posterior aspects of the tendon, spanning the repair. Each tendon underwent 1000 tensile loading cycles to 86.5 N, simulating passive ankle range-of-motion physiotherapy. Gapping was documented on the 1st, 50th, 100th, 500th, and 1000th cycles. The ultimate tensile strength of each repaired tendon was then measured by distracting until gross failure occurred. RESULTS: Gapping of the percutaneous repairs exceeded that of conventional open repairs on the first, 500th, and 1000th load cycles. All 10 conventionally repaired tendons withstood 1000 load cycles without gross failure, but 4 of 10 percutaneous minimally invasive repairs failed, one on the 9th load cycle and the others between the 100th and 500th cycles. On average, tendons repaired with the open technique withstood 66% greater tensile load in failure testing than those repaired with the percutaneous technique. CONCLUSION: Open Krackow Achilles tendon repairs may better withstand more aggressive postoperative physiotherapy than nonlocked percutaneous repairs. CLINICAL RELEVANCE: The study suggests that surgeons should consider locking suture approaches to avoid loss of repair integrity with early motion.


Asunto(s)
Tendón Calcáneo , Traumatismos de los Tendones , Humanos , Tendón Calcáneo/lesiones , Técnicas de Sutura , Traumatismos de los Tendones/cirugía , Rotura/cirugía , Resistencia a la Tracción , Fenómenos Biomecánicos
3.
Foot Ankle Spec ; : 19386400231174814, 2023 May 26.
Artículo en Inglés | MEDLINE | ID: mdl-37243379

RESUMEN

Hallux valgus is a common progressive forefoot deformity. Although open techniques have shown good outcomes, no technique has been shown to be superior to other techniques. The current third generation of minimally invasive Chevron-Akin (MICA) technique features a percutaneous procedure with a stable internal fixation. The technique used in this study resulted in stable internal fixation; however, 1 screw was used in intramedullary fashion in the majority of cases. The purpose of this study is to review the early outcomes of MICA. Electronic Health Records (EHR) were queried for patients who underwent MICA to treat hallux valgus (HV) deformity, by a single surgeon. The primary clinical outcomes assessed were visual analog pain score (VAS), rate of revision surgery, and recurrence. Radiographic outcomes were assessed including pre and postoperative hallux valgus angle (HVA), intermetatarsal angle (IMA), and bony foot width. The secondary outcomes included postoperative complications. A total of 91 feet underwent MICA to correct symptomatic HV deformity. The mean age of this cohort was 53.63 ± 15.42 years, mean body mass index (BMI) of 26.81 ± 6.21 kg/m2, mean follow-up of 6.33 ± 6.39 months and 87 feet belonged to female patients. Patients showed significant improvement in VAS and radiographic outcomes at final follow-up, with a mean improvement of 10.70° ± 6.42°, 2.39° ± 3.55°, and 5.30 mm ± 4.23 mm for the HVA, IMA, and bony foot width, respectively. Two patients (2.2%) required revision surgery for nonunion and removal of symptomatic hardware. One patient had a second metatarsal fracture treated nonoperatively. No feet had recurrence, hardware loosening, infection, or scar hypersensitivity. The current study reported on early outcomes for MICA. This technique appears to be effective and safe with no failure of fixation in our patients. We showed in our short-term follow-up, MICA led to significant improvement in pain and radiographic scores.Levels of Evidence: III, retrospective study.

4.
Foot Ankle Spec ; : 19386400221147773, 2023 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-36727310

RESUMEN

BACKGROUND: While metatarsophalangeal joint (MTPJ) arthrodesis is regarded as the gold standard treatment option for end-stage hallux rigidus (HR), synthetic cartilage implant (SCI) resurfacing has gained popularity. This study aimed to identify the SCI resurfacing failure rate for a single surgeon, while also comparing clinical outcomes of patients who underwent SCI replacement or MTPJ arthrodesis after failed index SCI resurfacing. METHODS: Health records were queried from 2016 to 2021 for patients with HR who were treated with SCI resurfacing by a single surgeon. Preoperative and postoperative range of motion, visual analog scale (VAS) pain scores, and hallux valgus angles were compared. A subgroup analysis was performed on patients who underwent revision with SCI replacement or MTPJ arthrodesis. SCI replacement included the use of bone graft, bone putty, or a custom 3D printed baseplate to prevent implant subsidence. RESULTS: A total of 219 SCI resurfacing procedures were performed by a single surgeon, including 23 revisions. When analyzing index procedures, an 8.2% revision rate was determined. The revision cohort (n = 23) consisted of 19 female patients and presented with a mean body mass index of 29.5 ± 5 kg/m2, mean age of 52.8 ± 11 years, mean follow-up duration of 22.3 (range, 3-54) months, and mean time to a revision surgery of 12.1 ± 12 (range, 1-50) months. Specifically, 12 procedures resulted in an SCI replacement, while 11 procedures resulted in arthrodesis. While all patients experienced significant improvement in their VAS pain scores (P < .001), the arthrodesis cohort experienced a greater improvement than the SCI revision cohort (P = .04). CONCLUSION: When analyzing SCI revision procedures, MTPJ arthrodesis reduced pain more significantly than SCI replacement. LEVELS OF EVIDENCE: Level IV: Retrospective case series.

5.
J Foot Ankle Surg ; 62(1): 115-119, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-35697653

RESUMEN

The increase in artificial turf in the 1970s was thought to have contributed to increased incidence of turf toe injury in National Football League (NFL) players. To our knowledge, there are no publications that have analyzed the impact of this injury on performance. This is a retrospective case series. Online resources were used to identify NFL players who sustained a turf toe injury between the 2011 and 2014 seasons. The performance of each offensive skill player was analyzed separately by calculating their power rating (PR) over 6 seasons. Injured offensive skill players were then compared to a control group consisting of all RBs and WRs without a turf toe injury who competed in the 2012 season. Seventy-one turf toe injuries were identified. Twenty-nine occurred on grass, 29 on turf and the playing surface of 13 injuries could not be identified. The average PR prior to injury was 105.7/season (7.3/game), 87.3 (6.9/game) for the season of injury and 115.5 (8.1/ game) for postinjury seasons. The PR was not significantly different after a turf toe injury compared to before injury or to uninjured control player. There was no significant difference in NFL players' performances after turf toe injury based on power ratings.


Asunto(s)
Traumatismos en Atletas , Traumatismos de los Pies , Fútbol Americano , Fútbol , Humanos , Fútbol Americano/lesiones , Estudios Retrospectivos , Traumatismos en Atletas/epidemiología , Fútbol/lesiones , Traumatismos de los Pies/etiología , Traumatismos de los Pies/complicaciones
6.
Foot Ankle Spec ; 16(3): 273-282, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36039497

RESUMEN

Late-stage talar avascular necrosis (AVN) results in devascularization of the talus with osteonecrosis and subchondral collapse. A combined total ankle and total talus replacement (TATTR) with hindfoot arthrodesis may be utilized for end-stage talar AVN with tibiotalar and hindfoot joint arthritis. The purpose of this study is to evaluate the short-term outcomes of combined TATTR with hindfoot arthrodesis. Patients who underwent a combined TATTR or TTR with a hindfoot arthrodesis (subtalar with or without talonavicular arthrodesis) from 2016 to 2020 were retrospectively reviewed. Patient demographics, comorbidities, and surgical data were collected. Outcomes included the Visual Analog Scale (VAS) scores, range of motion, radiographic parameters, union rates, and complications. A total of 18 patients were reviewed. Nine patients were included with an average of 19.4 months follow-up. Significant postoperative improvements were observed in VAS scores (P < .001), ankle plantarflexion (P = .04), talocalcaneal height (P = .03), and tibiotalar alignment (P = .02). All patients achieved a successful union of their subtalar and talonavicular joints arthrodesis. There was one reoperation for a persistent varus ankle deformity. This is the first study to evaluate the clinical outcomes, radiographic outcomes, and union rate in combined TATTR with hindfoot arthrodesis. The early results demonstrated significant clinical improvement with 100% hindfoot union rate and no prosthetic failure.Level of Evidence: IV.


Asunto(s)
Osteonecrosis , Astrágalo , Humanos , Astrágalo/diagnóstico por imagen , Astrágalo/cirugía , Tobillo , Estudios Retrospectivos , Articulación del Tobillo/diagnóstico por imagen , Articulación del Tobillo/cirugía , Artrodesis/métodos , Osteonecrosis/diagnóstico por imagen , Osteonecrosis/cirugía , Impresión Tridimensional , Resultado del Tratamiento
7.
Foot Ankle Spec ; : 19386400221138640, 2022 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-36482676

RESUMEN

INTRODUCTION: Avascular necrosis (AVN) of the talus is 1 of the most difficult foot and ankle pathologies to diagnose and manage. The purpose of this study was to report on the functional outcomes of 3D-printed total talus replacement (TTR) in 2 patients with talar AVN who both underwent a failed revascularization. METHODS: This is a case series of 2 patients with TTR after a failed revascularization and a comparison group of 25 patients with primary TTR. Clinical and functional outcomes are used to compare both groups. RESULTS: Patient 1 had a postrevascularization Visual Analogue Scale (VAS) pain score of 9. Imaging showed failure of the medial femoral condyle to incorporate with talar fragmentation. Patient underwent TTR at 5 months postoperatively. At 2 years postoperatively, the patient underwent a cavovarus foot reconstruction; however, patient continued to suffer from ankle pain (VAS 6) and ultimately underwent below knee amputation at 3 years after the TTR. Patient 2 initially underwent a core decompression for a talar bone infarct followed by revascularization procedure at 6 months postoperatively due to persistent pain and bony infarcts. At 18 months postrevascularization, the patient had a VAS pain score of 9 and progression of the AVN. She underwent a TTR. At 1-year follow-up, the VAS pain score was 8. Both patients had an ankle plantarflexion of 30° at their last TTR follow-up. The comparison group consisted of 25 patients who underwent 3D-printed TTR with mean postoperative VAS score and ankle plantarflexion of 3.7° and 41.8°. CONCLUSION: Patients 1 and 2 demonstrated reduced plantarflexion and ankle motion after TTR relative to the comparison group which improved in both physical assessments. The first patient needed a below knee amputation for persistent pain. Patient 2 showed less improvement in all the foot and ankle outcome scores as compared with the primary TTR group. LEVEL OF EVIDENCE: Level V: Retrospective case series.

8.
Foot Ankle Clin ; 27(4): 805-818, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36368798

RESUMEN

A flatfoot deformity is a multiplanar foot deformity characterized by forefoot abduction and supination and hindfoot valgus. With progressive pathology, a rigid deformity may develop. In the setting of a rigid deformity, the appropriate procedure to use is not without controversy. The extent of joints to involve in the arthrodesis depends on the ability to obtain a plantigrade foot. Both double and triple arthrodesis have been suggested. Care must be taken to avoid lateral column shortening and loss of foot reduction when fusing the CC joint. The concerns about lateral skin breakdown led some surgeons to describe a single medial incision for a triple or modified double arthrodesis. The necessity of bone grafting has been controversial. Implant selection is essential to achieve solid stabilization of the arthrodesis sites. To decrease the risk of overcorrection and malunion, the surgeon should be familiar with the hindfoot biomechanics and generate, based on the clinical examination and imaging, a meticulous preoperative plan to address and balance both the soft tissue and bony deformity.


Asunto(s)
Pie Plano , Deformidades del Pie , Coalición Tarsiana , Articulaciones Tarsianas , Humanos , Pie Plano/diagnóstico por imagen , Pie Plano/cirugía , Artrodesis/métodos , Pie , Articulaciones Tarsianas/cirugía
9.
Foot Ankle Spec ; : 19386400221088455, 2022 Apr 19.
Artículo en Inglés | MEDLINE | ID: mdl-35440185

RESUMEN

Different procedures have been reported for severe and recurrent lesser toes deformity. These included DuVries metatarsophalangeal joint arthroplasty, resection arthroplasty, partial proximal phalangectomy, syndactylization, or lesser toe amputation. In the presence of a failed metatarsal head resection, the surgeon is faced with limited salvage options including Hoffman procedure or lesser toe amputation. The 3D printing technology has allowed orthopaedic surgeons to expand the therapeutic arsenal to address challenging situations. We herein present the first case of 3D-printed second lesser metatarsal replacement performed after a failed second metatarsal head resection.Level of Evidence: V.

10.
Sportverletz Sportschaden ; 36(1): 55-59, 2022 03.
Artículo en Inglés | MEDLINE | ID: mdl-32663898

RESUMEN

BACKGROUND: The deltoid is a large triangular muscle at the shoulder. It attaches proximally to the clavicle, acromion and scapula, while distally it attaches to the lateral deltoid tuberosity. Ruptures are rare, and the literature only reports cases of proximal detachment. In this article, we report the first case of distal traumatic deltoid muscle detachment and its successful management. CASE: A young female sustained a traumatic injury following a Jet Ski accident with loss of consciousness. A complete distal rupture of the deltoid muscle was diagnosed after the basic functions were regained and a thorough musculoskeletal examination could be conducted. A conservative approach helped her to regain an acceptable shoulder function, but there was persistent pain upon activity and cosmetic scarring. The patient underwent surgical reconstruction. Postoperatively, she recovered satisfactorily. DISCUSSION: Distal detachment of the deltoid muscle is rare. The choice for surgical treatment may be undertaken based on several factors including functional status and patient-based assessment.


Asunto(s)
Músculo Deltoides , Hombro , Músculo Deltoides/cirugía , Femenino , Humanos , Rotura
11.
J Foot Ankle Surg ; 60(1): 163-166, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33162292

RESUMEN

Giant cell tumor of the tendon sheath is a slowly growing benign tumor. It usually arises from the tendon sheath and periarticular soft tissue of small joints. However, it may infrequently involve the large joints emerging around the knee, elbow, and hip joints. Giant cell tumor of the tibialis tendon sheath is rarely reported in the foot and ankle joint. Here, we report the first case in the medical literature of bilateral mirror-symmetrical giant cell tumor of the tendon sheath in the foot and ankle. A 12-year-old male presented with a bilateral and mirror-image mass on his ankles extending to the foot. It was painless but affected his gait and footwear. Staged complete resection was done first on the right then on the left side, with no recurrence after 1 year. The role of genes can be argued for this presentation and giant cell tumor's etiology, owing to the bilateralism and mirror-image presentation. Studies are needed to explore this genetic aspect and its role in management.


Asunto(s)
Tobillo , Tumores de Células Gigantes , Articulación del Tobillo/diagnóstico por imagen , Articulación del Tobillo/cirugía , Niño , Tumores de Células Gigantes/diagnóstico por imagen , Tumores de Células Gigantes/cirugía , Humanos , Masculino , Recurrencia Local de Neoplasia , Tendones/diagnóstico por imagen , Tendones/cirugía
12.
Med Princ Pract ; 30(3): 223-235, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33040057

RESUMEN

Low-carbohydrate ketogenic diet (LCKD), originally used as a treatment for childhood epilepsy is currently gaining acceptance as a nutritional therapy for obesity and type 2 diabetes. In addition, this diet has a positive effect on body weight, blood glucose level, glycosylated hemoglobin, plasma lipid profile, and neurological disorders. This review focuses on the therapeutic effectiveness, negative effects, and the rationale of using LCKD for the treatment of type 2 diabetes. It is shown that LCKD contributes to the reduction in the intake of insulin and oral antidiabetic drugs in patients with type 2 diabetes. Furthermore, the data presented in this review reveal the efficacy and cost-effectiveness of LCKD in the management of type 2 diabetes.


Asunto(s)
Diabetes Mellitus Tipo 2/dietoterapia , Dieta Cetogénica , Carbohidratos de la Dieta , Niño , Hemoglobina Glucada , Humanos
13.
J Biomech ; 103: 109683, 2020 04 16.
Artículo en Inglés | MEDLINE | ID: mdl-32200997

RESUMEN

National Biomechanics Day aims to introduce students to the emerging field of biomechanics and improve their perception of engineering and engineers. This quantitative study examines participants' attitude changes following one such event. By prioritizing increasing excitement and engagement over teaching content, we anticipate that students' opinions of engineering and biomechanics will improve following the event. Pre- and post-test surveys consisting of Likert scale and semantic differential (SD) items assessed changes in three key areas: self-identity as a scientist and engineer, attitudes toward engineering, and attitudes toward biomechanics. Based on unpaired and paired student responses, we found significant gains in all three areas. Students agreed more strongly with statements regarding whether they saw themselves as scientists and engineers, and they had improved attitudes toward engineering in general and biomechanics specifically. The SD scales also reflected improved opinions of both science and biomechanics. These more positive attitudes could eventually lead to more students recruited to study a variety of engineering disciplines, ultimately addressing the ongoing national shortage of qualified engineers.


Asunto(s)
Actitud , Instituciones Académicas , Fenómenos Biomecánicos , Ingeniería , Humanos , Encuestas y Cuestionarios
14.
J Pediatr Orthop B ; 29(5): 510-513, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31356507

RESUMEN

The surgical treatment of bone sarcoma involves wide surgical resection and endoprosthetic replacement. Surgical resection for proximal tibia bone sarcoma includes the patellar tendon. The secondary extension lag is a common complication and, although many have been described, the options for reconstruction of the patellar tendon are suboptimal. We propose adding a biological reinforcement, the hamstring tendons, to our extensor mechanism reconstruction technique (polyprolene mesh and gastrocnemius flap). We describe the surgical technique and, using an illustrative case, compare the outcome of this technique with the outcome following reconstruction without reinforcement. Level of evidence: Level III.


Asunto(s)
Neoplasias Óseas/cirugía , Tendones Isquiotibiales/trasplante , Osteosarcoma/cirugía , Rótula/cirugía , Mallas Quirúrgicas , Tibia , Neoplasias Óseas/diagnóstico por imagen , Estudios de Seguimiento , Humanos , Osteosarcoma/diagnóstico por imagen , Colgajos Quirúrgicos , Trasplante Autólogo , Resultado del Tratamiento
15.
Int J Legal Med ; 132(4): 1117-1124, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25773917

RESUMEN

Because acellular dental cementum is considered to be formed continually throughout life and to not undergo remodeling processes, cementochronology is considered to be a method with the potential for directly assessing chronological age. Considering that most previous studies on humans have assumed the superior performance of this method, it is surprising that this technique is not more widely adopted in anthropology. To understand this controversy, we highlight that there is no standardized procedure for sample preparation. The numerous technical approaches that exist impact the reliability of the method, and the recent creation of an international work group (Cementochronology Research Program) demonstrates the need for researchers to share their experience to overcome these obstacles. This paper aims to address this paradox by debating the aspects that contribute to the limited use of this method and by illustrating its potential through an application on forensic cases. A protocol, which was recently certified according to the ISO-9001, was applied to nine anthropological cases from the Forensic Medicine Institute of Lille (northern France) and compared with routine osteological and dental methods. The results show that traditional methods matched the known age due to the wide extent of their range, while the accuracy and precision of cementochronological estimates was also notable. This paper establishes that cementochronology may serve as a particularly important tool for age estimation for forensic anthropologists and should, at least, be used in addition to other methods.


Asunto(s)
Determinación de la Edad por los Dientes/métodos , Cemento Dental/patología , Determinación de la Edad por el Esqueleto , Anciano , Huesos/patología , Femenino , Antropología Forense , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Microscopía , Persona de Mediana Edad , Variaciones Dependientes del Observador , Fotomicrografía , Reproducibilidad de los Resultados
16.
Int J Paleopathol ; 15: 120-127, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-29539546

RESUMEN

Bioarchaeologists rely on accurate estimations of age-at-death. Clearly, some pathological conditions are associated with gross morphological changes in the skeleton that could impact the effectiveness of age-at-death estimation (i.e. methods based on the pelvis, fourth rib, dental attrition, and cranial stenosis). The magnitude of this problem has not been widely studied due to a paucity of pathological skeletons of known age. We assessed age-at death for three individuals affected by bone dysplasias (achondroplasia, residual rickets, osteogenesis imperfecta) using cementum annulations and several osseous age indicators. We predicted osseous indicators that are based on gross morphological changes would yield age estimates discrepant from the cementochronology. Results demonstrated considerable differences in age estimates between morphological and histological techniques suggesting a need for additional research on the effects of pathology on the accuracy of morphological methods. Conversely, we addressed the proposition that cementum annulations will be inappropriate for age estimation in cases of chronic and severe rhino-maxillary infection and periodontitis. We assessed age-at-death for one individual with leprosy and found no indication the disease process affected cementum formation or preservation. The results of this research indicate the potential value of cementochronology in cases where skeletal pathological conditions constrain the usefulness of traditional age estimation approaches.


Asunto(s)
Determinación de la Edad por los Dientes , Muerte , Cemento Dental , Atrición Dental , Técnicas Histológicas , Humanos , Paleontología
17.
J Hand Microsurg ; 7(1): 102-3, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26078513
18.
Int J Paleopathol ; 9: 8-14, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29539444

RESUMEN

Two individuals with bilateral Madelung's deformity were identified in a Late Intermediate period comingled tomb at the northern highland site of Marcajirca, Ancash, Peru (ca. AD 1250). Comparisons of the size and robusticity of the radii and ulnae suggest the individuals represent a male and a female. The difference in the severity of the changes is thought to represent variability in the expression of the deformity seen in males and females in clinical cases. Three comparatively short, thick tibiae were also recovered from this tomb, which may suggest that the individuals demonstrate Léri-Weill dyschondrosteosis, a type of dwarfism characterized by mesomelic shortening. These are the first examples of Madelung's deformity to be described from an archaeological context in South America and offer an insight into the use of tombs (chullpas) in Late Intermediate period Ancash.

19.
Hemoglobin ; 38(5): 351-4, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25271993

RESUMEN

The increase in survival rate of ß-thalassemia (ß-thal) patients allowed for the appearance and manifestation of several complications in almost every organ system. Priapism in ß-thal patients is rarely reported in the literature. We herein report and investigate the occurrence of two cases of priapism in two young patients with ß-thal intermedia (ß-TI). The potential mechanisms are due to either a cellular mechanism involving a thrombus obstructing the efferent venules of the corpora cavernosa leading to priapism, or a recently elucidated functional mechanism that causes alteration of nitric oxide (NO) response of the penis, ultimately causing priapism. This should incite clinicians for a close follow-up and monitoring of high risk patients who are susceptible to developing priapism.


Asunto(s)
Priapismo/etiología , Talasemia beta/fisiopatología , Antagonistas Adrenérgicos beta/uso terapéutico , Adulto , Terapia Combinada , Combinación de Medicamentos , Antagonistas de los Receptores Histamínicos H1/uso terapéutico , Humanos , Masculino , Priapismo/prevención & control , Propranolol/uso terapéutico , Seudoefedrina/uso terapéutico , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Triprolidina/uso terapéutico , Talasemia beta/tratamiento farmacológico , Talasemia beta/terapia
20.
Pediatr Hematol Oncol ; 31(7): 583-96, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25247665

RESUMEN

Beta-thalassemia intermedia (ß-TI) is a genetic variant of beta-thalassemias with a clinical disorder whose severity falls between thalassemia minor and thalassemia major. Different genetic defects are involved in this disorder and, based on severity of disease, clinical complications like skeletal deformities and growth retardation, splenomegaly, extramedullary hematopoiesis, heart failure, and endocrine disorders may be present in untreated patients. Precise diagnosis and management are essential in these patients for prevention of later clinical complications. Diagnosis of TI is based on clinical and laboratory data. There are some treatment strategies like modulation of gamma-globulin chain production with hydroxyurea or other drugs, transfusion, splenectomy, and stem cell transplantation. Iron chelation therapy is also needed in many of these patients even if they are not transfused. The aim of this manuscript is to review the clinical manifestations, complications, genetic defects, and unmet treatments needs in TI.


Asunto(s)
Talasemia beta/diagnóstico , Talasemia beta/terapia , Transfusión Sanguínea , Humanos , Quelantes del Hierro/uso terapéutico , Úlcera de la Pierna/etiología , Guías de Práctica Clínica como Asunto , Calidad de Vida , Talasemia beta/complicaciones , Talasemia beta/genética , gammaglobulinas/biosíntesis
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...