RESUMEN
Dengue infection can cause a wide spectrum of presentations extending from simple self-limiting febrile illness to severe dengue, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Dengue associated hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by the uncontrolled activation of macrophages and T cells, eliciting clusters of symptoms and signs and abnormal biochemical parameters. Herein we report a 28-year-old Sri Lankan female with no past medical history who presented with dengue hemorrhagic fever and diabetic ketoacidosis complicated with hemophagocytic lymphohistiocytosis. She was treated with a three-day course of intravenous methylprednisolone in addition to standard care for diabetic ketoacidosis and dengue hemorrhagic fever. She made an uneventful recovery.
RESUMEN
The dengue virus is a mosquito-borne flavivirus that causes dengue fever (DF), dengue hemorrhagic fever, and dengue shock syndrome. DF is characterized by fever, headache, arthralgia, retro-orbital pain, and skin rashes. However, some patients with DF develop post-dengue fatigue syndrome (PDFS) following their initial febrile episode. Fatigue is common during the febrile episode of DF; however, PDFS is defined as the presence of a stubborn sense of tiredness that results in a decreased capacity for physical and mental work. PDFS carries a spectrum of musculoskeletal and neurological features. Following the recovery of DF, vasomotor symptoms such as hot flashes, excess sweating, and mood changes are rare. We present the first reported case of PDFS in a young woman in Sri Lanka.
