Enhanced angiogenesis following allogeneic blood transfusion.

Blood transfusions are associated with recurrence of solid cancers. Angiogenesis is essential for cancer growth. Our aim was to determine for the first time in a prospective cohort study the effect of prestorage allogeneic leucodepleted SAGM (saline, adenine, glucose, mannitol) red cell transfusion on angiogenic factor levels and in vitro angiogenesis. Forty pretransfusion adult hospital inpatients were selected consecutively. Serum vascular endothelial growth factor (VEGF) and endostatin were measured in each patient before and after prestorage allogeneic leucodepleted SAGM red cell transfusion. All samples were exposed to an in vitro endothelial cell proliferation assay and 10 sample groups were also exposed to an in vitro whole angiogenesis assay. The median number of units transfused was 2 (minimum-maximum, 2-4). Twenty-nine (73%) patients had a rise in VEGF, with an overall increase of 118 pg/ml (quartiles -5, 306; P < 0.01). Twenty-eight (70%) patients had a decrease in endostatin, with an overall reduction of 1.2 ng/ml (quartiles 4.0, 0.0; P = 0.017). There was an overall 33% increase in endothelial cell proliferation (P < 0.01) and a 9.4% increase in in vitro whole assay angiogenesis (P < 0.01). Prestorage allogeneic leucodepleted SAGM red cell transfusions are associated with a favourable angiogenic factor imbalance and an elevation in in vitro angiogenesis.

Can selection assessments predict students' achievements in the premedical year?: a study at Arabian Gulf University.

BACKGROUND: In a problem-based learning (PBL) program, students are encouraged to develop self-motivation, self-confidence, communication skills and problem-solving skills. Measuring these attributes when selecting students into medical schools is a formidable task. Admission to medical school typically depends upon students' academic achievement in their prior education. In the past 3 years the College of Medicine and Medical Science (CMMS) at the Arabian Gulf University, which has a PBL curriculum, adopted an admission policy that utilizes final high school scores, a written admission examination in English and science, as well as a structured interview. OBJECTIVE: To determine the extent to which the admissions measures predict academic achievement in the first year of studies at CMMS. DESIGN: Prediction study of prospectively collected data. Final cumulative score for all subjects at the end of the first year was the main dependent variable analyzed. SUBJECTS: All students admitted to the college during the academic year 1998-1999. RESULTS: The written admission science examination scores had the highest correlation (r =0.663, p< 0.05) with the Year 1 final cumulative score. Although the admission interview focused on non-cognitive student attributes, which may or may not affect the students' academic performance, its score had a statistically significant, if low, correlation with the Year 1 final cumulative score (r =0.275, p< 0.012). Approximately 59% of the total variability of the Year 1 final cumulative scores could be explained by the admission examination scores in science and English and the high school scores. CONCLUSION: Procedures for selecting students who are most likely to succeed academically in the initial year at an innovative medical school deserve further study and probably should include both academic performance and non-academic attributes.