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Biochem Biophys Res Commun ; 281(1): 78-83, 2001 Feb 16.
Artículo en Inglés | MEDLINE | ID: mdl-11178963

RESUMEN

The effects of advanced glycation end-products (AGEs) on retinal microvascular cell glycosphingolipids were investigated as a potential pathogenic mechanism of diabetic retinopathy. The results obtained showed that, in microvascular retinal endothelial cells and pericytes, AGEs increased the amount of all glycosphingolipids studied (from 25 to 115% depending on the glycosphingolipid species), except for a specific ganglioside, GD3, which decreased by 35% only in pericytes. Glycosphingolipid profiles and GM3 fatty acid analysis did not show any qualitative differences after incubation with AGEs, suggesting that AGEs only induced quantitative changes in cell glycosphingolipids. These results show a new metabolic effect of AGEs, which could be involved in the microvascular alterations observed in diabetic retinopathy.


Asunto(s)
Retinopatía Diabética/metabolismo , Productos Finales de Glicación Avanzada/metabolismo , Glicoesfingolípidos/metabolismo , Microcirculación/metabolismo , Animales , Apoptosis , Bovinos , División Celular , Células Cultivadas , Cromatografía Líquida de Alta Presión , Endotelio Vascular/metabolismo , Ácidos Grasos/metabolismo , Gangliósidos/metabolismo , Modelos Biológicos
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