RESUMEN
The Consort suborbital rocket program was initiated to allow industrial researchers working through the various NASA Centers for Commercial Development of Space to have ready access to 6 to 7 min of microgravity environment for the purpose of trying out new ideas and for testing apparatus being developed for longer duration Shuttle flights. The 6 Consort flights have provided a wealth of experimental data, some of which has not been published in the open literature. The purpose of this paper is to document the experiments that have been flown and what has been learned. A fairly extensive bibliography of the published results has been included, and the investigator team responsible for the various experiments has been included so that interested parties may contact the various investigators directly for more details.
Asunto(s)
Biotecnología/métodos , Vuelo Espacial/tendencias , Nave Espacial/instrumentación , Ingravidez , Aceleración , Biotecnología/instrumentación , Galvanoplastia/instrumentación , Galvanoplastia/métodos , Polímeros/química , Investigación , Goma/química , Vuelo Espacial/instrumentación , Estados Unidos , United States National Aeronautics and Space AdministrationRESUMEN
One of the major stumbling blocks that prevents rapid structure determination using x-ray crystallography is macromolecular crystal growth. There are many examples where crystallization takes longer than structure determination. In some cases, it is impossible to grow useful crystals on earth. Recent experiments conducted in conjunction with NASA on various Space Shuttle missions have demonstrated that protein crystals often grow larger and display better internal molecular order than their earth-grown counterparts. This paper reports results from three Shuttle flights using the Protein Crystallization Facility (PCF). The PCF hardware produced large, high-quality insulin crystals by using a temperature change as the sole means to affect protein solubility and thus, crystallization. The facility consists of cylinders/containers with volumes of 500, 200, 100, and 50 ml. Data from the three Shuttle flights demonstrated that larger, higher resolution crystals (as evidenced by x-ray diffraction data) were obtained from the microgravity experiments when compared to earth-grown crystals.