Autoimmune inner ear disease associated with antiphospholipid antibodies.

OBJECTIVES: The percentage of autoimmune diseases in Western countries is approximately 8% of the total population. Despite numerous studies indicating an increase in prevalence and incidence over the past two decades, autoimmune vestibular disorders seem to be underdiagnosed, primarily due to the lack of a definitive test capable of identifying the specific antigen of the inner ear. Autoimmune inner ear disease (AIED) is defined as a rapidly progressive and often fluctuating bilateral neurosensorial hearing loss that develops over a period of weeks or months. AIED can affect only the inner ear or be part of systemic diseases such as granulomatosis with polyangiitis, Cogan's syndrome, systemic lupus erythematosus, polyarteritis nodosa, or relapsing polychondritis, among others. Our main objective was to conduct a study on the presence of antiphospholipid antibodies (aPL) in patients with AIED seen in a specialised clinic. METHODS: We designed an observational retrospective study in which we selected patients from a total group of 55 with AIED referred to the Autoimmune Diseases Clinic, those with confirmed positivity for antiphospholipid antibodies, and described their clinical, analytical, and epidemiological characteristics. RESULTS: We found a prevalence of 29% positivity for antiphospholipid antibodies, with lupus anticoagulant (LA) being the most frequently detected, followed by anticardiolipin (aCL) and anti-beta2 glycoprotein (anti-B2GP). Double positivity was observed in 25% of patients. The main clinical manifestations were bilateral hearing loss, vestibular symptoms, and tinnitus. Only 25% of patients experienced audiometric improvement during the course of the disease. CONCLUSIONS: We emphasise the importance of identifying the presence of aPL in AIED, enabling the establishment of appropriate and specific therapeutic management to prevent audiometric deterioration.

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self-administered questionnaires were used to assess psychological variables. A time × group interaction effect was found (p = 0.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (p = 0.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (p = 0.004) as well as with SSc (p = 0.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases.

[Scales for social support for eating habits and exercise: psychometric properties]. / Escalas de apoyo social para los hábitos alimentarios y para el ejercicio: propiedades psicométricas.

OBJECTIVE: Social support can introduce favorable changes in lifestyle to reduce the cardiovascular risk. The aim of this study was to verify these changes in the clinical population participating in this study and present the psychometric properties of the scales of social support for 'Eating Habits' and 'Exercise' in patients diagnosed with metabolic syndrome. METHODS: 135 participants attending a programme for changing lifestyle habits. Sociodemographic, psychological, and lifestyle variables were assessed at the Hospital Universitario Virgen de las Nieves (HUVN) in Granada (Spain) between 2013 and 2014. The following procedures were used: Confirmatory factor analysis (CFA), internal consistency, sensibility to change and temporal stability. RESULTS: The AFC confirmed the original structure of both scales, except for the exclusion of factor 2 (family) from the social support scale for the year. For the social support scale, the local adjustment, all items presented high values of factor loads and individual reliability (λ≥0.64 and R2≥0.41, respectively). For the exercise scale, the local adjustment, the items presented high values of factor loads and individual reliability (λ≥0.62 and R2≥0.38, respectively). Internal consistency values were between adequate and excellent, with Cronbach's alpha figures between 0.714 and 0.864. Regarding sensitivity to change, the experimental group increased the perception of social support for food and exercise. The control group did not show significant differences. CONCLUSIONS: Our results show adequate indices for validity and reliability of the measures. Both measures appeared to be useful to assess social support in patients diagnosed with metabolic syndrome.

OBJETIVO: El apoyo social puede introducir cambios favorables en el estilo de vida de cara a reducir el riesgo cardiovascular. El objetivo de este estudio fue verificar dichos cambios en la población clínica que participó en el mismo y presentar las propiedades psicométricas de dos escalas de apoyo social: los hábitos alimentarios y el ejercicio. Ambas fueron aplicadas en pacientes con síndrome metabólico (SM). METODOS: Participaron 135 sujetos en un programa de modificación de estilo de vida. Las medidas sociodemográficas, psicológicas y de estilo de vida fueron tomadas en el Hospital Universitario Virgen de las Nieves (HUVN) de Granada (España) durante 2013 y 2014. Se realizaron los siguientes análisis: análisis factorial confirmatorio(AFC), de la consistencia interna, de la sensibilidad al cambio y de la estabilidad temporal. RESULTADOS: El AFC confirmó la estructura original de ambas escalas, excepto por la exclusión del factor 2 (familia) de la escala de apoyo social para el ejercicio. Para la escala de apoyo social, el ajuste local, todos los ítems presentaron altos valores de cargas factoriales y fiabilidades individuales (λ≥0,64 y R2≥0,41, respectivamente). Para la escala de ejercicio, el ajuste local, los ítems presentaron altos valores de cargas factoriales y fiabilidades individuales (λ≥0,62 y R2≥0,38, respectivamente). Los valores de consistencia interna resultaron entre adecuados y excelentes, con cifras de alfa de Cronbach entre 0,714 y 0,864. En cuanto a la sensibilidad al cambio, el grupo experimental aumentó la percepción del apoyo social para la alimentación y para el ejercicio. El grupo de control no presentó diferencias significativas. CONCLUSIONES: Los resultados muestran niveles adecuados de validez y fiabilidad, demostrando que las escalas son adecuadas para evaluar el apoyo social en pacientes con SM.

Thrombotic microangiopathy in a patient with eosinophilic granulomatosis with polyangiitis: case-based review.

The correct diagnosis, classification and therapeutic management of thrombotic microangiopathies (TMA) continue to be a challenge for the clinician. We report a rare case of eosinophilic granulomatosis with polyangiitis (EGPA) as a trigger for complement-mediated TMA in a 57-year-old man who was successfully treated with corticoids, cyclophosphamide and therapeutic plasma exchange. Additionally, we review few other cases reported in the literature and the pathophysiological pathway of association between TMA and EGPA. We found that the mutual relationships between the inflammation triggered by vasculitis, the exacerbated complement activation, together with hypereosinophilia and endothelial damage seem to be the key in explaining the connection between both entities. We suggest that an understanding of the multi-causal nature of TMAs is crucial for the correct diagnosis and treatment of these patients.

Escalas de apoyo social para los hábitos alimentarios y para el ejercicio: propiedades psicométricas / Scales for social support for eating habits and exercise: psychometric properties

OBJETIVO: El apoyo social puede introducir cambios favorables en el estilo de vida de cara a reducir el riesgo cardiovascular. El objetivo de este estudio fue verificar dichos cambios en la población clínica que participó en el mismo y presentar las propiedades psicométricas de dos escalas de apoyo social: los hábitos alimentarios y el ejercicio. Ambas fueron aplicadas en pacientes con síndrome metabólico (SM). MÉTODOS: Participaron 135 sujetos en un programa de modificación de estilo de vida. Las medidas sociodemográficas, psicológicas y de estilo de vida fueron tomadas en el Hospital Universitario Virgen de las Nieves (HUVN) de Granada (España) durante 2013 y 2014. Se realizaron los siguientes análisis: análisis factorial confirmatorio(AFC), de la consistencia interna, de la sensibilidad al cambio y de la estabilidad temporal. RESULTADOS: El AFC confirmó la estructura original de ambas escalas, excepto por la exclusión del factor 2 (familia) de la escala de apoyo social para el ejercicio. Para la escala de apoyo social, el ajuste local, todos los ítems presentaron altos valores de cargas factoriales y fiabilidades individuales (lamda≥0,64 y R2≥0,41, respectivamente). Para la escala de ejercicio, el ajuste local, los ítems presentaron altos valores de cargas factoriales y fiabilidades individuales (lamda≥0,62 y R2≥0,38, respectivamente). Los valores de consistencia interna resultaron entre adecuados y excelentes, con cifras de alfa de Cronbach entre 0,714 y 0,864. En cuanto a la sensibilidad al cambio, el grupo experimental aumentó la percepción del apoyo social para la alimentación y para el ejercicio. El grupo de control no presentó diferencias significativas. CONCLUSIONES: Los resultados muestran niveles adecuados de validez y fiabilidad, demostrando que las escalas son adecuadas para evaluar el apoyo social en pacientes con SM

OBJECTIVE: Social support can introduce favorable changes in lifestyle to reduce the cardiovascular risk. The aim of this study was to verify these changes in the clinical population participating in this study and present the psychometric properties of the scales of social support for 'Eating Habits' and 'Exercise' in patients diagnosed with metabolic syndrome. METHODS: 135 participants attending a programme for changing lifestyle habits. Sociodemographic, psychological, and lifestyle variables were assessed at the Hospital Universitario Virgen de las Nieves (HUVN) in Granada (Spain) between 2013 and 2014. The following procedures were used: Confirmatory factor analysis (CFA), internal consistency, sensibility to change and temporal stability. RESULTS: The AFC confirmed the original structure of both scales, except for the exclusion of factor 2 (family) from the social support scale for the year. For the social support scale, the local adjustment, all items presented high values of factor loads and individual reliability (lamda≥0.64 and R2≥0.41, respectively). For the exercise scale, the local adjustment, the items presented high values of factor loads and individual reliability (lamda≥0.62 and R2≥0.38, respectively). Internal consistency values were between adequate and excellent, with Cronbach's alpha figures between 0.714 and 0.864. Regarding sensitivity to change, the experimental group increased the perception of social support for food and exercise. The control group did not show significant differences. CONCLUSIONS: Our results show adequate indices for validity and reliability of the measures. Both measures appeared to be useful to assess social support in patients diagnosed with metabolic syndrome

[Validity and reliability of the self-efficacy to regulate exercise scale in patients with metabolic syndrome]. / Validez y fiabilidad de la escala de autoeficacia para el ejercicio físico en pacientes con síndrome metabólico.

OBJECTIVE: Self-efficacy refers to beliefs in individuals' own capacities to do something. With the intent of evaluate the validity and reliability, we investigated the psychometric properties of the Self-Efficacy to Regulate Exercise Scale (SERES) in patients with metabolic syndrome (MetS). METHODS: 135 participants with medical diagnosis of MetS took part in the study (Mage=55.5, SD=7.6). We investigated sociodemographic, psychological, and life-style variables. Participants were recruited at the Hospital Universitario Virgen de las Nieves (HUVN) in Granada (Spain) between 2013 and 2014. In order to characterise the sample, descriptive statistics were used. Factorial analysis, internal consistency and convergent reliability of the SERES were also calculated. Group differences were investigated using Student's t test. RESULTS: A solution with two factors was extracted, which explained 72.7% of the variance of the SERES. The internal consistency values for the total score of the SERES were (0.925 and 0.864) according to the values of Cronbach's alpha and Guttman's two halves, respectively. Significant correlations of the SERES were detected for with physical exercise, assertiveness, stress, anger, and active life-style (e.g., renouncing to sedentary behaviours). CONCLUSIONS: This was the first study to report on psychometric properties of the SERES. Results supported the adequacy of the measure for use with patients with MetS. SERES seemed to be useful in evaluating self-efficacy in relation to physical exercise, psychosocial, and lifestyle variables.

OBJETIVO: La autoeficacia percibida se refiere a la creencia en la propia capacidad para hacer algo. El objetivo de este trabajo fue obtener la validez y la fiabilidad de la escala de autoeficacia para el ejercicio físico (AEEF) en pacientes con síndrome metabólico (SM) y para ello fueron verificadas las propiedades psicométricas de la misma. METODOS: Participaron en el estudio 135 sujetos con una edad media de 55,5 años (DT=7,6) que cumplían los criterios diagnósticos para el SM. Se tomaron medidas sociodemográficas, psicológicas y de estilo de vida de los mismos. Los sujetos fueron reclutados en el Hospital Universitario Virgen de las Nieves (HUVN) de Granada (España) durante los años de 2013 a 2014. La caracterización de la muestra fue realizada a través de análisis descriptivos. Se realizó el análisis factorial, de la consistencia interna y de validez convergente del AEEF; las diferencias intra e intergrupales fueron evaluadas a través de la prueba t de Student. RESULTADOS: Extrajimos una solución de 2 factores que explicaron el 72,7% de la varianza común. Los valores de consistencia interna para la puntuación total de la AEEF fueron de (0,925 y 0,864) según los valores del alfa de Cronbach y del método de las dos mitades de Guttman, respectivamente. Las correlaciones de la AEEF con la frecuencia de la práctica de ejercicios, la renuncia al sedentarismo, la asertividad, el estrés y la ira fueron estadísticamente significativas. CONCLUSIONES: Este es el primer estudio sobre las propiedades psicométricas de la versión española de la AEEF. Los resultados mostraron niveles aceptables de validez y fiabilidad en pacientes con SM. La escala demostró ser útil para evaluar la asociación de la autoeficacia relativa al ejercicio físico con distintas variables psicosociales y de estilo de vida.

Estrés, ira y dieta mediterránea como factores predictores del síndrome metabólico / Stress, anger and Mediterranean diet as predictors of metabolic syndrome

Antecedentes y objetivo: El síndrome metabólico (SM) es un conjunto de condiciones metabólicas que incluyen obesidad abdominal, reducción de las concentraciones de colesterol unido a las high density lipoproteins (c-HDL, «lipoproteínas de alta densidad»), triglicéridos elevados, aumento de la presión arterial e hiperglucemia. Dado que se trata de una enfermedad multicausal, el objetivo de este estudio es identificar las variables psicológicas, emocionales y de estilo de vida que pueden ejercer una influencia sobre los diferentes componentes del SM. Pacientes y métodos: Estudio transversal con 103 pacientes diagnosticados de SM (47 varones y 56 mujeres). Se recogieron medidas antropométricas, clínicas y analíticas para valorar las variables asociadas al SM. También se evaluaron las principales variables psicológicas y emocionales. Resultados: Se realizaron diferentes pruebas de regresión lineal múltiple para identificar qué variables eran predictoras del SM. Las variables dependientes fueron el índice de masa corporal (IMC), la circunferencia abdominal, el c-HDL y la calidad de vida, y las variables predictoras fueron el estrés psicológico, la ira y la adherencia a la dieta mediterránea. Los resultados mostraron que el estrés psicológico era un predictor de la calidad de vida (β=−0,55, p≤0). De igual modo, la ira fue un predictor del IMC (β=0,23, p=0,047) y de la circunferencia abdominal (β=0,27, p=0,021). Según lo previsto, la adherencia a la dieta mediterránea fue un predictor del c-HDL (β=0,2, p=0,045) y de la calidad de vida (β=−0,18, p=0,031). Conclusiones: Los resultados confirman un vínculo entre la adherencia a ciertos hábitos alimentarios y el estilo de vida; sin embargo, se sitúan un paso por delante y resaltan la importancia de los factores psicológicos y emocionales como el estrés y la ira en algunos componentes del SM

Background and objective: Metabolic syndrome (MetS) is a cluster of metabolic conditions that include abdominal obesity, reduction in cholesterol concentrations linked to high density lipoproteins (HLDc), elevated triglycerides, increased blood pressure and hyperglycaemia. Given that this is a multicausal disease, the aim of this study is to identify the psychological, emotional and lifestyle variables that can have an influence on the different MetS components. Patients and methods: A cross-sectional study with 103 patients with diagnostic criteria for MetS (47 male and 56 female). Anthropometric, clinical and analytical measurements were collected to assess the variables associated with MetS. The main psychological and emotional variables were also assessed. Results: Different multiple linear regression tests were performed to identify which variables were predictive of MetS. The dependent variables were body mass index (BMI), abdominal circumference, HDLc, and quality of life, and the predictive variables were psychological stress, anger and adherence to a Mediterranean diet. The results showed that psychological stress was a predictor of quality of life (β=−0.55, P≤0). Similarly, anger was a predictor of BMI (β=0.23, P=.047) and abdominal circumference (β=0.27, P=.021). As expected, adherence to a Mediterranean diet was a predictor of HDLc (β=0.2, P=.045) and of quality of life (β=−0.18, P=.031). Conclusions: The results confirm a link between adherence to certain dietary habits and lifestyle, however they go one step further and show the importance of psychological and emotional factors like psychological stress and anger in some MetS components

Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus.

OBJECTIVES: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. METHODS: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. RESULTS: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. CONCLUSIONS: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting.

Adherencia al tratamiento en pacientes con lupus eritematoso sistémico / Adherence to treatment in patients with systemic lupus erythematosus

Antecedentes y objetivo: El incumplimiento terapéutico constituye un importante problema asistencial en pacientes con lupus eritematoso sistémico (LES). Conocer los factores asociados de este puede ser de gran utilidad en el ámbito clínico. El objetivo de esta investigación fue analizar la influencia de las variables sociodemográficas, clínicas y psicológicas sobre la adherencia al tratamiento en una muestra española de mujeres con LES. Pacientes y método: En este estudio transversal-observacional se evaluó el grado de adherencia al tratamiento, el estado clínico y psicopatológico, el estrés psicológico y la autoeficacia en mujeres con LES. La muestra se dividió en 2 grupos: adherentes y no adherentes. Mediante un análisis de regresión logística se identificaron los factores asociados a la falta de adherencia en esta población. Resultados: Se evaluaron 72 pacientes (edad media: 36,7±12,2 años). El 63,9% no tuvieron adherencia. Un bajo nivel educativo, estar desempleada, vivir en pareja y el consumo de alcohol se asociaron a una baja adhesión al tratamiento. Se encontraron diferencias entre el grupo adherente y el no adherente en las subescalas psicopatológicas de somatización, obsesión-compulsión e índices psicopatológicos generales, así como en el estrés percibido, obteniendo puntuaciones más altas las pacientes adherentes. El uso de antiinflamatorios no esteroideos (AINE), tener artrosis y mayor alteración psicopatológica fueron predictores significativos de la adherencia al tratamiento, explicando entre el 35 y el 47% de la variabilidad de esta. Conclusiones: La falta de adherencia al tratamiento de las pacientes con LES fue alta y parece estar influida por factores clínicos y psicopatológicos (AU)

Background and objective: Non-adherence to treatment is usually a clinical problem in patients with systemic lupus erythematosus (SLE). Increasing the knowledge of predictors of treatment adherence can be meaningful in the clinical setting. The main objective of the present study was to analyse the influence of sociodemographic, clinical and psychological variables on the degree of treatment adherence in a sample of Spanish women with SLE. Patients and method: This is an observational-transversal study. All participants were evaluated for the degree of treatment adherence, their clinical status, psychopathological manifestations, the level of perceived stress and self-efficacy. The sample was divided into two groups (adherent vs non-adherent). The factors associated with a lack of adherence in this sample were analysed by means of logistic regression. Results: This study comprises 72 women with SLE (average age=36.72±12.2 years). Almost 64% of patients with SLE were non-adherent to treatment. The results showed that a low educational level, being unemployed, living with a partner and alcohol abuse were associated with low treatment adherence. There were significant mean differences between groups in psychopathological subscales of somatisation, obsession-compulsion and general psychopathological indices. There were also mean differences between groups for the level of perceived stress. The use of non-steroidal anti-inflammatory drugs, suffering arthrosis and scoring higher in dimensions of psychopathology were significant predictors of treatment adherence, explaining between 35% and 47% of its variability. Conclusions: Including the clinical and psychopathological manifestations as important aspects in the clinical reasoning of health professionals could improve the adherence to treatment of patients with SLE (AU)

Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study.

AIM: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE). METHOD: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups. RESULTS: Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile. CONCLUSION: Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events.

Adherence to treatment in patients with systemic lupus erythematosus. / Adherencia al tratamiento en pacientes con lupus eritematoso sistémico.

BACKGROUND AND OBJECTIVE: Non-adherence to treatment is usually a clinical problem in patients with systemic lupus erythematosus (SLE). Increasing the knowledge of predictors of treatment adherence can be meaningful in the clinical setting. The main objective of the present study was to analyse the influence of sociodemographic, clinical and psychological variables on the degree of treatment adherence in a sample of Spanish women with SLE. PATIENTS AND METHOD: This is an observational-transversal study. All participants were evaluated for the degree of treatment adherence, their clinical status, psychopathological manifestations, the level of perceived stress and self-efficacy. The sample was divided into two groups (adherent vs non-adherent). The factors associated with a lack of adherence in this sample were analysed by means of logistic regression. RESULTS: This study comprises 72 women with SLE (average age=36.72±12.2 years). Almost 64% of patients with SLE were non-adherent to treatment. The results showed that a low educational level, being unemployed, living with a partner and alcohol abuse were associated with low treatment adherence. There were significant mean differences between groups in psychopathological subscales of somatisation, obsession-compulsion and general psychopathological indices. There were also mean differences between groups for the level of perceived stress. The use of non-steroidal anti-inflammatory drugs, suffering arthrosis and scoring higher in dimensions of psychopathology were significant predictors of treatment adherence, explaining between 35% and 47% of its variability. CONCLUSIONS: Including the clinical and psychopathological manifestations as important aspects in the clinical reasoning of health professionals could improve the adherence to treatment of patients with SLE.

Stress, anger and Mediterranean diet as predictors of metabolic syndrome. / Estrés, ira y dieta mediterránea como factores predictores del síndrome metabólico.

BACKGROUND AND OBJECTIVE: Metabolic syndrome (MetS) is a cluster of metabolic conditions that include abdominal obesity, reduction in cholesterol concentrations linked to high density lipoproteins (HLDc), elevated triglycerides, increased blood pressure and hyperglycaemia. Given that this is a multicausal disease, the aim of this study is to identify the psychological, emotional and lifestyle variables that can have an influence on the different MetS components. PATIENTS AND METHODS: A cross-sectional study with 103 patients with diagnostic criteria for MetS (47 male and 56 female). Anthropometric, clinical and analytical measurements were collected to assess the variables associated with MetS. The main psychological and emotional variables were also assessed. RESULTS: Different multiple linear regression tests were performed to identify which variables were predictive of MetS. The dependent variables were body mass index (BMI), abdominal circumference, HDLc, and quality of life, and the predictive variables were psychological stress, anger and adherence to a Mediterranean diet. The results showed that psychological stress was a predictor of quality of life (ß=-0.55, P≤0). Similarly, anger was a predictor of BMI (ß=0.23, P=.047) and abdominal circumference (ß=0.27, P=.021). As expected, adherence to a Mediterranean diet was a predictor of HDLc (ß=0.2, P=.045) and of quality of life (ß=-0.18, P=.031). CONCLUSIONS: The results confirm a link between adherence to certain dietary habits and lifestyle, however they go one step further and show the importance of psychological and emotional factors like psychological stress and anger in some MetS components.

Validez y fiabilidad de la escala de autoeficacia para el ejercicio físico en pacientes con síndrome metabólico / Validity and reliability of the self-efficacy to regulate exercise scale in patients with metabolic syndrome

Fundamentos: La autoeficacia percibida se refiere a la creencia en la propia capacidad para hacer algo. El objetivo de este trabajo fue obtener la validez y la fiabilidad de la escala de autoeficacia para el ejercicio físico (AEEF) en pacientes con síndrome metabólico (SM) y para ello fueron verificadas las propiedades psicométricas de la misma. Métodos: Participaron en el estudio 135 sujetos con una edad media de 55,5 años (DT=7,6) que cumplían los criterios diagnósticos para el SM. Se tomaron medidas sociodemográficas, psicológicas y de estilo de vida de los mismos. Los sujetos fueron reclutados en el Hospital Universitario Virgen de las Nieves (HUVN) de Granada (España) durante los años de 2013 a 2014. La caracterización de la muestra fue realizada a través de análisis descriptivos. Se realizó el análisis factorial, de la consistencia interna y de validez convergente del AEEF; las diferencias intra e intergrupales fueron evaluadas a través de la prueba t de Student. Resultados: Extrajimos una solución de 2 factores que explicaron el 72,7% de la varianza común. Los valores de consistencia interna para la puntuación total de la AEEF fueron de (0,925 y 0,864) según los valores del alfa de Cronbach y del método de las dos mitades de Guttman, respectivamente. Las correlaciones de la AEEF con la frecuencia de la práctica de ejercicios, la renuncia al sedentarismo, la asertividad, el estrés y la ira fueron estadísticamente significativas Conclusiones: Este es el primer estudio sobre las propiedades psicométricas de la versión española de la AEEF. Los resultados mostraron niveles aceptables de validez y fiabilidad en pacientes con SM. La escala demostró ser útil para evaluar la asociación de la autoeficacia relativa al ejercicio físico con distintas variables psicosociales y de estilo de vida

Background: Self-efficacy refers to beliefs in individuals' own capacities to do something. With the intent of evaluate the validity and reliability, we investigated the psychometric properties of the Self-Efficacy to Regulate Exercise Scale (SERES) in patients with metabolic syndrome (MetS). Methods: 135 participants with medical diagnosis of MetS took part in the study (Mage=55.5, SD=7.6). We investigated sociodemographic, psychological, and life-style variables. Participants were recruited at the Hospital Universitario Virgen de las Nieves (HUVN) in Granada (Spain) between 2013 and 2014. In order to characterise the sample, descriptive statistics were used. Factorial analysis, internal consistency and convergent reliability of the SERES were also calculated. Group differences were investigated using Student's t test. Results: A solution with two factors was extracted, which explained 72.7% of the variance of the SERES. The internal consistency values for the total score of the SERES were (0.925 and 0.864) according to the values of Cronbach's alpha and Guttman's two halves, respectively. Significant correlations of the SERES were detected for with physical exercise, assertiveness, stress, anger, and active life-style (e.g., renouncing to sedentary behaviours) Conclusions: This was the first study to report on psychometric properties of the SERES. Results supported the adequacy of the measure for use with patients with MetS. SERES seemed to be useful in evaluating self-efficacy in relation to physical exercise, psychosocial, and lifestyle variables

Analyses of hair and salivary cortisol for evaluating hypothalamic-pituitary-adrenal axis activation in patients with autoimmune disease.

Although many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal axis (HPA), controversial results have been described. Our objective was to study HPA axis activity in women with autoimmune disease compared to healthy women. Therefore, we analyzed salivary cortisol over the course of a day, and hair cortisol concentrations from the three preceding months, from 65 women divided into two groups: healthy women (n = 30), with a mean age of 44.70 ± 11.65 years; and women with autoimmune disease (n = 35), with a mean age of 48.26 ± 9.04 years. The latter group comprises women with systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). Perceived stress and psychopathological symptomatology were also evaluated. Autoimmune disease group scored higher on the somatization subscale SCL-90-R and lower on the anxiety subscale than the control group. Regarding HPA axis activation, the area under curve for cortisol levels during the day was higher for the autoimmune disease group. In addition, higher cortisol levels in hair were found in the group with autoimmune disease. Our findings show greater short and long-term HPA axis activity in women with autoimmune disease than in healthy women.

Cuestionario de asertividad centrado en el estilo de vida (CACEV) en pacientes con síndrome metabólico: desarrollo y validación / The Lifestyle Related Assertiveness Questionnaire (LRAQ) in patients with metabolic syndrome: Development and validation

El objetivo de este trabajo es presentar las propiedades psicométricas del "Cuestionario de asertividad centrado en el estilo de vida" (CACEV) con una muestra de pacientes con síndrome metabólico. La muestra total fue de 136 sujetos de los que 79 terminaron el estudio (48 del grupo de tratamiento y 31 del grupo control), con seguimientos de 6 y 18 meses. Se han incluido los datos sociodemográficos, antropométricos, fisiológicos y bioquímicos de los participantes, aparte de las puntuaciones en el CACEV y en el "Inventario de asertividad" (IA). Los resultados del análisis factorial exploratorio del CACEV han revelado una estructura de tres factores: Expresar la preferencia por el ejercicio y la alimentación saludable, Decir que no al consumo de alimentos poco saludables y Decir que no a actividades obstaculizadoras del ejercicio físico. La consistencia interna (alfa= 0,925), la fiabilidad test-retest y la sensibilidad al cambio fueron adecuadas. Las propiedades psicométricas del CACEV indican que es un cuestionario válido y fiable para evaluar la asertividad centrada en el estilo de vida en personas con síndrome metabólica

The aim of this paper is to present the psychometric properties of the Lifestyle-Related Assertiveness Questionnaire (CACEV) in a sample of patients with metabolic syndrome. The total sample was 136 subjects, of whom 79 completed the study (48 from the treatment group and 31 from the control group), with follow-up at 6 and 18 months. Socio-demographic, anthropometric, physiological and biochemical data of the participants have been included, as well as the CACEV and the Assertiveness Inventory (AI) scores. The results of the exploratory factor analysis of CACEV have revealed a 3-factor structure: Expressing preference for exercise and healthy eating, Saying no to unhealthy food consumption and Saying no to activities that interfere with physical exercise. The internal consistency (alfa = .925), test-retest reliability and sensitivity to change were adequate. From the psychometric properties found in the CACEV, we can conclude that it is a valid and reliable questionnaire to evaluate lifestyle-related assertiveness in people with metabolic syndrome

Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study.

INTRODUCTION AND OBJECTIVES: The QT interval on the electrocardiogram has been shown to be longer in patients with systemic lupus erythematosus (SLE) compared to that of the general population. The clinical significance of this finding is unknown. The aim of this study was to assess the relationship between QT interval and subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity. MATERIAL AND METHODS: 93 patients with SLE and 109 healthy women with similar basal characteristics were studied. All patients underwent a 12- lead electrocardiogram, and corrected QT interval (QTc) was measured using the Bazett's formula. The presence of atherosclerosis was evaluated by carotid-femoral pulse-wave velocity. RESULTS: Clinical basal characteristics were similar in both groups. QTc interval was 415 ± 21.4 milliseconds in all patients, and 407 ± 19.1 milliseconds in the control group (p = 0.007). There was a positive correlation between QTc interval and carotid-femoral pulse-wave velocity (r = 0.235; p = 0.02) in patients with SLE. This association was independent of hypertension and age in a multivariate analysis. CONCLUSION: QTc interval measured by electrocardiogram is prolonged in SLE patients; it is related to subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity. This measure may help stratify risk in routine clinical practice and select the patients that might benefit from a more aggressive therapy in the prevention of cardiovascular events.