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J Psychiatr Res ; 142: 384-388, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34450553

RESUMEN

Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.


Asunto(s)
Trastornos Psicóticos , Esquizofrenia , Adolescente , Predisposición Genética a la Enfermedad , Alucinaciones , Humanos , Herencia Multifactorial/genética , Trastornos Psicóticos/epidemiología , Trastornos Psicóticos/genética , Factores de Riesgo , Esquizofrenia/epidemiología , Esquizofrenia/genética
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