Integration of molecular imaging in the personalized approach to neuroendocrine tumors.

NETs lesions can be difficult to characterize with conventional anatomic imaging (CT and MRI). Functional imaging techniques, and especially PET imaging, are very useful for detecting small neuroendocrine tumors that would not be seen with other techniques. The role of nuclear medicine in the localization, staging, restaging, treatment and monitoring of neuroendocrine tumors (NETs) has become progressively more relevant due to: the availability of tracers on new targets, tracers for positron emission tomography (PET); the development of cyclotrons and generators that allow this availability; as well as to hybrid systems (SPECT/CT, PET/CT and PET/MRI) that, by joining the functional and anatomical image, improve the quality of the images. Teragnosis, a new emerging therapy, in NET used receptor-mediated or nonreceptor- mediated mechanism to facilitate penetration and high-affinity binding between the radiopharmaceutical and the tumor cell. Teragnosis offers the possibility of personalized targeted radionuclide therapy.

Review on Sol-Gel Synthesis of Perovskite and Oxide Nanomaterials.

Sol-Gel is a low cost, well-established and flexible synthetic route to produce a wide range of micro- and nanostructures. Small variations in pH, temperature, precursors, time, pressure, atmosphere, among others, can lead to a wide family of compounds that share the same molecular structures. In this work, we present a general review of the synthesis of LaMnO3, SrTiO3, BaTiO3 perovskites and zinc vanadium oxides nanostructures based on Sol-Gel method. We discuss how small changes in the parameters of the synthesis can modify the morphology, shape, size, homogeneity, aggregation, among others, of the products. We also discuss the different precursors, solvents, working temperature, reaction times used throughout the synthesis. In the last section, we present novel uses of Sol-Gel with organic materials with emphasis on carbon-based compounds. All with a perspective to improve the method for future applications in different technological fields.

Differential Diagnosis of Hepatic Mass with Central Scar: Focal Nodular Hyperplasia Mimicking Fibrolamellar Hepatocellular Carcinoma.

Fibrolamellar hepatocellular carcinoma is a primary hepatic tumor that usually appears in young adults. Radical surgery is considered curative for this kind of tumor, so early diagnosis becomes essential for the prognosis of the patients. The main characteristic of this entity is the central scar, which is the center of differential diagnosis. We report the case of a 30-year-old man who was diagnosed with fibrolamellar hepatocellular carcinoma by ultrasonography. Contrast-enhanced CT confirmed this diagnosis, and the patient underwent a [18F] fluorocholine PET/CT. Hypermetabolism and the morphology in the nuclear medicine exploration suggest neoplastic nature of the lesion. Radical surgery was performed, and histopathologic analysis was performed, which resulted in focal nodular hyperplasia. Hepatic masses with central scar could have a difficult differential diagnosis, and focal nodular hyperplasia could mimic fibrolamellar hepatocellular carcinoma imaging patterns. These morphofunctional characteristics have not been described in [18F] Fluorocholine PET/CT, so there is a need to find out the potential role PET/CT in the differential diagnosis of hepatic mass with central scar.

Differences in kinematic and match-play demands between elite winning and losing wheelchair padel players.

We aimed to compare the match-play and kinematic demands of the translation and rotation movements of elite wheelchair padel players as a function of match results. Twenty-two elite male players were video-analysed with a two-dimensional direct linear transformation (DLT) -corrected video system across seven matches of a professional tournament. Distance, turns, changes of direction, linear and angular speed, acceleration and the players' heart rate (HR) were recorded. Losing couples in wheelchair padel covered greater distances than winners (P <0.001; r = 0.024) and did so at a higher speed (P <0.001; r = 0.06), while making greater efforts by accelerating (P <0.001; ∅ = -0.021), braking (P <0.001; ∅ = -0.014), and remaining less time stationary (P <0.001; ∅ = 0.059). In addition, losers performed more turns per rally (P <0.001; r = 0.04) at a faster speed, greater angular accelerations (P <0.001; V = 0.06) and greater average (P = 0.007; d = 0.91) and maximum (P = 0.20; d = 0.69) HR values. These data suggest that winner couples performed a better court positioning and employed a strategy to move the opponent during rallies in order to avoid them optimally reaching the ball.

Controlled dispersion of ZnO nanoparticles produced by basic precipitation in solvothermal processes.

Zinc oxide nanoparticles were successfully synthesized under precipitation processes, using ZnSO4·7H2O as a Zn2+ precursor and K2CO3 used as a basic source, and hydrozincite was obtained as an intermediary, which was treated under two procedures; first procedure involved multiple stages to get final precipitated with NaOH, and in the second procedure the hydrozincite was straightforwardly dried at 220 °C. By both processes ZnO structures were obtained, which were turned into nanoparticles by a solvothermal treatment, for four hours in ethylene glycol at 200 °C. The final products for the first procedure was conglomerate of spherical nanoparticles with sizes ranged between 5-10 nm and dispersed ellipsoidal nanoparticles for the second procedure. Apart off the two procedures mentioned above, another synthesis was carried out with the same Zn2+ precursor but now using NaOH, and the solvothermal treatment produced ZnO mixed micro-structures which under ultrasonic cavitation disaggregated on mesoporous ZnO nanoplates of hexagonal shapes with nanopore sizes of approximately 0.35 nm. All ZnOs synthesized were structurally characterized with XRD, TEM and FT-IR techniques, and electronically with UV-Vis absorption and diffuse reflectance spectroscopies.

Condiciones sociodemográficas y nivel de incertidumbre en mujeres ante el diagnóstico de cáncer de mama / Demographic conditions and level of uncertainty in women facing the diagnosis of breast cancer / Condições demográficas e nível de incerteza em mulheres para o diagnóstico de câncer de mama

OBJETIVO: Asociar las condiciones sociodemográficas y el nivel de incertidumbre en mujeres ante el diagnóstico de cáncer de mama en instituciones de salud, Cartagena. MATERIALES Y METODOLOGÍA: Estudio descriptivo correlacional, realizado a 108 mujeres con diagnóstico de menos de un año de cáncer de mama. Se utilizaron dos instrumentos, la encuesta sociodemográfica y la Escala de incertidumbre en la enfermedad para el adulto de Mishel. Los datos fueron almacenados en Excel y procesados en SPSS, para el análisis bivariado se utilizó la prueba de Chi cuadrado (Prob. de Chi cuadrado p < 0,05). RESULTADOS: El 60,2% presentó un regular nivel de incertidumbre, con mayor incidencia en el grupo de edad de 45-64 años y un nivel educativo bajo 47% (51). Al evaluar el marco de estímulos, 61,1% (66) no sabían si habría cambios en su tratamiento, no podían planear su futuro el 50,9% (55) y predecir el curso de su enfermedad el 60,2% (65). El 60,2% (65) reconoce al equipo de salud como responsable de su cuidado. Se encontró asociación entre la escolaridad y el nivel de incertidumbre con un valor de p=0,03. CONCLUSIONES: El grado de escolaridad se asoció con el nivel de incertidumbre presente en las participantes. Por ser la edad un factor predictor en esta enfermedad, se deben establecer acciones orientadas a su diagnóstico temprano. Como autoridad creíble, la enfermería debe realizar acciones de cuidado al momento del diagnóstico para disminuir interrogantes y la afectación emocional

OBJECTIVE: To associate sociodemographic conditions and the level of uncertainty in women facing the diagnosis of breast cancer in health institutions in Cartagena. METHODOLOGY: Descriptive, correlational study of 108 women with a diagnosis of less than one year breast cancer. Two instruments were used: the socio-demographic survey and the Mishel Uncertainty in Illness Scale for the adult. Data were organized in Excel and processed in SPSS. For bivariate analysis the Chi square (Prob. Chi square p <0.05) test was used. RESULTS: Sixty-point two percent had a regular level of uncertainty with the highest incidence in the 45-64 years old group and a low educational level 47% (51). In evaluating Stimulus Framework, 61.1% (66) they did not know whether there would be changes in treatment, they could not plan their future, 50.9% (55), and they could not predict the course of their disease 60.2% (65). Sixty-point two percent (65) recognize the health team as responsible for their care. Association between schooling and the level of uncertainty with a value of p = 0.03 was found. CONCLUSIONS: The level of education was associated with the level of uncertainty in the participants. Because age is a predictor factor in this disease, actions aimed at early diagnosis should be established. As a credible authority, nursing must perform care actions at the time of diagnosis to reduce questions and emotional distress

OBJETIVO: Associar condições sociodemográficas e o nível de incerteza em mulheres com o diagnóstico de câncer de mama em instituições de saúde, Cartagena. METODOLOGIA: Estudo descritivo correlacional, realizado em 108 mulheres diagnosticadas com menos de um ano de câncer de mama. Foram utilizados dois instrumentos, levantamento sócio-demográfico e a escala de incerteza na doença para adulto Mishel. Os dados foram organizados em Excel e processados em SPSS, para o teste de análise bivariada foi utilizada Chi quadrado (Prob. Chi quadrado p <0,05). RESULTADOS: 60,2% tinham um nível regular de incerteza, com maior incidência na faixa etária de 45-64 anos e um baixo nível educacional 47% (51). Na avaliação do quadro Estímulos 61,1% (66) não sabiam se haveria mudanças no tratamento, não podiam planejar seu futuro 50,9% (55) e não poderia prever o curso de sua doença 60,2% (65). 60,2% (65) reconhecem a equipe de saúde responsável pelo seu cuidado. Associação entre a escolaridade e o nível de incerteza com um valor de p = 0,03 foi encontrado. CONCLUSÕES: O nível de escolaridade foi associada com o nível de incerteza na participação. Como a idade um fator preditor nesta doença, deve estabelecer ações voltadas para o diagnóstico precoce. A enfermagem como uma autoridade credível e de modo deve tomar medidas para cuidar no momento do diagnóstico para reduzir dúvidas e envolvimento emocional