Asunto(s)
Antineoplásicos/uso terapéutico , Linfoma de Células B Grandes Difuso/terapia , Trasplante de Células Madre , Adulto , Anciano , Anticuerpos Monoclonales de Origen Murino/administración & dosificación , Femenino , Humanos , Linfoma de Células B Grandes Difuso/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Pronóstico , Inducción de Remisión , Estudios Retrospectivos , Rituximab , Acondicionamiento Pretrasplante , Trasplante Autólogo , Resultado del TratamientoAsunto(s)
Aminoglicósidos/administración & dosificación , Anticuerpos Monoclonales/administración & dosificación , Antineoplásicos/administración & dosificación , Movilización de Célula Madre Hematopoyética , Leucemia Promielocítica Aguda/terapia , Trasplante de Células Madre de Sangre Periférica , Acondicionamiento Pretrasplante , Anticuerpos Monoclonales Humanizados , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Femenino , Gemtuzumab , Humanos , Persona de Mediana Edad , Inducción de Remisión , Trasplante AutólogoAsunto(s)
Leucemia de Células T , Regresión Neoplásica Espontánea , Pancitopenia , Anciano , Anciano de 80 o más Años , Femenino , HumanosRESUMEN
We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and mu, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.
Asunto(s)
Crisis Blástica/patología , Médula Ósea/patología , Leucemia Neutrofílica Crónica/patología , Anciano , Crisis Blástica/genética , Transformación Celular Neoplásica , Proteínas de Fusión bcr-abl/genética , Reordenamiento Génico , Humanos , Leucemia Neutrofílica Crónica/genética , Masculino , Cromosoma Filadelfia , ARN Mensajero/genética , Receptores de Factor Estimulante de Colonias de Granulocito/genéticaRESUMEN
A patient with acute myeloid leukemia (AML)-M2 with t(8;21)(q22;q22) achieved complete remission with remission-induction chemotherapy followed by consolidation and intensification chemotherapies. T(8;21)(q22;q22) disappeared, but chimeric AML1/MTG8 was continuously detected in bone marrow cells. Following the development of therapy-related leukemia after 1 year, evolution of therapy-related AML-M4 with t(11;17)(q23;q25) and the rearrangement of the MLL gene were observed, while AML/MTG8 disappeared. After reinduction and following intermittent chemotherapies, a subsequent alternative transformation to AML-M2 occurred after detection of t(3;21)(q21;q22), with a break in the AML1 gene shown by interphase fluorescence in situ hybridization analysis. This leukemia transformed to AML-M4 after t(9;22)(q34;q11), with a minor BCR/ABL rearrangement, and then finally to AML-M2. This therapy-related leukemia was resistant to chemotherapy. These findings indicate that alterations in cytogenetic and molecular events caused by chemotherapeutic agents contribute to the sequential evolution of new leukemic clones with different morphology.
Asunto(s)
Cromosomas Humanos Par 21 , Cromosomas Humanos Par 8 , Leucemia Mieloide Aguda/genética , Neoplasias Primarias Secundarias/genética , Translocación Genética , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Células Clonales/patología , Citogenética , Evolución Molecular , Proteínas de Fusión bcr-abl/genética , Humanos , Leucemia Mielomonocítica Aguda/genética , Masculino , Neoplasias Primarias Secundarias/inducido químicamente , Neoplasias Primarias Secundarias/patología , Translocación Genética/efectos de los fármacosRESUMEN
Two cases of non-Hodgkin's lymphoma (NHL) generated within 6 months in first degree relatives, a father and a son, are presented. The NHL was a diffuse large B-cell type in the father and a small cleaved follicular type in the son. Cytogenetic and molecular studies of the lymphoma cells revealed the rearrangement of the immunoglobulin heavy chain (JH) gene in both patients, the mutation of p53 gene in the father and t(14; 18) (q32; q21) in the son. Both patients had low serum immunoglobulin levels. It is not known whether the occurrence of NHL in this family was incidental or pathogenetically related, since there was no clear common molecular abnormality between the father and the son. The pathogenetic mechanism of this familial occurrence of NHL is discussed.
Asunto(s)
Linfoma no Hodgkin/genética , Adulto , Anciano , Salud de la Familia , Genes p53/genética , Humanos , Cadenas Pesadas de Inmunoglobulina/genética , Linfoma no Hodgkin/etiología , Masculino , Mutación , LinajeRESUMEN
A man with refractory anemia and trisomy 8 complained of repeated febrile episodes. He exhibited oral aphtha, exanthema, genital ulcer, and epididymitis. Laboratory data obtained during febrile episodes revealed leukocytosis with elevated CRP and ESR. Repeated examinations for infectious bacterial agents were negative. HLA analysis detected HLA-B51. Behçet's disease of incomplete type was diagnosed and successfully treated with prednisolone. It was speculated that the repeated febrile episodes may have been a manifestation of neutrophil hyper-function induced by increased blood levels of inflammatory cytokines, including IL-6, IL-8 and G-CSF, in association with rare complications of Behçet's disease.
Asunto(s)
Anemia Refractaria/complicaciones , Síndrome de Behçet/complicaciones , Cromosomas Humanos Par 8 , Citocinas/sangre , Trisomía , Antiinflamatorios/uso terapéutico , Síndrome de Behçet/tratamiento farmacológico , Biomarcadores/sangre , Fiebre/etiología , Antígenos HLA-B/sangre , Antígeno HLA-B51 , Humanos , Masculino , Persona de Mediana Edad , Síndromes Mielodisplásicos/complicaciones , Neutrófilos/fisiología , Prednisolona/uso terapéutico , Recurrencia , Resultado del TratamientoAsunto(s)
Anemia Aplásica/inmunología , Leucocitos Mononucleares/inmunología , Glicoproteínas de Membrana/sangre , Síndromes Mielodisplásicos/inmunología , Anemia Aplásica/sangre , Anemia Refractaria/sangre , Anemia Refractaria/inmunología , Anemia Refractaria con Exceso de Blastos/sangre , Anemia Refractaria con Exceso de Blastos/inmunología , Antígenos de Superficie/sangre , Proteína Ligando Fas , Humanos , Síndromes Mielodisplásicos/sangre , Valores de ReferenciaRESUMEN
The quality of the sacred "temizu" water in shrines in Kyoto was surveyed. It was found that the sources of "temizu" were the municipal water supply or domestic wells and that the "temizu" was usually used for washing the hands and mouth, while in certain shrines it was drunk as well. Of 50 visitors responding to questions, 26 persons said that they drank "temizu". In some shrines using the municipal water supply as "temizu", the free residual chlorine concentration was lower than that in the municipal water supply itself. Contamination of "temizu" by Escherichia coli or Aeromonas hydrophila was observed in some shrines.