Asunto(s)
Comités Consultivos , Investigación Biomédica/métodos , Personal de Laboratorio Clínico/educación , Personal de Laboratorio Clínico/tendencias , Imagen Molecular/métodos , Medicina Nuclear/educación , Animales , Investigación Biomédica/tendencias , Educación de Postgrado en Medicina/métodos , Educación de Postgrado en Medicina/tendencias , Marcadores Fiduciales/tendencias , Humanos , Imagen por Resonancia Magnética/métodos , Imagen Molecular/tendencias , Imagen Multimodal/métodos , Medicina Nuclear/métodos , Medicina Nuclear/tendencias , Tomografía de Emisión de Positrones/métodos , Tomografía de Emisión de Positrones/tendencias , Radiofármacos , Sociedades MédicasAsunto(s)
Comités Consultivos , Educación de Postgrado en Medicina/métodos , Personal de Laboratorio Clínico/educación , Medicina Nuclear/educación , Medicina Nuclear/métodos , Educación de Postgrado en Medicina/tendencias , Humanos , Personal de Laboratorio Clínico/tendencias , Imagen Molecular/métodos , Imagen Molecular/tendencias , Medicina Nuclear/tendencias , Sociedades MédicasRESUMEN
UNLABELLED: The purpose of this study was to determine whether certain factors in the preparation and use of (99m)Tc-sulfur colloid affected the number of sentinel lymph nodes (SLNs) detected during SLN mapping and during intraoperative SLN identification. The factors that were investigated included the use of a dry heat block versus a hot water bath to heat the (99m)Tc-sulfur colloid bulk vial, amount of (99m)TcOH4(-) added to form the sulfur colloid particles, time between the unit dose calibration and the injection of the dose, and breast quadrant in which the injection occurred. METHODS: Data were collected retrospectively and quantitatively analyzed from images and reports of 488 patients with breast cancer who had undergone SLN mapping and intraoperative SLN identification from January 1, 2008, to June 30, 2011, inclusive. The dependent variables assessed were the number of SLNs visualized during lymphoscintigraphy, number of radioactive SLNs removed during surgery, and total number of lymph nodes removed intraoperatively. RESULTS: There was no significant difference in outcomes when comparing the amount of (99m)TcOH4(-) added during the preparation process to form the sulfur colloid particles, time between the unit dose calibration time and the time that the unit doses were injected, or location in the breast tissue in which the unit dose was administered. Initially, there were observed significant differences in outcomes when the heating methods used to prepare the (99m)Tc-sulfur colloid were compared. When the increased number of patients who were administered a calibrated unit dose activity of 74 MBq in the group using a dry heat block preparation method was taken into account, however, the findings were not significant. CONCLUSION: The use of a dry heat block versus a hot water bath to heat the (99m)Tc-sulfur colloid bulk vial, amount of (99m)TcOH4(-) added to form sulfur colloid particles, time between the unit dose calibration and the injection of the dose, and breast quadrant in which the injection occurred do not affect the number of SLNs detected during SLN mapping and during intraoperative SLN identification.
