The effect of dietary interventions or patterns on the cardiometabolic health of individuals treated with androgen deprivation therapy for prostate cancer: A systematic review.

Prostate cancer survivors treated with androgen deprivation therapy may be at increased risk of cardiovascular disease. Dietary recommendations for the prevention and/or management of cardiovascular disease for these individuals are lacking. This review synthesizes the evidence on the effect of dietary interventions on cardiometabolic biomarkers and cardiovascular disease risk in prostate cancer survivors receiving androgen deprivation therapy. A systematic review was conducted across PubMed, CINAHL, Embase, and Cochrane CENTRAL. Intervention or observational cohort studies evaluating diets, nutrients, or nutraceuticals with or without concurrent exercise interventions on cardiovascular disease, cardiovascular events, or cardiovascular disease biomarkers in those treated with androgen deprivation therapy were included. Confidence in the body of evidence was appraised using Grading of Recommendations, Assessment, Development and Evaluations. Twelve studies reported across fifteen papers were included. Interventions were heterogenous, with most studies including an exercise co-intervention (n = 8). Few significant findings for the effects of diet on cardiometabolic markers were likely due to weak methodology and sample sizes. Strongest evidence was for the effect of a healthy Western dietary pattern with exercise on improved blood pressure (Confidence: moderate). The healthy Western dietary pattern with exercise may improve high-density lipoprotein cholesterol (Confidence: Low) and flow-mediated dilation. Soy may improve total cholesterol (Confidence: Very low). A low-carbohydrate diet with physical activity may improve high-density lipoprotein cholesterol, incidence of metabolic syndrome, and Framingham cardiovascular disease risk score. Evidence of the effect of dietary interventions on cardiometabolic biomarkers and cardiovascular disease risk of prostate cancer survivors receiving androgen deprivation therapy is insufficient to inform practice. Well-designed dietary interventions aimed at improving cardiometabolic outcomes of this population are warranted to inform future dietary recommendations.

Skeletal muscle morphology in patients receiving primary versus interval cytoreductive surgery for advanced high-grade serous ovarian cancer.

OBJECTIVE: Our primary aim was to compare muscle morphology (skeletal muscle mass and density) between patients who underwent primary cytoreductive surgery versus interval cytoreductive surgery for advanced high-grade serous ovarian cancer. Secondarily, we explored the associations of muscle morphology with survival outcomes. METHODS: We retrospectively analysed computed tomography (CT) images for 88 ovarian cancer patients (aged 38-89 years) to calculate skeletal muscle index (cm2/m2) and skeletal muscle density (Hounsfield units (HU)). A skeletal muscle index of <38.5 cm2/m2 and skeletal muscle density of <33.7 HU were classified as low. Analyses included repeated measures analysis of covariance and multivariable Cox proportional hazards regression. RESULTS: At baseline, 44.3% of patients had low skeletal muscle index and 50.6% had low skeletal muscle density, with interval surgery patients having significantly lower mean skeletal muscle density than primary surgery patients (32.2±8.9 vs 37.3±8.6 HU, p=0.014). Although both groups had similar reductions in skeletal muscle index following treatment (p=0.49), primary surgery patients had a greater reduction in skeletal muscle density compared with interval surgery patients (-2.4 HU, 95% CI -4.3 to -0.5, p=0.016). Patients who experienced skeletal muscle density loss >2% during treatment (HR 5.16, 95% CI 1.33 to 20.02) and had low skeletal muscle density post-treatment (HR 58.87, 95% CI 3.70 to 935.68) had significantly worse overall survival. CONCLUSION: Low skeletal muscle index and skeletal muscle density were prevalent at ovarian cancer diagnosis. While both groups experienced muscle mass loss, greater reductions in skeletal muscle density occurred in patients undergoing primary surgery. In addition, skeletal muscle density loss during treatment and low skeletal muscle density post-treatment were associated with poorer overall survival. Supportive care involving resistance exercise targeting muscle hypertrophic drive, and nutrition counseling during and after ovarian cancer treatment may help preserve/enhance muscle mass and density.

Large Reductions in Match Play Physical Performance Variables Across a Professional Football Season With Control for Situational and Contextual Variables.

This investigation examined match play physical performance across a professional football season using a multicamera computerized tracking system. A linear mixed-effects model, controlling for situational and contextual variables, identified decreases in team average total distance (TD): season quarter 1 (Q1) (11,047 m) > season quarter 2 (Q2) (10,473 m) (P = 0.002; ES = Small), season quarter 3 (Q3) (10,449 m) (P < 0.001; ES = Moderate), and season quarter 4 (Q4) (10,385 m) (P < 0.001; ES = Moderate); work rate (WR): Q1 (115 m/min) > Q3 (108 m/min) (P < 0.001; ES = Moderate), Q4 (107 m/min) (P < 0.001; ES = Moderate); Q2 (109 m/min) > Q4 (107 m/min) (P = 0.003; ES = Small); high-speed running distance (HSR): Q1 (1,051 m) > Q2 (813 m) (P = 0.006; ES = Small); number of high-speed runs (NHSR): Q1 (87) > Q2 (65) (P < 0.001; ES = Small), Q3 (64) (P = 0.002; ES = Small); sprint distance (SD): Q1 (202 m) > Q4 (130 m) (P < 0.001; ES = Moderate), Q2 (179 m) > Q3 (165 m) (P = 0.035; ES = Small), Q4 (130 m) (P < 0.001; ES = Moderate) and number of sprints (NS): Q1 (20.4) > Q3 (10.2) (P < 0.001; ES = Moderate), Q4 (8.3) (P < 0.001; ES = Large); Q2 (14.9) > Q3 (10.2) (P < 0.001; ES = Moderate), Q4 (8.3) (P < 0.001; ES = Large). Within-position changes were observed for WR: Q1 (122 m/min) > Q4 (113 m/min) (P = 0.002; ES = Large) in central midfielders and for NS: Q1 > Q3 in wide defenders (21.7 vs. 10.8) (P = 0.044; ES = Large) and central midfielders (18.1 vs. 8.3) (P = 0.002; ES = Large); Q1 > Q4 in central defenders (13.1 vs. 5.3) (P = 0.014; ES = Large), wide defenders (21.6 vs. 7.1) (P < 0.001; ES = Very Large), central midfielders (18.1 vs. 8.5) (P = 0.005; ES = Large), and wide midfielders (20.8 vs. 12.2) (P = 0.012; ES = Large); Q2 > Q3 in central midfielders (16.9 vs. 8.3) (P = 0.002; ES = Large) and Q2 > Q4 in wide defenders (16.3 vs. 7.1) (P = 0.005; ES = Very Large), central midfielders (16.9 vs. 8.5) (P = 0.004; ES = Large), and wide midfielders (20.8 vs. 12.2) (P = 0.007; ES = Large). The match-play physical performance was reduced across the competitive season. The most notable reductions were observed in wide defenders, central midfielders, and wide midfielders in sprint performance indices.

A comparison of the kinematics, kinetics and muscle activity between pneumatic and free weight resistance.

Pneumatic devices provide a resistance comprising minimal mass, possibly affording greater movement velocities, compared to free weight, while reducing the influence of momentum. Thirty men completed three testing sessions [free weight (FW), ballistic (BALL) and pneumatic (P)] each consisting of a one repetition maximum (1RM) and six sets (15, 30, 45, 60, 75 and 90% 1RM) of four explosive repetitions of a bench press. Dependent variables were expressed as mean and as a percentage of the concentric displacement. Significant differences (P < 0.05) were evaluated using two way repeated measures ANOVAs with Holm-Sidak post hoc comparisons. On average, the mean and peak P velocity were 36.5 and 28.3% higher than FW, and 22.9 and 19.1% higher than the BALL movements. The FW and BALL peak force were both significantly higher than the P (26.3 and 22.7% for FW and BALL, respectively). BALL mean power output was significantly higher than the FW and P at loads of 15 and 30% 1RM; however, between loads of 60-90% 1RM the highest mean power was produced with a P resistance. A 15% 1RM load maximized the peak power for each condition and no significant differences were found between the P and BALL. For loads of 45-90% 1RM the force, power and muscle activity were higher during the last 10-20% of the concentric displacement when subjects employed the P resistance. In summary, pneumatic resistance may offer specific advantages over loads comprising only mass (FW and BALL), although not without its own limitations.