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1.
Sci Rep ; 13(1): 13082, 2023 08 11.
Artículo en Inglés | MEDLINE | ID: mdl-37567888

RESUMEN

In recent years, COVID-19 has evolved into many variants, posing new challenges for disease control and prevention. The Omicron variant, in particular, has been found to be highly contagious. In this study, we constructed and analyzed a mathematical model of COVID-19 transmission that incorporates vaccination and three different compartments of the infected population: asymptomatic [Formula: see text], symptomatic [Formula: see text], and Omicron [Formula: see text]. The model is formulated in the Caputo sense, which allows for fractional derivatives that capture the memory effects of the disease dynamics. We proved the existence and uniqueness of the solution of the model, obtained the effective reproduction number, showed that the model exhibits both endemic and disease-free equilibrium points, and showed that backward bifurcation can occur. Furthermore, we documented the effects of asymptomatic infected individuals on the disease transmission. We validated the model using real data from Thailand and found that vaccination alone is insufficient to completely eradicate the disease. We also found that Thailand must monitor asymptomatic individuals through stringent testing to halt and subsequently eradicate the disease. Our study provides novel insights into the behavior and impact of the Omicron variant and suggests possible strategies to mitigate its spread.


Asunto(s)
COVID-19 , Conceptos Matemáticos , Humanos , Tailandia/epidemiología , Modelos Biológicos , Simulación por Computador , COVID-19/epidemiología , COVID-19/prevención & control , SARS-CoV-2
2.
Math Biosci Eng ; 19(12): 12279-12302, 2022 Aug 22.
Artículo en Inglés | MEDLINE | ID: mdl-36653997

RESUMEN

This article explores the equilibrium configurations of a cantilever beam described by the minimizer of a generalized total energy functional. We reformulate the problem as a boundary value problem using the Euler-Lagrange condition and investigate the existence and uniqueness of minimizers. Furthermore, we discuss the dependence of solutions on the parameters of the boundary value problems. In addition, the Adomian decomposition method is derived for approximating the solution in terms of series. Finally, numerical results for the equilibrium configurations of cantilever beams are presented to support our theoretical analysis.

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