1.
Eur J Med Chem
; 89: 21-31, 2015 Jan 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25462222
RESUMEN
Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR cancer cell lines. Regio-isomeric imidazo[4,5-b]pyridine analogues were synthesized and evaluated for their cytotoxic activity against a range of cancer cell lines. The structure-activity relationship (SAR) studies of the imidazopyridine analogues are also described. Analogue 6b displayed strong cytotoxicity and good microsomal stability.