RESUMEN
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.
Asunto(s)
Antibacterianos/uso terapéutico , COVID-19/complicaciones , Activación de Linfocitos , Neumonía Asociada al Ventilador/tratamiento farmacológico , Infecciones por Pseudomonas/tratamiento farmacológico , SARS-CoV-2 , Linfocitos T/inmunología , Antibacterianos/farmacología , COVID-19/inmunología , COVID-19/terapia , Farmacorresistencia Bacteriana Múltiple , Humanos , Pulmón/microbiología , Masculino , Meropenem/farmacología , Meropenem/uso terapéutico , Metagenómica , Persona de Mediana Edad , Combinación Piperacilina y Tazobactam/farmacología , Combinación Piperacilina y Tazobactam/uso terapéutico , Neumonía Asociada al Ventilador/diagnóstico por imagen , Neumonía Asociada al Ventilador/etiología , Infecciones por Pseudomonas/diagnóstico por imagen , Infecciones por Pseudomonas/etiología , Pseudomonas aeruginosa/aislamiento & purificación , Recurrencia , Respiración ArtificialRESUMEN
Many research facility managers, veterinarians and directors are familiar with the principles of Good Laboratory Practice, requirements of the Association for Assessment and Accreditation of Laboratory Animal Care International, tenets of biosecurity and standards of animal welfare and housing but may be less familiar with the ideas of business continuity. But business continuity considerations are as applicable to research facilities as they are to other institutions. The authors discuss how business continuity principles can be applied in the research context and propose that such application, or 'research continuity management,' enables a focused but wide-reaching approach to disaster preparedness.