Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing.

Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors mainly requires transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection, reduces biocompatibility, or limits portability. Here, we develop a set of millimeter-scale, chip-less, and battery-less magnetic implants paired with a fully integrated wearable device for measuring biophysical and biochemical signals. The wearable device can induce a large amplitude damped vibration of the magnetic implants and capture their subsequent motions wirelessly. These motions reflect the biophysical conditions surrounding the implants and the concentration of a specific biochemical depending on the surface modification. Experiments in rat models demonstrate the capabilities of measuring cerebrospinal fluid (CSF) viscosity, intracranial pressure, and CSF glucose levels. This miniaturized system opens the possibility for continuous, wireless monitoring of a wide range of biophysical and biochemical conditions within the living organism.

Spatial differentiation and geographical similarity of traditional villages--Take the Yellow River Basin and the Yangtze River Basin as examples.

The preservation and advancement of Traditional Villages are intricately linked to the perpetuation of cultural heritage. However, existing research on the spatial disparities among Traditional Villages has yet to consider the impact of cultural factors. Moreover, the geographical similarities shared by Traditional Villages have not been thoroughly examined. Therefore, this study takes the Yellow River Basin and the Yangtze River Basin, both pivotal in the genesis of Chinese culture, as case studies. We employ an Optimal Parameter-based GeoDetector alongside the Spatially Constrained Multivariate Clustering method to delve into the factors influencing the spatial differentiation and geographical similarities of Traditional Villages within these two significant river basins. Subsequently, we offer recommendations for fostering the sustainable preservation and development of Traditional Villages in these regions. The results indicate that the Rural Residents Per Capita Disposable Income has the greatest impact on the spatial differentiation of Traditional Villages in the Yellow River Basin, while the Density of National Intangible Cultural Heritage Inheritors has the most significant influence in the Yangtze River Basin. The interaction effects of the driving factors are more powerful, with a q-value of 0.9544 for the interplay between the Density of National Cultural Protection Units and the Tourism Income in the Yellow River Basin and a value of 0.9099 for the interaction between the Density of National Intangible Cultural Heritage Inheritors and the Transportation in the Yangtze River Basin. Regarding geographical similarity, the Traditional Villages in the Yellow River Basin are divided into three major clusters, while those in the Yangtze River Basin are divided into two.

Acupuncture Enhances Signals at Sensitized Acupoints to Elevate Pressure Pain Threshold in Knee Osteoarthritis Patients.

OBJECTIVE: To observe the pressure pain threshold (PPT), skin conductance (SC) and blood perfusion (BP) of the sensitized acupoints in patients with knee osteoarthritis (KOA), and explore the mechanism of acupuncture at the sensitized acupoints for treating diseases. METHODS: Eleven healthy subjects and 11 unilateral KOA patients were recruited from July 2020 to March 2021 in this study. The PPT, SC and BP of control acupoints in healthy controls, and non-sensitized and sensitized acupoints in KOA patients were measured and compared between baseline and after manual acupuncture (MA) treatment. RESULTS: Before MA treatment, lower PPT was observed at the sensitized acupoints compared with non-sensitized and control acupoints (P<0.05). After MA treatment, PPT at the sensitized acupoints increased significantly in KOA patients (P<0.05). Before MA treatment, there was no statistical difference in SC and BP among control, non-sensitized and sensitized acupoints (P>0.05). Compared with the control and non-sensitized acupoints, there were significant increases of SC and BP in sensitized acupoints of KOA patients after MA treatment (P<0.05 or P<0.01). CONCLUSION: MA at sensitized acupoints could elevate PPT of KOA patients, which may be associated with the increment of SC and BP.

Mechanically Active Materials and Devices for Bio-Interfaced Pressure Sensors-A Review.

Pressures generated by external forces or by internal body processes represent parameters of critical importance in diagnosing physiological health and in anticipating injuries. Examples span intracranial hypertension from traumatic brain injuries, high blood pressure from poor diet, pressure-induced skin ulcers from immobility, and edema from congestive heart failure. Pressures measured on the soft surfaces of vital organs or within internal cavities of the body can provide essential insights into patient status and progression. Challenges lie in the development of high-performance pressure sensors that can softly interface with biological tissues to enable safe monitoring for extended periods of time. This review focuses on recent advances in mechanically active materials and structural designs for classes of soft pressure sensors that have proven uses in these contexts. The discussions include applications of such sensors as implantable and wearable systems, with various unique capabilities in wireless continuous monitoring, minimally invasive deployment, natural degradation in biofluids, and/or multiplexed spatiotemporal mapping. A concluding section summarizes challenges and future opportunities for this growing field of materials and biomedical research.