Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain.

BACKGROUND: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain. METHODS: We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests. RESULTS: From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4 cell counts (204 cells/µl), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02_AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Median CD4 cell counts reached up to 418 cells/µl. CONCLUSION: Roughly 9% of individuals with HIV-2 infection living in Spain are coinfected with HIV-1. Overall, 70% of dually infected patients achieved viral suppression for both viruses under antiretroviral therapy. Given the relatively large population of West Africans living in Spain and the continuous migration flow from HIV-2 endemic areas, HIV-1/HIV-2 coinfection should always be excluded at first diagnosis in all HIV-seroreactive persons.

Prevalencia de estrés en estudiantado universitario del Grado en Enfermería en la provincia de Lugo / Prevalence of stress among University Nursing students in the province of Lugo

OBJETIVO: determinar la prevalencia de la sintomatología de estrés en el alumnado universitario del Grado en Enfermería en la provincia de Lugo. MÉTODO: estudio descriptivo realizado en 2016. La población de estudio fueron alumnos de primero, segundo y tercero de Grado de Enfermería de la Escuela Universitaria de Enfermería de Lugo. Se utilizó el Cuestionario de Cambios de Vida Recientes (CCVR), que consta de 74 ítems que valoran una lista de sucesos vitales clasificadosen cinco ámbitos: salud, trabajo, casa y familia, personal y social y finanzas.Se considera nivel de estrés bajo si se computa un valor menor a 150, intermedio entre 150-300 y elevado si fuera superior a 300. Se realizó análisis descriptivo con media y desviación estándar (DE). Se utilizó el programa estadístico SPSS versión 24. RESULTADOS: se recogieron 118 cuestionarios. La media (DE) de edad de los participantes fue de 21,5 (4,7) años. La puntuación media (DE) de CCVR fue de 239,9 (150). Para el primer curso la puntuación media (DE) fue de 197,5 (92,847). Para el segundo curso se situó en 233 (155,17). Para el tercer curso fue de 276,31 (170,82). Del total de la muestra se ha considerado estrés bajo al 33,1% (n= 39), estrés intermedio al 38,1% (n= 45) y estrés elevado al 28,8% (n= 34). CONCLUSIONES: se ha registrado que un tercio del estudiantado de los tres primeros cursos del Grado en Enfermería de la provincia de Lugo presenta sintomatología de estrés

OBJECTIVE: to determine the prevalence of stress symptomatology among the University Nursing students in the province of Lugo. METHOD: a descriptive study conducted in 2016. The study population were students from the first,second and third year of Nursing at the University School of Nursing in Lugo. The Recent Life Changes Questionnaire (RLCQ) was used; it includes 74 items assessing a list of life events classifiedinto fivesettings: health, work, home and family, personal and social, and finances. The level of stress is considered to be low with a value < 150, intermediate between 150 and 300, and high if > 300. Descriptive analysis was conducted with mean and standard deviation (SD). The SPSS version 24 statistical program was used. RESULTS: in total, 118 questionnaires were collected. The mean (SD) age of participants was 21.5 (4.7) years. The mean score (SD) in the RLCQ was 239.9 (150). For the first year, the mean score (SD) was 197.5 (92.847); for the second year, it was 233 (155.17); and for the third year in the degree, it was 276.31 (170.82). Of the overall sample, 33.1% (n= 39) were considered to present low stress, 38.1% (n= 45) had intermediate stress, and 28.8% (n= 34) presented a high level of stress. CONCLUSIONS: it has been recorded that a third of the students from the first three years of the Nursing Degree at the province of Lugo present stress symptomatology