RESUMEN
We analyzed interrelations between the cerebral blood flow, cardiac output, and condition of the brain substance in 530 patients with ischemic stroke. Dependencies between the linear blood flow velocities in all arteries supplying the brain, as well as between the total volume blood flow through the internal carotid arteries and left ventricular stroke volume were revealed. The severity of atrophy was maximum in the parietal lobes (median 1.5 (1.0; 2.0)) and minimum in the occipital lobes (median 0.5 (0; 1.0)). Temporal lobes cortical atrophy significantly correlated with changes in the limbic system and in the periventricular and deep white matter; a significant weak inverse correlation of this parameter with blood flow in the middle cerebral artery was also found. Changes in the periventricular white matter (but not in deep white matter) demonstrated a significant inverse correlation with blood flow in the middle and anterior cerebral arteries.
Asunto(s)
Circulación Cerebrovascular , Accidente Cerebrovascular Isquémico/fisiopatología , Lóbulo Occipital/fisiopatología , Lóbulo Temporal/fisiopatología , Sustancia Blanca/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Arteria Cerebral Anterior/diagnóstico por imagen , Arteria Cerebral Anterior/fisiopatología , Arteria Basilar/diagnóstico por imagen , Arteria Basilar/fisiopatología , Velocidad del Flujo Sanguíneo , Arteria Carótida Interna/diagnóstico por imagen , Arteria Carótida Interna/fisiopatología , Femenino , Humanos , Accidente Cerebrovascular Isquémico/diagnóstico por imagen , Sistema Límbico/diagnóstico por imagen , Sistema Límbico/fisiopatología , Angiografía por Resonancia Magnética , Masculino , Persona de Mediana Edad , Arteria Cerebral Media/diagnóstico por imagen , Arteria Cerebral Media/fisiopatología , Neuroimagen , Lóbulo Occipital/diagnóstico por imagen , Arteria Cerebral Posterior/diagnóstico por imagen , Arteria Cerebral Posterior/fisiopatología , Estudios Prospectivos , Volumen Sistólico , Lóbulo Temporal/diagnóstico por imagen , Arteria Vertebral/diagnóstico por imagen , Arteria Vertebral/fisiopatología , Sustancia Blanca/diagnóstico por imagenRESUMEN
We analyzed the relationship between white matter hyperintensities in T2-weighted MR-images (according to Fazekas score) and the state of cognitive functions (total MOCA score) in 65 asymptomatic individuals. A relationship between the presence/number of lesions in the deep white matter of the brain and cognitive status according to the total MOCA score was revealed. The results of cognitive functions assessment also correlated with MRI evaluation of the severity of brain cortex atrophy. The severity of deep white matter lesions according to the Fazekas scale were also associated with end-diastolic blood flow velocities in the middle cerebral, vertebral, and basilar arteries.
