RESUMEN
The objective of the present work was to elaborate the content of comprehensive psycho-pedagogical examination for the assessment of the overall intelligence level in the children presenting with hearing impairments. The complex of studies to be carried out to achieve this purpose encompasses evaluation of the social, physical, and cognitive development of the children as well as peculiarities of their play activities, their speech and hearing abilities. This approach is believed to enable a teacher of deaf and hard of hearing to identify the individual characteristics of each child and determine those of special importance for the elaboration of educational programs on an individual basis taking into consideration variants of children's development (harmonic, uneven, retarded, etc.). To facilitate the implementation of the proposed method, a special electronic tool (a virtual practice for a teacher of deaf) has been created. The virtual practice is believed to be instrumental in the training of the teachers of deaf for the comprehensive evaluation of the children with cochlear implants. In this way, the effectiveness of the development of personalized rehabilitation programs can be substantially increased.
Asunto(s)
Implantación Coclear/rehabilitación , Corrección de Deficiencia Auditiva , Pérdida Auditiva , Desarrollo Infantil , Preescolar , Implantación Coclear/métodos , Corrección de Deficiencia Auditiva/métodos , Corrección de Deficiencia Auditiva/psicología , Intervención Educativa Precoz/métodos , Pérdida Auditiva/diagnóstico , Pérdida Auditiva/psicología , Pérdida Auditiva/cirugía , Humanos , Relaciones Profesional-Paciente , Resultado del TratamientoRESUMEN
The toxicity of the picrotoxin bicuculline, but not of 3-mercaptopropionic acid increased in mice pretreated with triorthocresyl phosphate (TOCP). TOCP decreased the affinity of brain GABA receptors of intact mice for [3H] GABA. The binding of [3H]-t-butylcycloorthobenzoate was unchanged. The increased toxicity of GABA-antagonists may be associated with inhibition of blood carboxylesterases. The possibility of direct influence of TOCP and its metabolites on the GABA/benzodiazepine receptor complex cannot be excluded.
Asunto(s)
Compuestos Bicíclicos Heterocíclicos con Puentes , Antagonistas del GABA , Tritolilfosfatos/farmacología , Ácido gamma-Aminobutírico/efectos de los fármacos , Ácido 3-Mercaptopropiónico/toxicidad , Animales , Bicuculina/toxicidad , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Compuestos Bicíclicos con Puentes/metabolismo , Hidrolasas de Éster Carboxílico/sangre , Hidrolasas de Éster Carboxílico/efectos de los fármacos , Interacciones Farmacológicas , Técnicas In Vitro , Ligandos , Masculino , Ratones , Picrotoxina/toxicidad , Membranas Sinápticas/efectos de los fármacos , Membranas Sinápticas/metabolismo , Ácido gamma-Aminobutírico/metabolismoRESUMEN
The binding of [3H] quinuclidinyl benzilate (QNB) to rat striatum membranes after diisopropylfluorophosphate (DFP) induced seizures was characterized. There was a 36% decrease in Kd and a 33% decrease in the number of muscarinic receptors. Paraoxon caused inhibition fo [3H] QNB binding to the striatal membranes of intact rats. It is possible that a direct action of DFP on the muscarinic receptor is not the cause of anti-cholinesterase-induced changes in [3H] QNB binding.