[The pedagogical evaluation of the pre-school children with cochlear implants]. / Pedagogicheskoe obsledovanie detei doshkol'nogo vozrasta s kokhlearnymi implantami.

The objective of the present work was to elaborate the content of comprehensive psycho-pedagogical examination for the assessment of the overall intelligence level in the children presenting with hearing impairments. The complex of studies to be carried out to achieve this purpose encompasses evaluation of the social, physical, and cognitive development of the children as well as peculiarities of their play activities, their speech and hearing abilities. This approach is believed to enable a teacher of deaf and hard of hearing to identify the individual characteristics of each child and determine those of special importance for the elaboration of educational programs on an individual basis taking into consideration variants of children's development (harmonic, uneven, retarded, etc.). To facilitate the implementation of the proposed method, a special electronic tool (a virtual practice for a teacher of deaf) has been created. The virtual practice is believed to be instrumental in the training of the teachers of deaf for the comprehensive evaluation of the children with cochlear implants. In this way, the effectiveness of the development of personalized rehabilitation programs can be substantially increased.

[The effect of triorthocresyl phosphate on the toxicity of GABA-lytics for mice]. / Vliianie triortokrezilfosfata na toksichnost' GAMK-litikov dlia myshei.

The toxicity of the picrotoxin bicuculline, but not of 3-mercaptopropionic acid increased in mice pretreated with triorthocresyl phosphate (TOCP). TOCP decreased the affinity of brain GABA receptors of intact mice for [3H] GABA. The binding of [3H]-t-butylcycloorthobenzoate was unchanged. The increased toxicity of GABA-antagonists may be associated with inhibition of blood carboxylesterases. The possibility of direct influence of TOCP and its metabolites on the GABA/benzodiazepine receptor complex cannot be excluded.

[Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes]. / Vliianie diizopropilftorfosfata, paraoksona i dikhlofosa na sviazyvanie [3H] khinuklidinil benzilata s sinapticheskimi membranami striatuma krys.

The binding of [3H] quinuclidinyl benzilate (QNB) to rat striatum membranes after diisopropylfluorophosphate (DFP) induced seizures was characterized. There was a 36% decrease in Kd and a 33% decrease in the number of muscarinic receptors. Paraoxon caused inhibition fo [3H] QNB binding to the striatal membranes of intact rats. It is possible that a direct action of DFP on the muscarinic receptor is not the cause of anti-cholinesterase-induced changes in [3H] QNB binding.