1.
Eur Cytokine Netw
; 11(3): 512-3, 2000 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11203199
Asunto(s)
Interleucina-6/fisiología , Transducción de Señal/inmunología , Animales , Citocinas/fisiología , Proteínas de Unión al ADN/metabolismo , Regulación de la Expresión Génica , Humanos , Proteínas Quinasas Activadas por Mitógenos/metabolismo , Factor de Transcripción STAT1 , Factor de Transcripción STAT3 , Transactivadores/metabolismo
2.
FEBS Lett
; 463(3): 365-70, 1999 Dec 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10606755
RESUMEN
Recent findings indicate that cytokine signaling can be modulated by other mediators of simultaneously activated signal transduction pathways. In this study we show that LPS and TNFalpha are potent inhibitors of IL-6-mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. Accordingly, LPS and TNFalpha were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFalpha.