[Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation].

OBJECTIVE: To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation. METHOD: The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed. RESULT: The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%. CONCLUSION: The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.