A preliminary study of the diagnostic efficacy and safety of the novel boring biopsy for brain lesions.

Existing methods for biopsy of intraparenchymal brain lesions, including stereotactic biopsy and open block biopsy, have advantages and disadvantages. We propose a novel biopsy method, called "boring biopsy," which aims to overcome the drawbacks of each conventional method. This method is less invasive and allows obtaining continuous specimens of sufficient volume. We aimed to assess the feasibility and efficacy of using boring biopsy for intraparenchymal brain lesions. We included 26 consecutive patients who underwent boring biopsy for intraparenchymal lesions. Columnar continuous specimens from the surface of the normal brain tissue to the tumor margin and the center of the lesion were obtained using the boring biopsy method. We used a catheter introducer with original modifications to create a cylindrical biopsy tool for surgery. Columnar continuous specimens were successfully obtained. Histopathological diagnosis was based on cellular changes and differentiation from normal tissues to the core of the lesion and established in all cases. No permanent deficits, major adverse outcomes, or deaths were observed. This novel technique may improve diagnostic accuracy and reduce invasiveness associated with brain biopsy. This method may become the next standard procedure, particularly in some cases where histological evaluation is paramount, and conventional biopsy methods are not suitable.

[Optic neuropathy from connected intra- and extraorbital lesions in IgG4-related disease].

We present the case of a 74-year-old woman complaining of blurred vision in the left eye who was found to have a unilateral, continuous lesion of the optic nerve and nerve sheath accompanied by an intracranial mass next to the cavernous sinus and meninges. Surgical decompression of the left optic nerve in the optic canal and partial resection of the mass followed by prednisolone administration were successful. Immunohistochemical analysis disclosed abundant infiltration of IgG4-positive plasma cells at >10 cells/high power field. These findings indicated a new pattern of compressive optic neuropathy with confirmed IgG4 histopathological findings. Such an extensive lesion may produce visual disturbance.

Intraoperative Test Occlusion as Adjustment of Extracranial-to-Intracranial Bypass Strategy for Unclippable Giant Aneurysm of the Internal Carotid Artery.

BACKGROUND: There is still a controversy for low-flow extracranial-intracranial or high-flow extracranial-intracranial bypass with proximal occlusion in the treatment of unclippable giant internal carotid artery aneurysms. CASE DESCRIPTION: A 61-year-old woman presented with a 1-month history of double vision. Neuroimages revealed an unclippable giant internal carotid artery aneurysm located from the cavernous sinus to proximal site of the posterior communicating artery. Ipsilateral A1 of the anterior cerebral artery was hypoplastic, and posterior communicating artery was patent. Intraoperative proximal test occlusion at cervical internal carotid artery under neurophysiological monitoring, instead of preoperative balloon test occlusion, was performed to assess whether low-flow bypass was sufficient. The monitoring was unchanged during test occlusion, and the aneurysm was successfully trapped without high-flow bypass. Neither ischemic lesion nor neurologic deficits were found postoperatively. CONCLUSIONS: Intraoperative proximal test occlusion is useful to decide on the surgical procedure of revascularization in patients with unclippable internal carotid aneurysm.

Single-channel 7.68 Tbit/s, 64 QAM coherent Nyquist pulse transmission over 150 km with a spectral efficiency of 9.7 bit/s/Hz.

We achieved a record capacity of 7.68 Tbit/s in a single-channel OTDM transmission with a 9.7 bit/s/Hz spectral efficiency, where a polarization-multiplexed 640 Gbaud, 64 QAM coherent Nyquist pulse has been transmitted over 150 km. In this scheme, a 1.39 ps optical Nyquist pulse with an OSNR of 53 dB at a 0.1 nm resolution was generated by combining a mode-locked laser and a highly nonlinear fiber and used at both the transmitter and receiver. Phase synchronization was achieved between these pulse sources with an advanced optical phase-locked loop based on the higher harmonics of the mode-locked laser mode. In addition, we suppressed a nonlinear phase rotation at an EDFA in the transmitter by broadening the pulse width with second-order dispersion and recompressed it to the original pulse width before a 150 km transmission link. We succeeded in a bit error rate below 2 x 10-2 for all tributaries.

Single-channel 3.84 Tbit/s, 64 QAM coherent Nyquist pulse transmission over 150 km with a spectral efficiency of 10.6 bit/s/Hz.

We report a polarization-multiplexed 320 Gbaud, 64 QAM coherent Nyquist pulse transmission with a frequency-stabilized mode-locked laser and a modified digital back-propagation method for pulse transmission. Using a combination consisting of a mode-locked laser and a pulse shaper, we obtained a Nyquist pulse with a high OSNR of 51 dB. We achieved error free operation under a back-to-back condition with the OSNR improvement. By developing a new digital back-propagation method for pulse propagation, we achieved a bit error rate below the 7% forward error correction limit of 2x10-3 for all the tributaries of the OTDM signal data after a 150 km transmission. As a result, single-channel 3.84 Tbit/s data were successfully transmitted over 150 km with a spectral efficiency of 10.6 bit/s/Hz.

Open Embolectomy of Large Vessel Occlusion in the Endovascular Era: Results of a 12-Year Single-Center Experience.

BACKGROUND: Mechanical endovascular embolectomy using stent retrievers has gained popularity for treatment of large vessel occlusion in acute ischemic stroke. Use of open embolectomy as a direct surgical treatment has been limited, likely owing to the technical difficulty, therapeutic time window, and time-consuming procedure. METHODS: We retrospectively reviewed clinical and radiographic records of patients who underwent open embolectomy for major artery occlusion at an acute stage. Clinical features, complications, and outcome of patients were analyzed. RESULTS: From January 2004 to September 2016, 153 patients underwent 157 open embolectomies for major artery occlusion. Complete recanalization was achieved in 96.2% of patients. A favorable outcome was observed in 43.9%. Cerebral aneurysm along the occluded artery was observed in 11 patients with 12 aneurysms. CONCLUSIONS: Open embolectomy resulted in a high complete recanalization rate with an acceptable safety profile. Open embolectomy is a safe and durable method of cerebral recanalization in patients with embolic stroke and can be considered as a potential treatment if endovascular embolectomy cannot be performed. The details of the occluded arteries presented here will be useful for endovascular surgeons to prevent complications.

Emergency EC-IC bypass for symptomatic atherosclerotic ischemic stroke.

Previous studies have shown that extracranial-intracranial (EC-IC) bypass surgery has no preventive effect on subsequent ipsilateral ischemic stroke in patients with symptomatic atherosclerotic internal carotid occlusion and hemodynamic cerebral ischemia. A few studies have assessed whether an urgent EC-IC bypass surgery is an effective treatment for main trunk stenosis or occlusion in acute stage. The authors retrospectively reviewed 58 consecutive patients who underwent urgent EC-IC bypass for symptomatic internal carotid artery or the middle cerebral artery stenosis or occlusion between January 2003 and December 2011. Clinical characteristics and neuroimagings were evaluated and analyzed. Based on preoperative angiogram, responsible lesions were the internal carotid artery in 19 (32.8%) patients and the middle cerebral artery in 39 (67.2%). No hemorrhagic complication occurred. Sixty-nine percent of patients showed improvement of neurological function after surgery, and 74.1% of patients had favorable outcome. Unfavorable outcome was associated with insufficient collateral flow and new infarction after bypass surgery.

Mattress anastomosis in micro vascular reconstruction: technical note.

BACKGROUND: Superficial temporal artery-to-middle cerebral artery (STA-MCA) anastomosis is a common procedure for neurosurgeons. The surgery necessarily requires accurate and speedy manipulation of microscope, for which a specific training is needed. Unexpected bypass occlusion sometimes happen during surgery. OBJECTIVE: Generally, conventional interrupted or continuous suture has been used for vascular anastomosis, despite various ideas have been attempted in the other surgery fields. We propose a horizontal mattress suture technique for intracranial microvascular bypass surgery. This is the first report ever published on intracranial vascular anastomosis. METHODS: We had four patients of STA-MCA bypass surgery with "mattress anastomosis" from March to May of 2012. RESULTS: During the procedure, there was no bypass occlusion and good patency was confirmed in all cases. CONCLUSION: Intimae of the recipient and the donor blood vessel contact each other precisely with this technique. Although a long-term assessment of patency is needed, it is useful for the intracranial bypass surgery.

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

BACKGROUND: The authors report a rare case of a patient with previously treated cutaneous malignant melanoma that recurred 1 year later as an intracranial meningioma. CASE DESCRIPTION: A 20-year-old woman presented with exophthalmos, diplopia and a mass in the left supraorbital area. Imaging study revealed an enhanced intracranial extradural mass with bone destruction. The patient had a history of cutaneous malignant melanoma surgery on the same location 1 year before. The patient underwent left frontotemporal craniotomy for total resection of the mass. Histological study revealed the intracranial mass to be an atypical meningioma. CONCLUSION: To our knowledge, this is a rare report of a patient with this tumor occurrence. This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

Urgent open embolectomy for cardioembolic cervical internal carotid artery occlusion.

Acute ischemic stroke attributable to cervical internal carotid artery (ICA) occlusion is frequently associated with severe disability or death and is usually caused by atherosclerosis. By contrast, the cardioembolic cervical ICA occlusion is rare, and feasibility of urgent recanalization remains unclear. We present the first study in the literature that focuses on urgent open embolectomy for the treatment of cardioembolic cervical ICA occlusion. A retrospective review of the charts for patients undergoing open embolectomy was performed. Between April 2006 and September 2007, 640 consecutive patients with acute ischemic stroke were treated. Of them, three patients (0.47%) with the acute complete cardioembolic cervical ICA occlusion underwent urgent open embolectomy. All patients presented with profound neurological deficits and atrial fibrillation. The urgent open embolectomy achieved complete recanalization in all patients without any complications. All emboli in three patients were very large and fibrinous in histological findings. Two of three patients showed rapid improvement in neurological functions after surgical treatments. The cardioembolic occlusion of the cervical ICA is rare, but its possibility should be considered in patients with acute ischemic stroke suffering profound neurological deficits and atrial fibrillation. Urgent open embolectomy may be a treatment option to obtain successful recanalization for cardioembolic cervical ICA occlusion and is recommended because it is technically easier and similar to carotid endarterectomy.

Outcome predictors of open embolectomy in middle cerebral artery occlusion.

OBJECTIVE: The purpose of this paper was to analyse the outcome of the patients with acute middle cerebral artery (MCA) occlusion treated by open embolectomy. METHODS: A clinical chart review was retrospectively conducted for 30 patients who had MCA occlusion and were treated with open embolectomy. According to the Glasgow Outcome Scale, the patients' outcome at discharge is divided in two groups: favorable outcome (good recovery and moderate disability) or unfavorable outcome (severe disability, vegetative state and death). The following variables between the favorable and unfavorable outcomes were analysed: age, sex, Glasgow Coma Scale score on admission, affected side, occlusion site, occlusion time, atrial fibrillation on electrocardiogram, fibrinolysis, aphasia, hemiparesis and hemorrhagic infarction after surgery. RESULTS: The outcomes of 30 patients were favorable in 16 patients (good recovery in nine and moderate disability in seven) and unfavorable in 14 patients (severe disability in 12, vegetative state in one and death in one). The M1 occlusion and fibrinolysis performance were more frequent in the unfavorable outcome group than in the favorable one. Logistic regression analysis with a stepwise method indicated that the only occlusion site was independently associated with the unfavorable outcome. The occlusion time >360 minutes was not the predictor of the unfavorable outcome. DISCUSSION: The outcome of patients with MCA occlusion treated by the open embolectomy depends on the occlusion site and the fibrinolysis performance in the present study. The M1 occlusion is also the independent risk factor of the unfavorable outcome. However, the occlusion time itself has no relation to the unfavorable outcome. These results indicate that therapeutic time windows vary in individuals probably due to the collateral blood flow.

Horizontal contralateral approach for the distal anterior cerebral artery aneurysm: technical note.

BACKGROUND: The authors present a modified interhemispheric approach for the distal ACA aneurysm to resolve several problems including the narrow surgical corridor, the difficulty of proximal control, and the aneurysmal projection toward the surgeon. METHODS: We refined the positions of the patient's head and the surgeon. The patient's head is fixed with flexion and tilted to the contralateral side. The surgeon sits on the contralateral side of the patient and not on the cranial side. RESULTS: The present approach allows the surgeon to comfortably use both hands in the horizontal operative filed, to obtain a minimum retraction of the brain, and to easily secure the proximal artery. CONCLUSIONS: This modified interhemispheric approach is useful for a patient with the distal ACA aneurysm.

Intraoperative angiography through the occipital artery and muscular branch of the vertebral artery: technical note.

BACKGROUND: Intraoperative cerebral angiography has been known as a useful tool for diagnosing neurovascular diseases. There are few reports of intraoperative angiography in the prone position. Intraoperative angiograms through the occipital artery and muscular branch of the vertebral artery have not also previously been described. METHODS: The occipital artery or muscular branch of the vertebral artery was used for the intraoperative cerebral angiography. With retrograde catheterization of these arteries, the contrast medium (5 to 10 mL) was manually injected by a surgeon. RESULTS: Adequate angiograms were obtained with this method. No complications occurred with this procedure. CONCLUSIONS: Intraoperative angiography through these arteries is useful, with good efficacy and safety, for a patient in the prone position.

Emergency revascularization for acute main-trunk occlusion in the anterior circulation.

We report the surgical results in patients with acute cerebral main-trunk occlusion in the anterior circulation. Between April 2004 and March 2005, 26 patients were surgically treated within 24h after the onset. The occlusion occurred in the internal carotid artery in 10 patients, in the middle cerebral artery in 15, and in the anterior cerebral artery in 1. We investigated the clinical characteristics and surgical treatment and evaluated the outcome using the modified Rankin Scale (mRS). Nine patients underwent anastomosis, 14 had an embolectomy, and 3 had a carotid endarterectomy. In all the patients, revascularization was achieved, and neurological improvement was obtained. At 6 months after the onset, eight (30.8%) patients showed a good recovery (defined as grade 1 on the mRS), seven (26.9%) were rated as grade 2, eight (30.8%) were grade 3, and three (11.5%) were grade 4. Manual muscle test on admission was significantly different between the good outcome and the poor outcome groups at 6 months after onset. None of the patients experienced any complications related to the surgery. Early surgical revascularization can be an effective and safe treatment modality in appropriately selected patients with acute cerebral main-trunk occlusion in the anterior circulation.

Emergency embolectomy for treatment of acute middle cerebral artery occlusion.

OBJECT: The authors evaluated the efficacy of emergency embolectomy in patients with acute middle cerebral artery occlusion (MCAO). METHODS: A retrospective review of the charts for patients undergoing embolectomy at the authors' institution was performed. Between October 1997 and May 2004, 12 patients (mean age 70 years) with acute MCAO were treated using embolectomy. Local intraarterial fibrinolysis with urokinase was initially undertaken in eight of 12 patients. Sufficient recanalization was not achieved with fibrinolysis in any patient, and thus embolectomy was performed immediately thereafter. Recanalization by embolectomy was achieved in all patients (mean occlusion time 6 hours, 11 minutes). Each patient's condition was evaluated on discharge. Outcomes in the 12 patients according to the Glasgow Outcome Scale were good recovery in five, moderate disability in two, severe disability in three, vegetative state in one, and death due to a cardiac complication in one. None of the 12 patients had symptomatic hemorrhagic infarction. CONCLUSIONS: Emergency embolectomy can be performed in patients with MCAO with minimal morbidity and death. The procedure can be used to achieve good recovery even in patients in whom fibrinolysis is insufficient after acute MCAO and should be a part of the algorithm for the treatment of MCAO.

Retraction suture technique for carotid endarterectomy.

We propose a retraction suture technique as a safe and effective surgical procedure for carotid endarterectomy. Retraction sutures of the skin flap, the carotid sheath and the adventitia of the carotid artery are used to obtain an adequate operative field without the use of retractors or assistants. This technique is useful for carotid endarterectomy.

Characteristics of distal posteroinferior cerebellar artery aneurysms.

OBJECTIVE: Distal posteroinferior cerebellar artery (PICA) aneurysms are rare and have not been well investigated previously. We report our series of 24 patients with 27 distal PICA aneurysms. METHODS: All patients with distal PICA aneurysms that were surgically treated at Shinshu University Hospital and its affiliated hospitals between 1983 and 2001 were reviewed retrospectively. Data relating to clinical, radiological, and intraoperative findings were analyzed. RESULTS: In our series, distal PICA aneurysms reached an incidence of 0.28 and 0.38% of all intracranial aneurysms and ruptured aneurysms, respectively. There were 23 ruptured and 4 unruptured distal PICA aneurysms. Of these, 74.1% were saccular, 7.4% fusiform, and 18.5% dissecting aneurysms. Primarily the telovelotonsillar segment of the PICA was affected. Usually, the surgical outcome was favorable and was influenced by the obstructive hydrocephalus and the preoperative grade. It was sometimes difficult to detect the ruptured distal PICA aneurysm on the initial angiogram, and an extracranial origin of the PICA was sometimes observed. CONCLUSION: This review summarizes the presentation and outcome of a large series of 24 patients with 27 distal PICA aneurysms, and we conclude that distal PICA aneurysms are benign entities compared with vertebral artery-PICA aneurysms. Characteristics that should be considered in the treatment of distal PICA aneurysms are discussed.

Double-insurance bypass for internal carotid artery aneurysm surgery.

OBJECTIVE: The aim of this article is to present the usefulness of a double-bypass method in the surgical treatment of complex internal carotid artery (ICA) aneurysms. For patients with clippable but complex aneurysms of the ICA having poor collateral circulation, bypass surgery is needed before temporary occlusion of the ICA. We propose a double bypass for safety. METHODS: The superficial temporal artery was anastomosed to the distal cortical branch of the middle cerebral artery (MCA), followed by anastomosis between the radial artery and the inferior trunk of the MCA. For patients with clippable ICA aneurysms, the radial artery was temporarily anastomosed to the inferior trunk of the MCA by raising the ipsilateral forearm to the head after the radial artery was harvested. After the aneurysm had been clipped, the anastomosed radial artery was cut close to the anastomosed site and repositioned back to the original arm. RESULTS: This double-bypass procedure was performed in two patients, and no ischemic complications related to revascularization were observed. Temporary occlusion times of the MCA for superficial temporal artery-to-MCA anastomosis and radial artery-to-MCA anastomosis were 30 and 46 minutes in one patient and 28 and 55 minutes in another. CONCLUSION: This surgical procedure, which we called "double-insurance bypass," can reduce the risk of ischemic complications associated with revascularization of the ICA.

[The efficacy of prophylactic administration of SBT/ABPC for postoperative infection in neurosurgical operations].

We investigated prospectively the efficacy of sulbactam sodium/ampicillin sodium (SBT/ABPC), which is a combination drug of ampicillin and beta-lactamase inhibitor, as a preventive drug against postoperative infection in the field of neurological surgery. One hundred and six patients were given SBT/ABPC as follows: Before anesthetic induction at surgery, 1.5 g of SBT/ABPC was administrated by intravenous drip infusion, and further doses were continued at 12-hour intervals for 5 to 7 days. We assessed postoperative infection, type of surgery, duration of operation, and amount of hemorrhage. Search for related side effects and bacteriological examinations of the nasal cavity and throat before and after treatment were performed. The result was that postoperative infection was found in none of the patients. Adverse reactions due to SBT/ABPC such as apparent skin symptoms or gastrointestinal symptoms were not observed. Considering infections highly resistant to MRSA, SBT/ABPC would be effective to prevent postoperative infection in neurosurgical operations and could be used safely.

Modified, multipurpose, radiolucent sugita head frame for intraoperative cerebral angiography.

OBJECTIVE: Although several radiolucent head-fixation devices have been developed to allow intraoperative cerebral angiography, no device provides satisfactory freedom to obtain the most suitable head position. We recently designed a multipurpose radiolucent Sugita head frame (modified radiolucent Sugita frame) with satisfactory degrees of freedom and rigidity for intraoperative head positioning and head holding, respectively. DESCRIPTION OF INSTRUMENTATION: A short arm and a ring joint, made of engineering plastic, were added to the prototype radiolucent Sugita frame, to permit side-tilting movements of the frame. The shape of all handles at the joints was also changed and the size was enlarged, to facilitate adjustment of the head position. EXPERIENCE AND RESULTS: We used this modified radiolucent Sugita frame in 20 cases involving aneurysms or arteriovenous malformations. The frame performed satisfactorily in all cases, in terms of firm head fixation and unrestrained freedom of head positioning at the surgeon's request. The modified radiolucent Sugita frame was evaluated with respect to its resistance to physical forces. The physical strength of the modified radiolucent Sugita frame is almost equivalent to that of the metallic Sugita frame and is considered sufficient for clinical usage. CONCLUSION: With its rigidity, satisfactory degrees of freedom, and ease of handling, the clinical applicability of the dramatically improved radiolucent head frame enables us to obtain satisfactory intraoperative angiograms.