1.
Bioorg Khim
; 40(2): 157-65, 2014.
Artículo
en Ruso
| MEDLINE
| ID: mdl-25895334
RESUMEN
A method of the synthesis of RGD peptide derivatives containing glutaric or adipic residues linked with α-amino group of L-arginine and allowing carrying out their coupling with other biomolecules and nanoparticles.
Asunto(s)
Adipatos/química , Arginina/química , Glutaratos/química , Oligopéptidos/síntesis química , Secuencia de Aminoácidos , Aminoácidos/química , Estructura Molecular , Oligopéptidos/química
2.
Amino Acids
; 22(2): 179-86, 2002.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12395185
RESUMEN
The paper describes the synthesis of ( 2S, 4S)-4-(N-Ts)- and ( 2S, 4S)-4-(N-Boc)-phenylamino-5-oxoprolines (pyroglutamic acid). These derivatives have been shown to be useful for synthesis of their amides and peptides in spite of steric hindrances caused by bulky groups adjacent to the reaction centre. Under the conditions applied no lactam ring opening and no loss of stereochemical integrity of any of the chiral centres were observed, which has been confirmed by NMR techniques.