Screening for primary aldosteronism in an argentinian population: a multicenter prospective study

Objectives Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.Subjects and methods We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.Results According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.Conclusion This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.

Screening for primary aldosteronism in an argentinian population: a multicenter prospective study.

OBJECTIVES: Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study. SUBJECTS AND METHODS: We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined. RESULTS: According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively. CONCLUSION: This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.

Hiperparatiroidismo primario: nuestra experiencia / Primary hiperparathyroidism: our experience

Presentamos nuestra experiencia obtenida entre los años 1954 y 1992 con el tratamiento de 29 enfermos afectados de hiperparatiroidismo primario. Exponemos en todos los enfermos la sintomatología presente, los resultados obtenidos a través de los exámenes de calcio, fósforo y hormona paratiroidea en plasma, y calcio y fósforo en orina, como así también distintas radiografías óseas. Para la ubicación de las glándulas se efectuó, preoperatoriamente, ecografía, centellograma de sustracción adición y tomografía axial computada. La terapéutica efectuada consistió en la resección de los adenomas, la paratiroidectomía de tres glándulas o de tres glándulas y la mitad de la cuarta en las hiperplasias y la resección en bloque del tumor, con el lóbulo tiroideo homolateral, en los cánceres. En el postoperatorio, se siguió clínicamente a los pacientes, con los signos de Trousseau y Chvöstek y calcemia luego de las 24hs., efectuándose calcio intravenoso a los que presentaban hipocalcemia

Hiperparatiroidismo primario: nuestra experiencia / Primary hiperparathyroidism: our experience

Presentamos nuestra experiencia obtenida entre los años 1954 y 1992 con el tratamiento de 29 enfermos afectados de hiperparatiroidismo primario. Exponemos en todos los enfermos la sintomatología presente, los resultados obtenidos a través de los exámenes de calcio, fósforo y hormona paratiroidea en plasma, y calcio y fósforo en orina, como así también distintas radiografías óseas. Para la ubicación de las glándulas se efectuó, preoperatoriamente, ecografía, centellograma de sustracción adición y tomografía axial computada. La terapéutica efectuada consistió en la resección de los adenomas, la paratiroidectomía de tres glándulas o de tres glándulas y la mitad de la cuarta en las hiperplasias y la resección en bloque del tumor, con el lóbulo tiroideo homolateral, en los cánceres. En el postoperatorio, se siguió clínicamente a los pacientes, con los signos de Trousseau y Chv÷stek y calcemia luego de las 24hs., efectuándose calcio intravenoso a los que presentaban hipocalcemia