The ventral hippocampal regulation of prepulse inhibition and its disruption by apomorphine in rats are not mediated via the fornix.

Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is impaired in schizophrenia. We have reported that PPI is regulated by the ventral hippocampus (VH) and that the PPI disruptive effects of the dopamine agonist apomorphine are enhanced 4 weeks after excitotoxic lesions of the VH. The mechanisms responsible for the VH influence on PPI are not understood, but have been ascribed to interactions between the VH and nucleus accumbens. In the present study, we examined whether the VH influence on PPI and its dopaminergic regulation is dependent on the integrity of the VH-accumbens projection via the fornix. First, the PPI-disruptive effects of intra-VH NMDA infusion were assessed after sham or electrolytic transection of the fornix. Second, the PPI-disruptive effects of apomorphine were assessed 1 month after excitotoxic or electrolytic lesions of the VH, or after fornix transection. Intra-VH N-methyl-D-aspartate infusion significantly disrupted PPI; this effect was unaffected by fornix lesions. The PPI-disruptive effects of apomorphine were significantly enhanced by excitotoxic or electrolytic lesions of the VH, but not by fornix transection. The influence of the VH on PPI and its dopaminergic regulation does not appear to be mediated via the fornix. The enhanced sensitivity to the PPI-disruptive effects of apomorphine after VH lesions is not dependent on excitotoxin-induced changes in the VH or its downstream projections.

Diffraction-limited dark laser spot produced by a hollow optical fiber.

By using the diffracted field of the LP(11) mode of a hollow-core optical fiber, we have produced a micrometer-sized, focused dark laser spot in the near field of the fiber. The minimum half-width of the dark spot is less than 1 mum . In particular, by masking the hollow core and metal coating the cladding with a microsphere, we blocked the light propagating in the cladding and obtained a clean dark spot, which may be useful in atom-optical experiments such as with atomic lenses, atom traps, and atom switches.

Atom trap in an axicon mirror.

We have realized a novel atom trap in an axicon (conical hollow) mirror, using a frequency-modulated, single-diode laser. Different spatial distributions of trapped atoms such as a ball and a ring are observed. We show that our numerical simulations are consistent with experimental results. In particular, the ring diameter is found to be approximately the separation between the mirror axis and the magnetic field axis. The axicon trap may be useful as a precooled atom source for cold atomic beams, atom funnels, and atom waveguides.

Single-beam atom trap in a pyramidal and conical hollow mirror.

We present a novel and simple magneto-optical trap in pyramidal and in conical hollow mirrors, using a single beam. A diode laser having modulation sidebands at microwaves is used for cooling, trapping, and repumping of rubidium atoms in a vapor cell. When the laser is circularly polarized and sent into the hollow region, three pairs of counterpropagating beams are automatically produced therein that have the same polarization configuration as that of a conventional six-beam magneto-optical trap. The fluorescence by the trapped atoms and its mirror image are observed simultaneously. This system may be useful for atom-manipulation applications such as gravitational atom traps and atom waveguides.