The prevalence of human papillomavirus 16 and Epstein-Barr virus in patients with oral squamous cell carcinoma.

It has been suggested that certain viruses such as human papillomaviruses (HPV) and Epstein-Barr virus (EBV) might have a role in oral squamous cell carcinoma (OSCC). However, results of the published studies are controversial and are dependent on the geographic distribution and methods of sampling and sample analysis. The aim of this study was to determine the prevalence of HPV 16 and EBV in OSCC patients. In 24 patients with OSCC (mean age 59.6 +/- 8.8) and 30 controls (mean age 49.1 +/- 8.3), 5 mL of blood was collected to determine the prevalence of EBV by serologic methods. In addition, swabs were obtained to analyze the presence of HPV 16 and EBV by use of polymerase chain reaction. Statistical analysis was performed by use of Mann-Whitney test, chi2-test and Spearman correlation test. The results of this study showed that there were no significant differences between OSCC patients and control subjects according to the presence of EBV or HPV 16. Therefore, it can be concluded that the role of the aforementioned viruses is less likely in our population of OSCC patients.

Pain relieve after impacted wisdom teeth extraction dependent on the drug therapy.

Purpose of this study was to compare the effects of combined therapy using nonsteroid anti-inflammatory analgetics and corticosteroids, and the effects of the mono-therapy with same drugs for post-operative pain after surgical removal of the impacted mandibular third molar. The study was completed at the Department of Oral Surgery and at the Department of Dental Medicine of the Public Institute Health Center Zenica in Zenica. The research included 60 patients divided into 3 groups using random selection, including both sexes. Age range was between 18 and 45 years. All participants came without any pain or other inflammatory symptoms at the time of oral surgical intervention. Two medicaments were prescribed after the impacted tooth removal: 15 mg of nonsteroid anti-inflammatory analgesic drug (Meloxicam, Bosnalijek, BiH) and 32 mg Methylprednisolone (corticosteroid, Bosnalijek, BiH). Both medicaments were applied per os, according to schedule determined by the research protocol. The level of post-surgical pain was evaluated by the 1-10 visual analog scale (VAS). One way ANOVA was made with Tuckey post-hoc tests. Statistically significant difference (p < 0.05) was found between the group treated with mono therapy and the group treated with combined therapy. Application of monotherapy using only corticosteroids or only nonsteroid anti-inflammatory pain-killers was less effective compared to the combined therapy with both medicaments after surgical removal of the impacted mandibular third molar.

3-D stress analysis in first maxillary premolar.

The aim of this study was to investigate the stress distribution in a 3-D model of two-rooted tooth (first maxillary premolar) under two different occlusal force vectors by using finite element analysis. In the first model overall force of 200 N was divided into three vectors (cusp to fossa occlusion), and in the second model overall force was divided into 4 vectors (cusp to fossa and cusp to marginal ridge occlusion). The greatest compressive stress was found at the dentino- enamel junction in the cervical area of the both models (about -200 MPa). The greatest tensile stress was found at the vestibular aspect of buccal cusp in second model (about +3 MPa) and in the central fossa of the both models (about +28 MPa). Results indicate that in the both types of occlusal loadings the stress distribution was mainly compression and compressive forces were predominant over tensile stresses. In the second model with 4 vectors, stresses generated in the tooth structure were higher compared to the stresses generated in the first model with 3 vectors.