Reference values of fetal ultrasound biometry: results of a prospective cohort study in Lithuania.

PURPOSE: The aim of the study was to construct a reference range for the Lithuanian population for fetal biparietal diameter (BPD), occipitofrontal diameter (OFD), head circumference (HC), abdominal circumference (AC) and femur length (FL) and to compare them with the old local and current international reference values. METHODS: A prospective cross-sectional study was carried out in secondary referral centres Vilnius University Hospital Santariskiu Klinikos Centro Affiliate in 2008-2009 and Vilnius Maternity Hospital in 2009-2014. The fetal biometry of 556 fetuses between 12 and 42 weeks gestation was performed. BPD, OFD, HC, AC and FL were measured. The data were collected and the analysis was performed using statistical programs MS Excel, SPSS and Matlab. Different regression models were fitted to calculate the mean and standard deviation at each gestational age for each parameter. RESULTS: The biometric measurements of HC, BPD, OFD as well as AC and FL were performed for 556 fetuses. The centile charts, tables and regression formulae of the biometric parameters were constructed. The comparison of the current charts with those of other two studies revealed no significant differences of HC centiles. AC values were similar to those presented in the international study INTERGROWTH-21 and significantly higher in comparison to the study for the Lithuanian population conducted by Alisauskas (1980). FL values, especially in late pregnancy, were significantly smaller in the INTERGROWTH-21 study compared to our charts; however, there were no significant differences of the 50th centile compared to the results from Alisauskas. CONCLUSIONS: We have constructed and presented centile charts, tables and regression formulae for fetal biometry for the Lithuanian population and compared them with the results of two other studies. The significant differences between our centile charts and those from INTERGROWTH-21 imply the necessity to have local standards of fetal biometry, while the differences of our results from the older study in the same population show the importance of updating fetal biometry reference charts for every generation.

Fetal Tibial Artery Doppler in Late IUGR Fetuses: A Longitudinal Study.

INTRODUCTION: Late-onset intrauterine fetal growth restriction (IUGR) is a common pregnancy complication diagnosed in 5-10% of pregnant women worldwide. Under the impact of hypoxia, the fetus develops a protective mechanism of adaptive changes occurring in the cerebral circulation ("brain-sparing effect"). MATERIALS AND METHODS: We conducted detailed longitudinal Doppler examinations and the monitoring of the fetal condition in 53 IUGR fetuses. Doppler measurements of the pulsatility index in the fetal tibial (TA-PI), umbilical (UA-PI), and middle cerebral arteries (MCA-PI) were performed, and the cerebral placental ratio (CPR) was determined on a weekly basis from the 33rd week to the birth. RESULTS: The longitudinal analysis showed a significant increase in the TA-PI. The UA showed a plateau, but no increase was detected near term. The MCA-PI and CPR showed a progressive decrease in values from inclusion to delivery. Our findings indicate that the increase in the TA-PI was the first sign of the aggravating state of the fetus with the changes registered from the 35th week. The parameters of the UA-PI did not show significant changes, while the MCA and CPR became abnormal later from the 37th week. CONCLUSIONS: These observations can serve towards the development of guidelines for detecting the deteriorating signs and intervention timing in IUGR during late pregnancies.

Doppler Ultrasonography of the Fetal Tibial Artery in High-Risk Pregnancy and Its Value in Predicting and Monitoring Fetal Hypoxia in IUGR Fetuses.

Background and Objectives: Intrauterine growth restriction (IUGR) is the term used to describe a fetus whose estimated weight is less than the 10th percentile of its age growth curve. IUGR is the second most common cause of perinatal death. In many cases there is a deficiency in the standardization of optimal management, prenatal follow-up and timing of delivery. Doppler examination is the most sensitive test that can assess the condition of the fetus and indicate fetal intrauterine hypoxia. Numerous studies of the fetal intrauterine state focus on the umbilical artery and the fetal cerebral blood vessels, while the peripheral arteries have so far received insufficient attention. Materials and Methods: We present a case of an IUGR fetus monitored with a non-stress test (NST) and a Doppler examination of the fetal arteries (tibial, umbilical, middle cerebral and uterine) and the ductus venosus. In this case the first early sign of fetal hypoxia was revealed by blood flow changes in the tibial artery. Results: We hypothesize that peripheral vascular changes (in the tibial artery) may more accurately reflect the onset of deterioration in the condition of the IUGR fetus, such that peripheral blood flow monitoring ought to be employed along with other techniques already in use. Conclusion: This paper describes the clinical presentation of an early detection of late IUGR hypoxia and claims that blood flow changes in the tibial artery signal the worsening of the fetus's condition.

The Level of Free Fetal DNA as Precise Noninvasive Marker for Chromosomal Aneuploidies: First Results from BALTIC Region.

Background and objectives: Noninvasive prenatal testing (NIPT), which has been introduced clinically since 2011, uses the circulating cell-free fetal DNA in the maternal blood to evaluate the risk of a chromosomal anomaly. The aim of this study was to examine the effectiveness of NIPT using a single nucleotide polymorphism method. Materials and Methods: A retrospective study was conducted between 2013 and 2019. The Natera Panorama test was used to analyze the risk of trisomies 21, 18, 13, X monosomy, trisomy, and other sex chromosome abnormalities. A positive result of NIPT for aneuploidy was confirmed by invasive testing. Results: 850 women with a singleton pregnancy participated in the study. The median fetal fraction was 9.0%. The fetal fraction was lower in the no-call group (3.1%) compared with the group that received a call (9.1%) (p < 0.001). A positive correlation was determined between the gestational age and the fetal fraction (r = 0.180, p < 0.001). The overall positive predictive value (PPV) of NIPT for trisomy 21 (n = 9), trisomy 18 (n = 3) and XYY syndrome (n = 1) was 100%. Conclusions: The results of present study showed 100% PPV effectiveness of NIPT Panorama test detecting trisomies of 21 and 18 chromosomes, as well as XYY syndrome in the studied cohort. Therefore, NIPT due to its high PPV, significantly reduces the need for invasive testing, thereby reducing the risk of miscarriage and stillbirth.

Postpartum pubic symphysis diastasis-conservative and surgical treatment methods, incidence of complications: Two case reports and a review of the literature.

BACKGROUND: Widening of the pubic joint of more than 10 mm is diagnostic and defined as pubic symphysis diastasis and is considered a complication of vaginal childbirth or pregnancy. As it is a rare pathology (ranging from 1 in 300 to 1 in 30000 pregnancies), no gold standard treatment has been defined. CASE SUMMARY: This study examines two cases, a 27-year-old woman (gravida 1, para 1) and a 32-year-old woman (gravida 2, para 2), who presented to the clinic after uneventful vaginal deliveries. A normal pregnancy with no complications was observed in both patients. Severe pain in the pubic region occurred after labour and was accompanied by complicated locomotion. Pubic symphysis diastasis was confirmed radiologically and bed rest with lateral decubitus positioning was recommended. Oral non-steroidal antiinflammatory drugs were administered to relieve pain exacerbations. The symptoms decreased after treatment. Post-treatment magnetic resonance imaging (MRI) in the first case showed a reduction in symphyseal separation with no signs of osteitis. Three years later the symptoms recurred; MRI examination showed no further symphyseal widening or signs of osteitis. A relapse of symphyseal separation was diagnosed and conservative treatment was re-administered resulting in successful recovery. In the second case, pain recurred when the patient conceived for the second time. This time no benefit following conservative treatment was observed. Persistent pain and complicated locomotion led to scoliotic deformation of the lumbar part of the spine and leg length discrepancy, thus surgical treatment was chosen and internal pubic synthesis was performed. CONCLUSION: Overall, surgical treatment resulting from insufficient conservative treatment showed a high risk of postoperative complications following the treatment of postpartum pubic symphysis diastasis.

Vasa praevia: a case report and literature review.

Background. The aim of this article is to present a rare clinical case of vasa praevia as well as to assess the relevance of the problem by reviewing the latest literature sources. Materials and methods. In this report we present a case of a 33-year-old woman diagnosed with vasa praevia at 33 weeks of pregnancy, after hospitalisation with preterm rupture of membranes following the delivery of a live healthy baby through a lower segment Caesarean section during 33rd week of gestation at Vilnius University Hospital Santariskiu Clinics. We investigated all the documentation of the patient before and after delivery. Results and conclusions. Vasa praevia is a rather rare pathology which is likely to occur during pregnancy, may result in heavy bleeding and be particularly threatening to the fetus life. A timely diagnosis for these women is essential. The gold standard for vasa praevia diagnosis is the fetal ultrasound scan. Vasa praevia pathology is found during the routine second trimester ultrasound check-up. The selection of proper tactics applied during pregnancy care is essential. At the gestational age of 28-32, it is advisable to mature fetal lungs as well as the fetus condition should be investigated by a perinatologist. The mode of delivery is the C-section which tends to reduce the frequency of possible complications.

Nesciuju ir jaunu negimdziusiu moteru krutu turio, kuno dydzio ir pasyviosios mases lyginamasis tyrimas.

A COMPARATIVE STUDY OF BREAST VOLUME BODY SIZE AND PASSIVE BODY MASS IN PREGNANT AND YOUNG NULLIPAROUS WOMEN: The aim. To compare the relation between the changes in the body and breast size in pregnant and young nulliparous women. Materials and methods. In 2008-2009, 82 young nulliparous nineteen-year-old women were examined in Siauliai (Study I). Their body mass and breast size data were compared with the findings obtained from the examination of pregnant women during their first trimester in Vilnius from 2013 to 2015 (Study II). These findings involved longitudinal and transverse dimensions, the volume of various parts of the body, skin folds, breast dimensions, waist, hips, body mass indices, breast volume, and passive body mass. Both studies used standard anthropometric techniques and Martin instruments. The breast volume was calculated according to the formula of Kramer and Dexler (1981). The percentage of the passive body mass (fat tissue) were determined from the skin folds and the subcutaneous adipose tissue according to the formulae of Wilmore and Behnke (1970), and of Siri (1961). The differences between the groups were assessed by Student's t test. The selected reliability level was p < 0.05. Results. The following indicators were found to be statistically significantly higher in the group of pregnant women: chest, waist, hips, breast volume and the waist-hip index. The adipose tissue in pregnant women increased in the upper part of the body, although the relative and absolute passive body weight between the groups differed insignificantly. a comparison of the measurements of primiparous and multiparous young women with the measurements of the nulliparous subjects shows that the multiparous women had a larger amount of fat tissue, while in primiparous and young nulliparous women these indicators were not significantly different. Body size indices of the subgroups of pregnant women with small, medium, and large breasts were higher than those of the young nulliparous with similar measurements. The body size of lean women (below 25 percentile) was higher than that of young nulliparous women in the group of pregnant women. Differences in the body size indices of medium obese women (between 25 and 75 percentiles) were similar to the indicators of medium-sized female breasts in the group of pregnant women. The differences found in obese women (above 75 percentile) were similar to the indices recorded in the women of medium obesity. Conclusions. The passive body mass of pregnant women was accumulating in the upper part of the body. The body mass index in pregnant women was higher than that in nulliparous young women. Over the course of time (the age difference between the studied groups was ~10 years), the female body increases, the topography of the distribution of the adipose tissue changes. Pregnant women's breast volume was significantly higher than that of young nulliparous women. This phenomenon can be explained by pregnant women's higher passive body mass and older age. Keywords: anthropometry, passive body mass, pregnancy, breasts.