RESUMEN
AIMS: To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with fosinopril, enalapril and lisinopril. METHODS: Patients with congestive heart failure (CHF, NYHA Class II-IV) and chronic renal insufficiency (creatinine clearance
Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/farmacocinética , Enalaprilato/farmacocinética , Fosinopril/análogos & derivados , Insuficiencia Cardíaca/metabolismo , Fallo Renal Crónico/metabolismo , Lisinopril/farmacocinética , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Inhibidores de la Enzima Convertidora de Angiotensina/efectos adversos , Inhibidores de la Enzima Convertidora de Angiotensina/sangre , Presión Sanguínea/efectos de los fármacos , Enalaprilato/efectos adversos , Enalaprilato/sangre , Femenino , Fosinopril/efectos adversos , Fosinopril/sangre , Fosinopril/farmacocinética , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/fisiopatología , Humanos , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/fisiopatología , Lisinopril/efectos adversos , Lisinopril/sangre , Masculino , Persona de Mediana Edad , Peptidil-Dipeptidasa A/sangre , Factores de TiempoRESUMEN
A 17-year-old girl with refractory, but nonmalignant, hypertension and hypokalemia is presented. A state of primary hyperreninism and secondary hyperaldosteronism was found to exist, together with a renin-producing Sertoli cell ovarian tumor. Upon removal of the tumor, this patient attained both a normotensive and a normokalemic state. A brief review is given of renal and nonrenal renin-producing tumors.