[Effectiveness of ciprofloxacin in the treatment of hospital infections of the lower respiratory tract]. / Effektivnost' tsiprofloksatsina pri lechenii gospital'nykh infektsii nizhnikh dykhatel'nykh putei.

The efficacy of ciprofloxacin was studied in the treatment of 22 patients with hospital infection of the lower respiratory tract: 10 patients with nosocomial pneumonia, 8 with exacerbation of chronic obstructive bronchitis, 3 with exacerbation of mucoviscidosis and 1 with bronchiectasis. The drug was administered intravenously in a dose of 200 to 400 mg or orally in a dose of 500 to 750 mg twice a day for 6 to 21 days. The clinical and bacteriological efficacies of ciprofloxacin amounted to 90.9 and 86.4 per cent respectively. The treatment failed in 2 patients: 1 with pneumonia due to Streptococcus pneumoniae and 1 with mucoviscidosis and persistence of Pseudomonas aeruginosa. Ciprofloxacin was well tolerated. The side effects were observed in 2 patients and required no discontinuation of the drug use.

[Clinical aspects and treatment of severe Legionnaires' pneumonia]. / Klinika i lechenie tiazheloi legionelleznoi pnevmonii.

The authors provide the reported data on the epidemiology, morphology, clinical picture and treatment of Legionnaires' disease. Demonstrate a wide disease prevalence and note a high percentage of grave patterns of Legionnaires' disease. Stress the necessity of etiological verification of the diagnosis in pulmonary diseases. The possibility of concomitant lung injury by different microorganisms interfering with the diagnosis and instituting a goal-oriented etiotropic therapy (by tetracycline and erythromycin in Legionnaires' disease) is discussed with reference to clinical material. The authors are also concerned with changes in the immune status of patients with the disease under consideration and approaches to their correction.