RESUMEN
Diversely functionalized diaza[5]helicenes have been synthesized starting from 6,9-dichloro-5,10-diaza[5]helicene, which was prepared from a readily available quinoline building block via Wittig reaction followed by photochemical electrocyclization. The helicene skeleton was substituted by a variety of O-, S-, N-, and C-centered nucleophiles using nucleophilic aromatic substitution reactions and palladium-catalyzed reactions like Suzuki coupling and Buchwald-Hartwig aminations. We have determined, using X-ray single-crystal diffraction, the crystal structures of the chloro- and methoxy-substituted diaza[5]helicenes. A resolution strategy based on diastereomeric separation by substitution of the dichloro derivative with a chiral amine has been shown.
Asunto(s)
Aminas/química , Compuestos Policíclicos/química , Compuestos Policíclicos/síntesis química , Catálisis , Cristalografía por Rayos X , Estructura Molecular , Paladio/química , EstereoisomerismoRESUMEN
An efficient route toward the synthesis of symmetrical and unsymmetrical benzo fused tetrathia[7]helicenes substituted with electron donor (ED) and electron acceptor (EA) groups is reported. A common, readily available precursor 1,2- bis-(2-thienyl)benzene was used to synthesize different helicenes through a Wittig reaction, Stille coupling, and modified oxidative photocyclization.
