RESUMEN
Several lipophilic di-alkylated derivatives of propylene amine oxime (PnAO were complexed to 99mTc. Assessment of the 99mTc-PnAO derivatives included biodistribution and qualitative autoradiography. All of the derivatives studied penetrated the intact blood-brain-barrier, with the 99mTc-dibutyl-PnAO complex exhibiting the lowest initial brain uptake while the 99mTc-diethyl-PnAO and the 99mTc-dipropyl-PnAO complexes possessing nearly identical initial brain uptake as compared to 99mTcPnAO. Qualitative autoradiographs revealed significant loss of image resolution with extended time post injection indicative of rapid radiopharmaceutical washout. Although increasing alkyl chain length did not enhance initial brain uptake, the data demonstrates that limited modification of the PnAO ligand structure can be performed without decreasing cerebral uptake of the respective 99mTc complex.
Asunto(s)
Barrera Hematoencefálica/efectos de los fármacos , Compuestos de Organotecnecio/farmacocinética , Oximas/farmacocinética , Animales , Autorradiografía , Encéfalo/metabolismo , Masculino , Ratas , Ratas Sprague-Dawley , Distribución TisularRESUMEN
Ascitic fluid opacification on delayed intravenous contrast computed tomography scans was observed in eight consecutive patients imaged. This apparently common phenomenon may alter both the sensitivity and the specificity of ascitic fluid detection. It may also serve as a diagnostic aid by making nonascitic intra-abdominal fluid collections (ie, pseudocyst and cystic tumor) more apparent.
