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1.
Vector Borne Zoonotic Dis ; 24(8): 510-519, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38949980

RESUMEN

Background: Chagas disease or American trypanosomiasis, caused by Trypanosoma cruzi and vectored by triatomines, affects millions of people worldwide. In endemic countries including Mexico, infections in domestic animals, such as dogs, may affect the risk of human disease when they serve as a source of infection to vectors that subsequently infect humans. Materials and Methods: We conducted a cross-sectional study of 296 dogs from two cities near the northern and southern borders of Mexico: Reynosa, Tamaulipas, and Tuxtla Gutierrez, Chiapas. Infection was measured based on testing of blood using T. cruzi quantitative PCR (qPCR) and up to three antibody detection assays. The StatPak immunochromatographic assay was used to screen samples and the indirect fluorescent antibody (IFA) and multiplex microsphere immunoassay (MIA) tests were used as secondary tests on all samples that screened positive and a subset of negatives. Serologic positivity was defined based on reactivity on at least two independent tests. Results: Of the 280 samples tested for parasite DNA, two (0.7%) were positive, one of which (0.4%) was confirmed as T. cruzi discrete typing unit TcIV. Overall, 72 (24.3%) samples were reactive for T. cruzi antibodies via StatPak of which 8 were also positive using MIA and 2 were also positive using IFA (including one of the PCR-positive dogs). Overall, nine dogs (3.4%) met study criteria of positivity based on either/both serology or PCR tests. Positive dogs were found in both regions of Mexico; five (2.7%) from Reynosa and four (3.6%) from Tuxtla Gutierrez. We found no association between infection status and state of origin, sex, age group, breed group, neighborhood, and whether other pets lived in the home. Conclusion: Our results re-emphasize dogs' utility as sentinels for T. cruzi in Mexico and underscore the need for improved veterinary diagnostic tests and parasite surveillance at the household level in endemic countries.


Asunto(s)
Enfermedad de Chagas , Enfermedades de los Perros , Trypanosoma cruzi , Animales , Perros , Enfermedad de Chagas/veterinaria , Enfermedad de Chagas/epidemiología , Enfermedades de los Perros/epidemiología , Enfermedades de los Perros/parasitología , Trypanosoma cruzi/aislamiento & purificación , Trypanosoma cruzi/genética , México/epidemiología , Estudios Transversales , Masculino , Femenino , Anticuerpos Antiprotozoarios/sangre
2.
Biomedicines ; 12(6)2024 Jun 18.
Artículo en Inglés | MEDLINE | ID: mdl-38927564

RESUMEN

Vitamin D3 or calcitriol (VitD3) has been shown to have anticancer and anti-inflammatory activity in in vitro models and clinical studies. However, its effect on HPV-16-related cancer has been sparsely explored. In this study, we aimed to determine whether monotherapy or combination therapy with cisplatin (CP) reduces tumor growth and affects survival and systemic inflammation. Treatments were administered to C57BL/6 mice with HPV-16-related tumors (TC-1 cells) as follows: (1) placebo (100 µL vehicle, olive oil, orally administered daily); (2) VitD3 (3.75 µg/kg calcitriol orally administered daily); (3) CP (5 mg/kg intraperitoneally, every 7 days); and (4) VitD3+CP. Tumor growth was monitored for 25 days, survival for 60 days, and the neutrophil-to-lymphocyte ratio (NLR) was evaluated on days 1 (baseline), 7, and 14. VitD3+CP showed greater success in reducing tumor volume compared to CP monotherapy (p = 0.041), while no differences were observed between CP and VitD3 monotherapy (p = 0.671). Furthermore, VitD3+CP prolonged survival compared to CP (p = 0.036) and VitD3 (p = 0.007). Additionally, at day 14 the VitD3 and VitD3+CP groups showed significantly lower NLR values than the CP group (p < 0.05, for both comparisons). Vitamin D3 could be a promising adjuvant in the treatment of cervical cancer or solid tumors and deserves further investigation.

3.
Biomed Rep ; 20(6): 100, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38765855

RESUMEN

Clinical data from hospital admissions are typically utilized to determine the prognostic capacity of Coronavirus disease 2019 (COVID-19) indices. However, as disease status and severity markers evolve over time, time-dependent receiver operating characteristic (ROC) curve analysis becomes more appropriate. The present analysis assessed predictive power for death at various time points throughout patient hospitalization. In a cohort study involving 515 hospitalized patients (General Hospital Number 1 of Mexican Social Security Institute, Colima, Mexico from February 2021 to December 2022) with COVID-19, seven severity indices [Pneumonia Severity Index (PSI) PaO2/FiO2 arterial oxygen pressure/fraction of inspired oxygen (Kirby index), the Critical Illness Risk Score (COVID-GRAM), the National Early Warning Score 2 (NEWS-2), the quick Sequential Organ Failure Assessment score (qSOFA), the Fibrosis-4 index (FIB-4) and the Viral Pneumonia Mortality Score (MuLBSTA were evaluated using time-dependent ROC curves. Clinical data were collected at admission and at 2, 4, 6 and 8 days into hospitalization. The study calculated the area under the curve (AUC), sensitivity, specificity, and predictive values for each index at these time points. Mortality was 43.9%. Throughout all time points, NEWS-2 demonstrated the highest predictive power for mortality, as indicated by its AUC values. PSI and COVID-GRAM followed, with predictive power increasing as hospitalization duration progressed. Additionally, NEWS-2 exhibited the highest sensitivity (>96% in all periods) but showed low specificity, which increased from 22.9% at admission to 58.1% by day 8. PSI displayed good predictive capacity from admission to day 6 and excellent predictive power at day 8 and its sensitivity remained >80% throughout all periods, with moderate specificity (70.6-77.3%). COVID-GRAM demonstrated good predictive capacity across all periods, with high sensitivity (84.2-87.3%) but low-to-moderate specificity (61.5-67.6%). The qSOFA index initially had poor predictive power upon admission but improved after 4 days. FIB-4 had a statistically significant predictive capacity in all periods (P=0.001), but with limited clinical value (AUC, 0.639-0.698), and with low sensitivity and specificity. MuLBSTA and IKIRBY exhibited low predictive power at admission and no power after 6 days. In conclusion, in COVID-19 patients with high mortality rates, NEWS-2 and PSI consistently exhibited predictive power for death during hospital stay, with PSI demonstrating the best balance between sensitivity and specificity.

4.
Nutrients ; 16(10)2024 May 14.
Artículo en Inglés | MEDLINE | ID: mdl-38794721

RESUMEN

Cardiovascular disease risk throughout the life course is increased by abnormal blood lipid levels in youth. The dietary glycemic index (GI) and glycemic load (GL) during adolescence might be related to abnormal blood lipids. This study aimed to analyze the association between dietary GI, GL and dyslipidemia in adolescents from two marginalized regions of Chiapas, Mexico. A cross-sectional study was conducted with 213 adolescents. Food intake was assessed using 24 h recalls. The association between dyslipidemia and dietary GI or GL was tested by using logistic regression models. Low HDL-c was the most prevalent risk factor (47.4%), followed by hypertriglyceridemia (25.4%). In this population, overall dietary GI was not associated with dyslipidemia. A high dietary GL was associated with 2.39 higher odds of low HDL-c (95% CI: 1.21-4.74) when compared to low GL. Female adolescents with high dietary GL had 3.20 higher odds of hypertriglyceridemia (95% CI: 1.03-9.88), whereas no association was found for males. No associations were observed between overall dietary GL and total cholesterol or LDL-c. In adolescents from urban and rural communities in Chiapas, a high dietary GL was associated with a detrimental effect on HDL-c. In female adolescents, high GL was associated with hypertriglyceridemia.


Asunto(s)
Dislipidemias , Índice Glucémico , Carga Glucémica , Humanos , Adolescente , Femenino , Masculino , México/epidemiología , Dislipidemias/epidemiología , Dislipidemias/sangre , Estudios Transversales , HDL-Colesterol/sangre , Dieta/efectos adversos , Factores de Riesgo , Hipertrigliceridemia/sangre , Hipertrigliceridemia/epidemiología , Prevalencia , Modelos Logísticos
5.
Rev Soc Bras Med Trop ; 57: e007032024, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38537000

RESUMEN

BACKGROUND: Chagas disease, a zoonosis transmitted mainly by hematophagous insects of the subfamily Triatominae, is caused by Trypanosoma cruzi, classified into six discrete typing units (DTUs: TcI-TcVI and Tcbat). METHODS: Insect vectors were collected from 84 human dwellings in the municipality of Santo Domingo Tehuantepec, Oaxaca, Mexico; 4.76% were infested. DTUs were determined using conventional and nested PCR. RESULTS: The infection rate was 43.6%. All insects were infected with TcI while one specimen showed mixed infection with TcII. CONCLUSIONS: This is the first report of T. cruzi mixed infection in Triatoma phyllosoma, its main vector in the study region.


Asunto(s)
Enfermedad de Chagas , Coinfección , Triatoma , Trypanosoma cruzi , Animales , Humanos , Trypanosoma cruzi/genética , México , Genotipo
6.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;57: e00703, 2024. graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1550683

RESUMEN

ABSTRACT Background: Chagas disease, a zoonosis transmitted mainly by hematophagous insects of the subfamily Triatominae, is caused by Trypanosoma cruzi, classified into six discrete typing units (DTUs: TcI-TcVI and Tcbat). Methods: Insect vectors were collected from 84 human dwellings in the municipality of Santo Domingo Tehuantepec, Oaxaca, Mexico; 4.76% were infested. DTUs were determined using conventional and nested PCR. Results: The infection rate was 43.6%. All insects were infected with TcI while one specimen showed mixed infection with TcII. Conclusions: This is the first report of T. cruzi mixed infection in Triatoma phyllosoma, its main vector in the study region.

7.
Cad Saude Publica ; 39(11): e00024623, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37970940

RESUMEN

This study was aimed to determine the prevalence of cardiovascular risk factors among different sociodemographic groups of adolescents from indigenous communities in Chiapas, Mexico. A cross-sectional prevalence study was performed in urban and rural communities in the Tzotzil-Tzeltal and Selva regions of Chiapas. A sample of 253 adolescents was studied, of whom 48% were girls and 52% were boys. A descriptive analysis of quantitative variables was performed using measures of central tendency and dispersion. The prevalence of cardiovascular risk factors stratified by sex, geographical area, years of schooling, and ethnicity of the mothers was estimated. The prevalence of cardiovascular risk factors was analyzed in relation to the sociodemographic characteristics of the study population. Low HDL-c (51%) was the predominant cardiovascular risk factor. Girls had a higher prevalence of abdominal obesity, hypertriglyceridemia, and borderline total cholesterol than boys. High diastolic blood pressure was more prevalent in boys. Adolescents from urban areas had a higher prevalence of overweight/obesity and insulin resistance than adolescents from rural areas. The prevalence of overweight/obesity and abdominal obesity was higher in adolescents whose mothers had ≥ 7 years of schooling compared with adolescents with less educated mothers. Differences by maternal ethnicity also influenced the prevalence of insulin resistance. Among the main findings, this study associated sociodemographic and geographical inequalities with cardiovascular risk factors. Promoting a healthy lifestyle for this young population is absolutely necessary to prevent cardiovascular diseases in adulthood.


Asunto(s)
Enfermedades Cardiovasculares , Resistencia a la Insulina , Masculino , Femenino , Humanos , Adolescente , Sobrepeso/epidemiología , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , Factores de Riesgo , Obesidad Abdominal/complicaciones , Estudios Transversales , México/epidemiología , Brasil/epidemiología , Obesidad/epidemiología , Factores de Riesgo de Enfermedad Cardiaca , Prevalencia , Índice de Masa Corporal
8.
Vector Borne Zoonotic Dis ; 23(11): 583-587, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37695846

RESUMEN

Background: Triatomine bugs are natural vectors of Trypanosoma cruzi, which causes Chagas disease or American trypanosomiasis. The role of sylvatic triatomine species as vectors of T. cruzi in Mexico remains to be fully understood. Our research on the epidemiology of Chagas disease in Southeastern Mexico involved sampling triatomines in rural settings. Materials and Methods: A triatomine was collected in a peridomestic environment of a rural dwelling in the state of Chiapas. The triatomine was identified morphologically as an adult female Eratyrus cuspidatus Stal. Results: Microscopic analysis revealed flagellate forms of T. cruzi in the feces of the E. cuspidatus collected. This was confirmed by quantitative polymerase chain reaction. Amplification of the mini-exon gene showed that the T. cruzi infecting E. cuspidatus corresponded to lineage I. Conclusions: This is the first report from Mexico of E. cuspidatus found infected in a human dwelling, which represents an important adaptation process to inhabit human environments.


Asunto(s)
Enfermedad de Chagas , Reduviidae , Triatoma , Triatominae , Trypanosoma cruzi , Animales , Adulto , Femenino , Humanos , Trypanosoma cruzi/genética , México/epidemiología , Insectos Vectores , Enfermedad de Chagas/epidemiología , Enfermedad de Chagas/veterinaria
9.
J Diabetes Res ; 2023: 8898958, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36846513

RESUMEN

Diabetes mellitus is a disease with no cure that can cause complications and even death. Moreover, over time, it will lead to chronic complications. Predictive models have been used to identify people with a tendency to develop diabetes mellitus. At the same time, there is limited information regarding the chronic complications of patients with diabetes. Our study is aimed at creating a machine-learning model that will be able to identify the risk factors of a diabetic patient developing chronic complications such as amputations, myocardial infarction, stroke, nephropathy, and retinopathy. The design is a national nested case-control study with 63,776 patients and 215 predictors with four years of data. Using an XGBoost model, the prediction of chronic complications has an AUC of 84%, and the model has identified the risk factors for chronic complications in patients with diabetes. According to the analysis, the most crucial risk factors based on SHAP values (Shapley additive explanations) are continued management, metformin treatment, age between 68 and 104 years, nutrition consultation, and treatment adherence. But we highlight two exciting findings. The first is a reaffirmation that high blood pressure figures across patients with diabetes without hypertension become a significant risk factor at diastolic > 70 mmHg (OR: 1.095, 95% CI: 1.078-1.113) or systolic > 120 mmHg (OR: 1.147, 95% CI: 1.124-1.171). Furthermore, people with diabetes with a BMI > 32 (overall obesity) (OR: 0.816, 95% CI: 0.8-0.833) have a statistically significant protective factor, which the paradox of obesity may explain. In conclusion, the results we have obtained show that artificial intelligence is a powerful and feasible tool to use for this type of study. However, we suggest that more studies be conducted to verify and elaborate upon our findings.


Asunto(s)
Diabetes Mellitus , Hipertensión , Metformina , Humanos , Anciano , Anciano de 80 o más Años , Presión Sanguínea , Metformina/uso terapéutico , Estudios de Casos y Controles , Inteligencia Artificial , Hipertensión/complicaciones , Hipertensión/tratamiento farmacológico , Hipertensión/epidemiología , Factores de Riesgo , Obesidad/complicaciones , Aprendizaje Automático
10.
Clin Investig Arterioscler ; 35(2): 53-63, 2023.
Artículo en Inglés, Español | MEDLINE | ID: mdl-35961839

RESUMEN

BACKGROUND AND AIMS: Triglycerides are the initiators of the metabolic changes that lead to atherogenic dyslipidemia (AD). The APOA5 and APOA1 genes are involved in the response and metabolism of serum lipids and lipoproteins, where single nucleotide polymorphisms (SNP) rs662799 (promoter region) and rs5070 (intronic region) have been associated with the susceptibility to dyslipidemia. Until now, few studies evaluate the association of these polymorphisms with the presentation of hypertriglyceridemia and AD among Mexican children. Therefore, the objective was to determine the association between rs662799 and rs5070 with hypertriglyceridemia and AD in a pediatric population of southeastern Mexico. MATERIALS AND METHODS: A case-control analysis was performed including 268 infants aged 2-16 years, anthropometric, clinical variables, and serum lipid profiles were analyzed. DNA was extracted from blood samples and genotyping of polymorphisms was executed with the TaqMan SNP genotyping assay. Allele and genotypic frequencies were calculated. For genetic association analysis, logistic regression models were fitted according to models of inheritance. RESULTS: The SNP rs662799 (C) was significantly associated with hypertriglyceridemia in the overdominant model (OR=3.89, p=0.001) and AD in the dominant model (OR=4.01, p=0.001). The SNP rs5070 (T) has a protective effect against hypertriglyceridemia in the additive risk model (OR=0.68, p=0.03). CONCLUSION: Polymorphism rs662799 was significantly associated with cases of hypertriglyceridemia and AD in minors in southeastern Mexico. On the other hand, rs5070 polymorphism was not associated with cases of hypertriglyceridemia or AD.


Asunto(s)
Aterosclerosis , Dislipidemias , Hipertrigliceridemia , Humanos , Niño , México , Apolipoproteína A-V/genética , Genotipo , Hipertrigliceridemia/genética , Polimorfismo de Nucleótido Simple , Aterosclerosis/genética , Dislipidemias/genética , Predisposición Genética a la Enfermedad , Frecuencia de los Genes , Triglicéridos
11.
Cad. Saúde Pública (Online) ; 39(11): e00024623, 2023. tab
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1550179

RESUMEN

Abstract: This study was aimed to determine the prevalence of cardiovascular risk factors among different sociodemographic groups of adolescents from indigenous communities in Chiapas, Mexico. A cross-sectional prevalence study was performed in urban and rural communities in the Tzotzil-Tzeltal and Selva regions of Chiapas. A sample of 253 adolescents was studied, of whom 48% were girls and 52% were boys. A descriptive analysis of quantitative variables was performed using measures of central tendency and dispersion. The prevalence of cardiovascular risk factors stratified by sex, geographical area, years of schooling, and ethnicity of the mothers was estimated. The prevalence of cardiovascular risk factors was analyzed in relation to the sociodemographic characteristics of the study population. Low HDL-c (51%) was the predominant cardiovascular risk factor. Girls had a higher prevalence of abdominal obesity, hypertriglyceridemia, and borderline total cholesterol than boys. High diastolic blood pressure was more prevalent in boys. Adolescents from urban areas had a higher prevalence of overweight/obesity and insulin resistance than adolescents from rural areas. The prevalence of overweight/obesity and abdominal obesity was higher in adolescents whose mothers had ≥ 7 years of schooling compared with adolescents with less educated mothers. Differences by maternal ethnicity also influenced the prevalence of insulin resistance. Among the main findings, this study associated sociodemographic and geographical inequalities with cardiovascular risk factors. Promoting a healthy lifestyle for this young population is absolutely necessary to prevent cardiovascular diseases in adulthood.


Resumen: El objetivo de este estudio fue estimar la prevalencia de los factores de riesgo cardiovascular entre diferentes grupos sociodemográficos de adolescentes de comunidades indígenas de Chiapas, México. Se realizó un estudio transversal de prevalencia en comunidades urbanas y rurales de las regiones Tzotzil-Tzeltal y Selva, en Chiapas. Participó una muestra de 253 adolescentes, en la cual el 48% eran niñas y el 52% niños. Se realizó un análisis descriptivo de las variables cuantitativas utilizando medidas de tendencia central y dispersión. Se estimó la prevalencia de los factores de riesgo cardiovascular, estratificados por sexo, área geográfica, nivel de estudios y etnia de las madres. Se analizó la prevalencia de los factores de riesgo cardiovascular con relación a las características sociodemográficas de la población estudiada. El HDL-c bajo (51%) fue el factor de riesgo cardiovascular predominante. Se observó una mayor prevalencia de obesidad abdominal, hipertrigliceridemia y colesterol total en las niñas que en los niños. La alta presión arterial diastólica prevaleció en los niños. Los adolescentes del área urbana tuvieron una mayor prevalencia de sobrepeso/obesidad y resistencia a la insulina que los del área rural. La prevalencia de sobrepeso/obesidad y obesidad abdominal fue mayor en los adolescentes cuyas madres tenían nivel de estudios ≥ 7 años que aquellos cuyas madres tenían bajo nivel de estudios. Las diferencias en la etnicidad materna también influyeron en la prevalencia de resistencia a la insulina. Entre las principales conclusiones de este estudio, se destacan las desigualdades sociodemográficas y geográficas entre los factores de riesgo cardiovascular. La promoción de un estilo de vida saludable entre la población joven es lo indicado para prevenir las enfermedades cardiovasculares en la edad adulta.


Resumo: O objetivo deste estudo foi determinar a prevalência de fatores de risco cardiovascular entre diferentes grupos sociodemográficos de adolescentes de comunidades indígenas em Chiapas, México. Foi realizado um estudo transversal de prevalência em comunidades urbanas e rurais das regiões de Tzotzil-Tzeltal e Selva de Chiapas. Foi estudada uma amostra de 253 adolescentes, sendo 48% meninas e 52% meninos. Foi realizada uma análise descritiva das variáveis quantitativas por meio de medidas de tendência central e dispersão. Foram estimadas as prevalências de fatores de risco cardiovascular, estratificadas por sexo, área geográfica, escolaridade e etnia das mães. A prevalência dos fatores de risco cardiovascular foi analisada em relação às características sociodemográficas da população estudada. O HDL-c baixo (51%) foi o fator de risco cardiovascular predominante. Prevalências mais elevadas de obesidade abdominal, hipertrigliceridemia e colesterol total limítrofe foram mais observadas em meninas do que em meninos. A pressão arterial diastólica elevada prevaleceu nos meninos. Adolescentes da área urbana apresentaram prevalências de sobrepeso/obesidade e resistência à insulina maiores do que os da área rural. A prevalência de sobrepeso/obesidade e obesidade abdominal foi maior nos adolescentes cujas mães possuíam escolaridade ≥ 7 anos do que naqueles indivíduos cujas mães tinham baixa escolaridade. As diferenças de etnia das mães também foram observadas na prevalência de resistência à insulina. Dentre as principais conclusões, foram encontradas, neste estudo, desigualdades sociodemográficas e geográficas entre fatores de risco cardiovascular. Promover estilos de vida saudáveis entre a população jovem é o ideal para prevenir doenças cardiovasculares na vida adulta.

14.
Zookeys ; 1084: 139-150, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35177949

RESUMEN

A wide variety of mammals are involved in the sylvatic cycle of Trypanosomacruzi, the causative agent of Chagas disease. In many areas in Latin America where T.cruzi is endemic, this cycle is poorly known, and its main reservoirs have not been identified. In this study we analyzed T.cruzi infection in bats and other small mammals from an Ecological Reserve in southeastern Mexico. From January through March 2021, we captured wild individuals to extract cardiac and peripheral blood, and infection was detected by PCR of the mini-exon gene. In bats, the prevalence of infection was 16.36%, while in small mammals the prevalence was 28.57%. All of the samples that were positive for T.cruzi were identified as the TCI genotype. Our findings suggest that this zone, situated at the periphery of urban zones might have epidemiological relevance in the sylvatic cycle of T.cruzi and needs to be monitored. The infection of bats in this area is particularly concerning since the flight pattern of this populations overlaps with human settlements. Despite being subject to conservation protections, there continue to be anthropogenic actions that disturb the study area, which could exacerbate risks to public health.

15.
J Physiol Anthropol ; 40(1): 11, 2021 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-34454619

RESUMEN

BACKGROUND: Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas. METHODS: In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components. RESULTS: The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007). CONCLUSIONS: Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.


Asunto(s)
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética , Indígenas Norteamericanos , Síndrome Metabólico , Polimorfismo de Nucleótido Simple/genética , Adulto , Estudios Transversales , Femenino , Humanos , Indígenas Norteamericanos/genética , Indígenas Norteamericanos/estadística & datos numéricos , Síndrome Metabólico/epidemiología , Síndrome Metabólico/genética , México/epidemiología , Persona de Mediana Edad
16.
Cad Saude Publica ; 36(6): e00110519, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32578804

RESUMEN

The proliferation of arboviruses and their vectors is influenced by a complex interplay between vector, environment and human behaviors. The aim of this work is to analyze the influence of socio-environmental determinants on knowledge and practices regarding arboviruses transmission, among the residents of three communities on the southern border of Mexico. Between June 2017 and August 2018, a set of 149 households from three communities of Tapachula (Chiapas) and Villahermosa (Tabasco) were covered. This study consists of the application of a community prevention project. Different surveys and methodological approaches were used. Associations between socio-environmental determinants and knowledge and practices for arboviruses transmission control were estimated by odds ratio. Logistic regression and qualitative techniques were used. Although around 75% of households had an adequate knowledge about arboviruses' origin and transmission, only 30% of them adopted adequate practices. Domestic risk practices were associated with serious deficiencies in water and sanitation services. Furthermore, a perception of greater risk and difficulty in complying with preventive measures were detected. An adequate knowledge does not necessarily lead to adequate prevention practices. Intermediate social determinants influence on the persistence of risk behaviors for arboviruses proliferation. Addressing such related aspects requires the achievement of an effective and sustainable vector management.


Asunto(s)
Aedes , Arbovirus , Fiebre Chikungunya , Dengue , Infección por el Virus Zika , Virus Zika , Animales , Brasil , Dengue/prevención & control , Humanos , México/epidemiología
17.
Int J Public Health ; 65(3): 249-255, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32185417

RESUMEN

OBJECTIVES: The purpose of this study is to analyse the effect of a community participation programme based on the ecosystem model on the incidence of dengue in urban communities. METHODS: A randomized controlled field trial was conducted in the state of Colima, Mexico. The intervention consisted of a community participation programme focused on the ecosystem; simultaneously, the control groups were communities that only received the usual official prevention programs. The incidence of dengue was estimated in people of both groups due to the appearance of de novo IgM antibodies during the follow-up period. RESULTS: The incidence of dengue in the intervened group was 2.58%/month (n = 818) and in control group 2.26%/month (n = 994), with a risk ratio of 1.14 (95% CI 0.89-1.45) and a PAF of 0.06 (95% CI - 0.056 to 0.16). The A. aegypti larval density (Breteau Index) was reduced in the treated group. CONCLUSIONS: The implementation of a community participation programme in the cities of Colima, Mexico, showed a slightly counterproductive effect on the incidence of dengue. This happened even with a reduction in the A. aegypti index.


Asunto(s)
Participación de la Comunidad/métodos , Participación de la Comunidad/estadística & datos numéricos , Dengue/epidemiología , Dengue/prevención & control , Ecosistema , Control de Mosquitos/métodos , Mosquitos Vectores , Población Urbana/estadística & datos numéricos , Adolescente , Adulto , Aedes , Anciano , Anciano de 80 o más Años , Animales , Niño , Preescolar , Ciudades/epidemiología , Femenino , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , México/epidemiología , Persona de Mediana Edad , Adulto Joven
18.
Eur J Clin Nutr ; 74(1): 149-157, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31142827

RESUMEN

BACKGROUND/OBJECTIVES: Intrauterine growth restriction (IUGR) and low-birth-weight (LBW) are determinant factors in the development of metabolic diseases in children and adolescents. To estimate the magnitude of the association between LBW and IUGR with stunting or obesity among adolescents of two indigenous regions of the southern State of Chiapas, Mexico. SUBJECTS/METHODS: We assessed a random sample of 303 adolescents selected from a birth cohort study (2003) conducted in three hospitals serving urban and rural communities of Tzotzil-Tzeltal and Selva regions of Chiapas, Mexico. Sociodemographic and anthropometric data from a sample of adolescents were correlated with their anthropometric data at birth (weight, length for age). Logistic regression models were fitted to estimate odds ratios (OR) with 95% confidence intervals to measure the magnitude of the association among the variables of interest. Models were adjusted for potential confounders. RESULTS: In all, 12% of the sample had LBW and 28.8% IUGR. In total, 29% of adolescents were overweight/obese and 21% were stunted. We found a statistically significant association between IUGR and a lower risk of being overweight/obese. A higher probability for stunting was observed for LBW and IUGR. CONCLUSIONS: Stunting and overweight/obesity prevalence in this population of adolescents was high and was associated with IUGR.


Asunto(s)
Retardo del Crecimiento Fetal , Sobrepeso , Adolescente , Niño , Estudios de Cohortes , Retardo del Crecimiento Fetal/epidemiología , Retardo del Crecimiento Fetal/etiología , Trastornos del Crecimiento/epidemiología , Trastornos del Crecimiento/etiología , Humanos , Recién Nacido , México/epidemiología , Obesidad/epidemiología , Sobrepeso/epidemiología , Prevalencia
19.
Cad. Saúde Pública (Online) ; 36(6): e00110519, 2020. tab
Artículo en Inglés | LILACS | ID: biblio-1100971

RESUMEN

Abstract: The proliferation of arboviruses and their vectors is influenced by a complex interplay between vector, environment and human behaviors. The aim of this work is to analyze the influence of socio-environmental determinants on knowledge and practices regarding arboviruses transmission, among the residents of three communities on the southern border of Mexico. Between June 2017 and August 2018, a set of 149 households from three communities of Tapachula (Chiapas) and Villahermosa (Tabasco) were covered. This study consists of the application of a community prevention project. Different surveys and methodological approaches were used. Associations between socio-environmental determinants and knowledge and practices for arboviruses transmission control were estimated by odds ratio. Logistic regression and qualitative techniques were used. Although around 75% of households had an adequate knowledge about arboviruses' origin and transmission, only 30% of them adopted adequate practices. Domestic risk practices were associated with serious deficiencies in water and sanitation services. Furthermore, a perception of greater risk and difficulty in complying with preventive measures were detected. An adequate knowledge does not necessarily lead to adequate prevention practices. Intermediate social determinants influence on the persistence of risk behaviors for arboviruses proliferation. Addressing such related aspects requires the achievement of an effective and sustainable vector management.


Resumen: La proliferación de los arbovirus y sus vectores está influenciada por la interacción compleja entre vectores, medio ambiente y comportamientos humanos. El objetivo de este estudio es analizar la influencia de los determinantes socioambientales sobre el conocimiento y las prácticas relacionadas con la transmisión de los arbovirus entre los residentes de tres comunidades en la frontera sur de México. Entre junio de 2017 y agosto de 2018, se estudiaron 149 domicilios en las comunidades de Tapachula (Chiapas) y Villahermosa (Tabasco). El estudio tuvo como base la aplicación de un proyecto de prevención comunitaria, utilizando diferentes encuestas y abordajes metodológicos. Se usaron odds ratios para estimar las asociaciones entre determinantes socioambientales y el conocimiento y prácticas para el control de la transmisión de los arbovirus, con el uso de regresión logística y técnicas cualitativas. Cerca de un 75% de los domicilios mostraban conocimiento adecuado sobre el origen y transmisión de los arbovirus, pero solamente un 30% habían adoptado prácticas apropiadas. Las prácticas de riesgo en los domicilios estaban asociadas a deficiencias significativas en los servicios de saneamiento y abastecimiento de agua. Además, se detectó la percepción de un mayor riesgo y de dificultad en adoptar medidas preventivas. El conocimiento adecuado no necesariamente conduce a prácticas preventivas adecuadas. Los determinantes sociales intermedios influencian la persistencia de comportamientos que actúan como factores de riesgo para la proliferación de los arbovirus. La gestión de vectores eficaz y sostenible es necesaria para lidiar con esos aspectos interrelacionados.


Resumo: A proliferação dos arbovírus e seus vetores é influenciada pela interação complexa entre vetores, meio ambiente e comportamentos humanos. O objetivo do estudo é de analisar a influência dos determinantes socioambientais sobre o conhecimento e as práticas relacionados à transmissão dos arbovírus entre os residentes de três comunidades na fronteira sul do México. Entre junho de 2017 e agosto de 2018, foram estudados 149 domicílios nas comunidades de Tapachula (Chiapas) e Villahermosa (Tabasco). O estudo teve como base a aplicação de um projeto de prevenção comunitária, utilizando diferentes inquéritos e abordagens metodológicas. Foram usadas odds ratios para estimar as associações entre determinantes socioambientais e conhecimento e práticas para controle da transmissão dos arbovírus, com o uso de regressão logística e técnicas qualitativas. Cerca de 75% dos domicílios mostravam conhecimento adequado sobre a origem e transmissão dos arbovírus, mas apenas 30% haviam adotado práticas apropriadas. As práticas de risco nos domicílios estavam associadas a deficiências significativas nos serviços de saneamento e abastecimento de água. Além disso, foi detectada a percepção de maior risco e de dificuldade em adotar medidas preventivas. O conhecimento adequado não necessariamente leva a práticas preventivas adequadas. Os determinantes sociais intermediários influenciam a persistência de comportamentos que agem como fatores de risco para a proliferação dos arbovírus. A gestão de vetores eficaz e sustentável é necessária para lidar com esses aspectos interrelacionados.


Asunto(s)
Humanos , Animales , Arbovirus , Aedes , Dengue/prevención & control , Fiebre Chikungunya , Virus Zika , Infección por el Virus Zika , Brasil , México/epidemiología
20.
Poblac. salud mesoam ; 16(2): 48-71, Jan.-Jun. 2019. tab, graf
Artículo en Español | LILACS | ID: biblio-1091664

RESUMEN

RESUMEN. Objetivo: Relacionar los datos de la tasa de mortalidad en la niñez por diarrea y gastroenteritis de presunto origen infeccioso o TMN A(090-099) con el Grado de Cohesión Social (GCS). Métodos: Es un estudio transversal y ecológico para el año 2015. La TMN A(090-099) municipal se calculó con los registros de defunciones del Sistema Nacional en Información en Salud (SINAIS). La aproximación hacia la cohesión social se hizo con base en el Consejo Nacional de Evaluación de la Política de Desarrollo Social (CONEVAL) a través del grado de cohesión social (GCS) municipal. Se calculó una correlación bivariada con la prueba de significancia de Spearman. Se obtuvo la correlación entre la TMN A(090-099) y el GCS. También se hizo un modelo: TMN A(090-099) variable dependiente confrontada con el GCS, el índice de Gini, el índice de rezago social y la no derecho habiencia. Resultados: Existe relación negativa entre el GCS y la TMN A(090-099), con significancia pero débilmente correlacionadas (- 0.320**); la hipótesis se acepta con reservas. El modelo presenta correlación moderada y positiva (R=0.554), la R cuadrada sugiere que el modelo explica casi el 27 % de los casos y el valor Durbin-Watson sugiere que el modelo cubre casi 90 % de los casos estudiados. Discusión: La cohesión social en Chiapas es muy tenue al hacer la aproximación que trató este trabajo. Los datos dan cuenta de que existen municipios con muy alta TMN A(090-099) y baja cohesión social, además de alto grado de rezago social; este escenario predomina, pero es necesario replantear la utilidad del abordaje cualitativo como recomendación encontrada en la literatura.


ABSTRAC. Objective: To relate the information of the childhood rate of mortality due to diarrhea and gastroenteritis of supposed infectious origin or TMN A(090-099) with the social cohesion degree (GCS). Methods: It is a transverse and ecological study for the year 2015. The municipal TMN A(090-099) was calculated with the National System in Health Information (SINAIS) deaths records. The approximation towards the social cohesion was done with the National Council for the Evaluation of the Social Development Policy (CONEVAL) through the municipal Social Cohesion Degree (GCS). A bivariate correlation was calculated with Spearman test. The correlation between the TMN A(090-099) and the GCS was obtained. Also a model was calculated: TMN A(090-099) as the dependent variable confronted with the GCS, Gini's index, social blacklog index and the lack of medical services. Results: A negative relation between the GCS and the TMN TO (090-099) was found, with significant but weakly correlation (-0.320 **); the hypothesis is accepted with reservations. The model presents moderate and positive correlation (R=0.554), the square R suggests that the model explains almost 27 % of the cases, and the Durbin-Watson value suggests that the model covers almost 90 % of the studied cases. Discussion: The social cohesion in Chiapas is very subdued. There are municipalities with very high TMN A(090-099) and lower social cohesion degree besides high social backlog degree; this scene prevails, but is necessary to restate the usefulness of the qualitative boarding as recommendation found in social cohesion literature.


Asunto(s)
Humanos , Lactante , Preescolar , Niño , Cuidado del Niño , Mortalidad Infantil , Causas de Muerte , Cohesión Social , México
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