Surgical treatment of an abnormally positioned right adrenal tumor on segmental caudal vena cava aplasia in two dogs.

Segmental caudal vena cava (CVC) aplasia is a rare congenital vascular anomaly in dogs. Two dogs were diagnosed by CT imaging to have right adrenal tumors with concomitant segmental CVC aplasia. During surgery, a firm connection between the right adrenal gland and CVC was observed in both cases. The adrenal glands were found ventral to the CVC and the adrenal tumor was resected including the vascular wall. CVC venectomy for tumor removal will be required if the right adrenal gland is displaced in dogs with segmental CVC aplasia, even if there is no intravascular invasion.

Synthesis and Glycan-Protein Interaction Studies of Se-Sialosides by 77Se NMR.

To expand the potential of Se-carbohydrates for multifunctional mimicry of sugars, herein we addressed the synthesis of the highly challenging and biologically significant Se-glycosides of sialic acid (Se-sialosides). An α-sialyl selenolate anion generated in situ smoothly reacted with electrophiles to give α-Se-sialosides as single stereoisomers. A Se-sialoside was sequentially incorporated with selenium, producing a triseleno-sialoside. This molecule was used as a 77Se NMR-active handle for studying glycan-protein interaction, revealing different binding profiles of sialic acid binding proteins.

Compartmentalized host spaces accommodating guest aromatic molecules in a chiral way in a helix-peptide-aromatic framework.

A novel host molecular assembly of a free-standing flat nanosheet with compartmentalized spaces was prepared using a bolaamphiphilic peptide composed of two amphiphilic helical peptides and an oligo(naphthaleneethynylene) (ONE) unit at the center of the molecule. The nanosheet possesses void host spaces that can accommodate two mol-equivalent ONE groups to form columns of ONE groups in a right-handed helical way and ONE channels over a long distance. The present molecular system therefore can provide a chiral pore channel for relatively large molecules.

Outcomes associated with treatments for medial, lateral, and multidirectional shoulder instability in dogs.

OBJECTIVES: To describe demographic factors, treatments, and outcomes associated with shoulder instability in dogs. STUDY DESIGN: Multi-center, retrospective cohort study. ANIMALS: Dog (n = 130) with shoulder instability. METHODS: Medical records (October 2007-2010) from 4 hospitals of dogs with shoulder instability were reviewed to document age, breed, weight, and gender, categorize them into diagnosis cohorts of medial (MSI), lateral (LSI), or multidirectional (MDI) instability, determine treatments, and document outcomes. Treatment cohorts were defined as nonsurgical management, radiofrequency-induced thermal capsulorrhaphy (RITC), or shoulder reconstruction. Outcomes based upon clinician reevaluation and owner input >1 year after diagnosis were used to determine success, failure, and complication rates. RESULTS: Most dogs were diagnosed with MSI, but 23% had LSI or MDI. Dogs with MSI treated by reconstruction were more likely than dogs treated without surgery to have a successful outcome (odd's ratio = 3.0; P = .01). Similarly, treatment of MDI with reconstruction was more likely to be associated with a successful outcome than nonsurgical management (odd's ratio = 5.0; P = .007). Success with surgical and nonsurgical management was equivocal between LSI treatment cohorts, but the number of dogs with LSI was small. Complication rates for all treatment cohorts were <10%. CONCLUSIONS: In dogs with shoulder instability, LSI and MDI are less common than MSI. Surgical reconstruction for treatment of MSI and MDI appears to produce a higher likelihood of achieving successful outcomes than nonsurgical management and surgical complication rates were low but these conclusions are tempered by the limitations of the study.