Reassessing the multiple values of lowland British floodplains.

Ecosystem services provided by lowland British floodplains respectively under semi-natural conditions and converted for intensive maize production were assessed. Floodplains across lowland Britain have been extensively disconnected from river channels, depleting habitat for wildlife and other beneficial ecosystem services. Conservation measures are often regarded as costly constraints on economic and development freedoms whilst, conversely, conversion for intensive agricultural production is rewarded by markets despite many often-overlooked externalities. Maize growing has increased in Britain since the 1970s, initially for feedlot production of livestock and now increasingly for grant-aided biofuel production for anaerobic digestion. Comparative literature-based ecosystem service assessments using the RAWES (Rapid Assessment of Wetland Ecosystem Services) approach reveal that lowland British floodplains in semi-natural condition provide a wider range of provisioning services than those converted for monocultural intensive production of maize, in addition to a diversity of regulating, cultural and supporting service benefits that are lost or transformed into disservices when floodplains are converted for intensive maize growth. Benefits and disbenefits of floodplains managed under the two scenarios (semi-natural versus monocultural maize) are presented graphically as an intuitive means to support decision-makers. Monetisation of benefits would be risky, not merely due to uncertainties but as this may skew conclusions and subsequent decision-making towards maximisation of marketed or near-market services, consequently misrepresenting the diversity of values of whole socioecological floodplain systems. Management solutions protective of the societal values provided by floodplain ecosystem may include buffer zoning as a mitigation measure, but a more strategic solution may be zonation of land use based on suitability not only for crop production but recognising the full spectrum of societally beneficial ecosystem services demonstrated by RAWES assessment. A variety of drivers for a changing approach to floodplain farming - statutory, fiscal and self-beneficial - are highlighted, and are generically applicable beyond Britain with context-specific modification.

Immune cytopenia post-cord transplant in Hurler syndrome is a forme fruste of graft rejection.

Umbilical cord blood (UCB) is the preferred donor cell source for children with Hurler syndrome undergoing transplant, and its use has been associated with improved "engrafted survival" rates. However, as in other pediatric recipients of UCB transplants for nonmalignant disease, immune-mediated cytopenia (IMC) is a significant complication. This article describes 8 episodes of IMC in 36 patients with Hurler syndrome undergoing UCB transplant. The incidence of IMC was increased in those with a higher preconditioning absolute lymphocyte count and in those conditioned with fludarabine-containing regimens rather than cyclophosphamide, and it included red cell alloantibodies directed at cord blood group antigens that are novel to the recipient. In several cases, IMC was a precursor to immune-mediated complete graft rejection. We describe IMC as part of a spectrum of graft rejection by a residual competent host immune system and a forme fruste of complete graft rejection.