RESUMEN
The world has witnessed massive and preeminent microplastics (MPs) pollution in water bodies due to the inevitable continuous production of plastics for various advantageous chemical and mechanical features. Plastic pollution, particularly contamination by MPs (plastic particles having a diameter lesser than 5 mm), has been a rising environmental concern in recent years due to the inappropriate disposal of plastic trash. This study presents the recent advancements in different technologies for MPs removal in order to gain proper insight into their strengths and weaknesses, thereby orchestrating the preparation for innovation in the field. The production, origin, and global complexity of MPs were discussed. This study also reveals MPs' mode of transportation, its feedstock polymers, toxicities, detection techniques, and the conventional removal strategies of MPs from contaminated systems. Modification of conventional methods vis-à-vis new materials/techniques and other emerging technologies, such as magnetic extraction and sol-gel technique with detailed mechanistic information for the removal of MPs are presented in this study. Conclusively, some future research outlooks for advancing the MPs removal technologies/materials for practical realization are highlighted.
Asunto(s)
Aguas Residuales , Contaminantes Químicos del Agua , Microplásticos , Plásticos , Eliminación de Residuos Líquidos/métodos , Agua , Contaminantes Químicos del Agua/análisis , Monitoreo del AmbienteRESUMEN
Concerned organizations and individuals are fully engaged in seeking appropriate measures towards managing Severe Acute Respiratory Syndrome Coronavirus 2 (SAR-CoV-2) infection because of the unprecedented economic and health impact. SAR-CoV-2 Main protease (SARS-CoV-2 Mpro) is unique to the survival and viability of the virus. Therefore, inhibition of Mpro can block the viral propagation. Thirty (30) derivatives were built by changing the glucosides in the Meta and para position of quercetin and isohamnetin. Molecular docking analysis was used for the screening of the compounds. Dynamics simulation was performed to assess the stability of the best pose docked complex. Molecular mechanics binding free energy calculation was done by Molecular Mechanics/Poisson-Boltzmann Surface Area (MMPBSA). Overall analysis showed that the compounds are allosteric inhibitors of SARS-CoV-2 Mpro. Dynamic simulation analysis established the stability of Mpro-ISM-1, Mpro-ISD-3, Mpro-IST-2, Mpro-QM-2, and Mpro-QD-6 complexes with a maximum of 7 hydrogen bonds involved in their interaction. The MMPBSA binding free energies for ISM-1, ISD-3, IST-2, QM-2, and QD-6 were -92.47 ± 9.06, -222.27 ± 32.5, 180.72 ± 47.92, 156.46 ± 49.88 and -93.52 ± 48.75 kcal/mol respectively. All the compounds showed good pharmacokinetic properties, while only ISM-1 inhibits hERG and might be cardio-toxic. Observations in this study established that the glucoside position indeed influenced the affinity for SARS-CoV-2 Mpro. The study also suggested the potentials of ISD-3, QM-2 and QD-6 as potent inhibitors of the main protease, further experimental and clinical studies are however necessary to validate and establish the need for further drug development processes. Therefore, future studies will be on the chemical synthesis of the compounds and investigation of the in-vitro inhibition of SARS-CoV-2.