RESUMEN
We experienced a case of small cell carcinoma of the stomach in which chemotherapy had been markedly effective. A 54-year-old man was admitted to our hospital complaining of hematemesis. Gastric endoscopy showed a type 2 tumor at the lesser curvature of the cardia of the remnant stomach. Total gastrectomy, splenectomy and D2 lymph node dissection were performed. Histopathologically, the tumor was diagnosed as a small cell carcinoma with findings of t 2 n 1 in stage II, and conclusive curability was A. A month after the operation, CT-scan revealed multiple liver and lung metastases, so the patient was treated by combined chemotherapy with cisplatin and etoposide called PVP for three courses every four weeks for small cell lung cancer, which resulted in remarkable reduction of metastases (96% in the liver and 81% in the lung). This result suggests that PVP chemotherapy is effective in the treatment of small cell carcinoma of the stomach as well as the lung.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Células Pequeñas/tratamiento farmacológico , Neoplasias Hepáticas/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Gástricas/tratamiento farmacológico , Carcinoma de Células Pequeñas/secundario , Carcinoma de Células Pequeñas/cirugía , Cisplatino/administración & dosificación , Terapia Combinada , Etopósido/administración & dosificación , Gastrectomía , Humanos , Neoplasias Hepáticas/secundario , Neoplasias Pulmonares/secundario , Escisión del Ganglio Linfático , Masculino , Persona de Mediana Edad , Esplenectomía , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugíaRESUMEN
Inflammatory pseudotumor of the spleen in a 50-year-old man was encountered in our surgical clinic. This splenic tumor is very rare and in the ninth of the cases in the literature. The removed spleen, weighting 255g, revealed the presence of a firm, circumscribed mass, measuring 4.5 x 4.0 x 4.5 cm, and histologically presenting marked lamination of collagen fibers around the small vessels associated with granulomatous lesions. The implications of its pathogenesis was analyzed with a review of the literature.
Asunto(s)
Granuloma de Células Plasmáticas , Enfermedades del Bazo , Granuloma de Células Plasmáticas/epidemiología , Granuloma de Células Plasmáticas/patología , Granuloma de Células Plasmáticas/cirugía , Humanos , Masculino , Persona de Mediana Edad , Bazo/patología , Enfermedades del Bazo/epidemiología , Enfermedades del Bazo/patología , Enfermedades del Bazo/cirugíaAsunto(s)
Mucosa Intestinal/enzimología , Intestino Delgado/trasplante , Daño por Reperfusión/enzimología , ATPasa Intercambiadora de Sodio-Potasio/metabolismo , Alopurinol/farmacología , Animales , Perros , Radicales Libres , Mucosa Intestinal/irrigación sanguínea , Mucosa Intestinal/trasplante , Intestino Delgado/irrigación sanguínea , Intestino Delgado/enzimología , Microvellosidades/enzimología , Microvellosidades/patología , Daño por Reperfusión/fisiopatologíaAsunto(s)
6-Cetoprostaglandina F1 alfa/sangre , Acrilatos/farmacología , Inhibidores de la Ciclooxigenasa , Rechazo de Injerto , Metacrilatos/farmacología , Trasplante de Páncreas , Tromboxano B2/sangre , Animales , Ciclosporinas/uso terapéutico , Perros , Rechazo de Injerto/efectos de los fármacos , Terapia de Inmunosupresión , Insulina/sangre , Islotes Pancreáticos/efectos de los fármacos , Islotes Pancreáticos/metabolismo , Trasplante de Islotes Pancreáticos , Trasplante HomólogoRESUMEN
Intrahepatic arterial infusion chemotherapy (HAI) was performed for 20 hepatocellular cancer (HCC) patients and 7 cholangiocellular cancer (CC) patients. HAI combined transcatheter arterial embolization (TAE) and/or hyperthermia were performed for 10 HCC and 3 CC patients. The effective responses were shown in 6 HCC and 1 CC patients who were treated with HAI-TAE-hyperthermia combination therapy, and 2 CC patients who were treated with HAI-hyperthermia combination therapy. The 1 and 2-year cumulative survival rate was 100% and 33.3%, respectively, for HCC patients treated with HAI-TAE-hyperthermia therapy. The 1 and 2-year survival rate for HCC patients treated with HAI therapy was 19.5%, and 7.3%, respectively. Generalized Wilcoxon test revealed that the survival was favorable for patients treated with HAI-TAE-hyperthermia therapy as compared with patients given with HAI therapy. Almost the same results were obtained in CC patients. These results suggest that the HAI-TAE-hyperthermia combination therapy was favorable for the treatment of advanced liver cancer.