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Metab Brain Dis ; 32(1): 87-95, 2017 02.
Artículo en Inglés | MEDLINE | ID: mdl-27491636

RESUMEN

Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes has been reported to exert cognitive enhancing potential with limited scientific basis. Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities in cadmium (Cd)-induced memory impairment in rats. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25 mg/kg. Rats received Cd (2.5 mg/kg) and curcumin (12.5 and 25 mg/kg, respectively) by gavage for 7 days. The results of this study revealed that cerebral cortex AChE and ADA activities were increased in Cd-poisoned rats, and curcumin co-treatment reversed these activities to the control levels. Furthermore, Cd intoxication increased the level of lipid peroxidation in cerebral cortex with a concomitant decreased in functional sulfuhydryl (-SH) group and nitric oxide (NO), a potent neurotransmitter and neuromodulatory agent. However, the co-treatment with curcumin at 12.5 and 25 mg/kg, respectively increased the non-enzymatic antioxidant status and NO in cerebral cortex with a decreased in malondialdehyde (MDA) level. Therefore, inhibition of AChE and ADA activities as well as increased antioxidant status by curcumin in Cd-induced memory dysfunction could suggest some possible mechanism of action for their cognitive enhancing properties.


Asunto(s)
Inhibidores de la Adenosina Desaminasa/farmacología , Compuestos de Cadmio , Inhibidores de la Colinesterasa/farmacología , Curcumina/farmacología , Trastornos de la Memoria/tratamiento farmacológico , Memoria Episódica , Memoria Espacial/efectos de los fármacos , Sulfatos , Acetilcolinesterasa/metabolismo , Adenosina Desaminasa/metabolismo , Inhibidores de la Adenosina Desaminasa/uso terapéutico , Animales , Corteza Cerebral/efectos de los fármacos , Corteza Cerebral/enzimología , Inhibidores de la Colinesterasa/uso terapéutico , Curcumina/uso terapéutico , Masculino , Malondialdehído/metabolismo , Trastornos de la Memoria/inducido químicamente , Trastornos de la Memoria/enzimología , Ratas
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