Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A systematic review.

The present systematic review sought to evaluate the effects of Sodium Lauryl Sulfate (SLS)-free compared to SLS-containing dentifrices on (Recurrent) aphthous stomatitis (RAS) in patients with this condition. Cochrane, Medline (PubMed) and Embase databases, and some trial registries were searched through December 2017. There was no language, nor publication year restrictions. We included double-blinded randomized controlled trials that compared the effects of dentifrices with and without SLS on RAS in humans. Data extraction was compliant with PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. PROSPERO 2018:CRD42018086001. Four trials were included in this review (all crossover studies; n = 124 participants) and two contributed to the main meta-analysis based on the random-effect model. SLS-free dentifrice, when compared to SLS-containing statistically significantly, reduced the number of ulcers, duration of ulcer, number of episodes, and ulcer pain. Sensitivity analysis of the four studies as parallel-group trials shows a consistent direction of effect in favor of SLS-free dentifrice usage. In conclusion, the qualitative and quantitative synthesis of the eligible trials for this review showed that use of SLS-free consistently reduced all four parameters of ulcers measured. The available evidence suggests that patients with RAS may benefit from using SLS-free dentifrices for their daily oral care. However, future well-designed trials are still required to strengthen the current body of evidence.

Choriostoma of the gingivae following trauma: an unusual case in a Nigerian with review of relevant literature

Objective: Chondromas are benign intraosseous cartilaginous tumors composed of mature hyaline cartilage; they may however arise from the soft tissue in rare cases without bone or joint involvement and are called extra skeletal or soft tissue chondromas. Extra skeletal chondromas (ESC) are commonly seen in the hands and feet but rarely in the oral cavity. We report a rare case of extra skeletal chondroma of the gingiva in a 31-year-old male patient following trauma to the anterior maxillary soft and hard tissues.Case Description: This is a case of a 31year old hypertensive patient with 3weeks history of gingival swelling in relation to the upper incisors which were fractured following an injury sustained from a motorbike fall. Clinical examination revealed a firm, non-tender localized gingival enlargement adjacent to the palatal surfaces of the maxillary incisors which had a lobulated appearance, with areas of inflammation that bled on gentle probing. The palatal gingival swelling was excised under local anesthesia, while gingivoplasty was performed on the labial gingiva of the same teeth. A periodontal dressing was placed on the surgical sites and removed at one-week review. Histopathologic examination of the palatal swelling revealed connective tissue that was densely infiltrated by mixed inflammatory cells. In some areas, there was focal chondroid tissue with chondrocytes of varying sizes in a chondromyxoid matrix.Conclusion: A rare case of extra skeletal chondroma is reported, we encourage report of more cases with long term follow-up in multicenter study among Nigerians, to ascertain the prevalence, gender, site of ESC in this population

Effect of Calcium Channel Blockers on Gingival Tissues in Hypertensive Patients in Lagos, Nigeria: A Pilot Study.

BACKGROUND: Long-term treatment of common chronic cardiac conditions such as hypertension with calcium channel blockers (CCBs) has long been associated with gingival hyperplasia. This oral side effect may affect esthetics and function, yet often overlooked and therefore underreported among Nigerians. AIM: This study aimed to determine the association of CCBs with gingival overgrowth (GO) in hypertensive patients. METHODS: This was a hospital-based, case-control study conducted among 116 hypertensive patients (58 CCB and 58 non-CCB age-matched controls) attending the medical outpatient clinic of a tertiary health institution in Lagos, Nigeria. Data collection tools included interviewer-administered questionnaires and periodontal examination. Sociodemographic details, medical history, and periodontal indices (gingival index, plaque index, class of GO according to drug-induced GO [DIGO] Clinical Index) were recorded. RESULTS: The mean age was 59.4 ± 12.6 years, females representing 50.9%. In the CCB group, 39 (67.2%) participants were on amlodipine and 19 (32.8%) were on nifedipine. The mean duration of CCB use was 55.6 ± 53 months. DIGO was higher in CCB (36.2%) than that in non-CCB participants (17.2%) (χ2 = 4.4, P = 0.036). The risk of GO was higher in CCB users (odds ratio [OR] 2.7, [95% confidence interval (CI)]: 1.1-6.5). Amlodipine users had higher DIGO (37.5%) than that of nifedipine users (21.1%) (OR 2.3, [95% CI]: 1.0-5.3). The predominant class of DIGO among the CCB users was Class 2 DIGO Clinical Index (90.5%). CONCLUSION: The study reveals that the risk of GO is nearly three times in CCB than that of non-CCB users and twice higher in amlodipine than nifedipine users in Nigeria.