[Features of the appeal for pediatric otorhinolaryngological care in conditions of increased biological risks].

The combined effect of close contact between child patients and otorhinolaryngologists, as well as the practice of aerosol-generating procedures, justify the need to take prompt organizational measures to reduce risks in the provision of pediatric otorhinolaryngological care in conditions of increased biological risks. In the pediatric ENT community, these adaptations have resulted in: judicious distribution of care to treat the most severe conditions, minimizing the risk of long-term consequences, ensuring the safety of child patients and healthcare workers through better communication methods, changing procedural precautions, the rapid introduction of telemedicine for diagnosis and treatment of patients, as well as the development of protective protocols to limit exposure to aerosol-generating procedures or manipulations to reduce the risk of exposure to a high viral load.

[Organization of children's otorhinolaryngological care in conditions of biological risks: international experience].

The COVID-19 pandemic has spurred the introduction of new devices and technologies into the organization of otorhinolaryngological care, the development of safety measures and clinical work protocols in order to increase the safety of doctors and patients. Virtual outpatient clinics have been integrated into the pediatric and basic outpatient services, the potential of which for pediatric otolaryngology is considered quite significant. In otorhinolaryngological practice, the transition to the expanded use of telemedicine technologies (individual gadgets for examining ENT patients, including a direct access otoscope connected to an otolaryngologist's computer) was especially significant. The practice of pediatric ENT services tends to combine virtual and face-to-face visits, even after the acute phase of the COVID-19 pandemic. When organizing otorhinolaryngological care, it is necessary to pay special attention to dialogic consensus - an inclusive and reflective dialogue between a doctor and a patient.

[The effect of the components of general anesthesia on the level of carcinoembryonic antigen in the blood serum of patients with cancer of the large intestine]. / Vliianie komponentov obshchei anestezii na uroven rakovo-émbrionalnogo antigena v syvorotke krovi bolnykh rakom tolstoi kishki.

The effect of calipsol and thiopental (the most frequent drugs used for basis anesthesia), as well as their combinations with narcotic analgesics fentanyl, morphine, promedole and a neuroleptic droperidol on the level of carcinoembryonic antigen (CEA) in patients with colonic cancer has been studied. A significant effect of anesthetics on CEA level in the postoperative period has been established. The lowest CEA level was observed when calipsol, morphine, and promedole were used as components of narcotic analgesics.

[The importance of personality and sociopsychological factors in the development of chronic alcoholism]. / Znachenie lichnostnykh i sotsial'no-psikhologicheskikh faktorov v razvitii khronicheskogo alkogolizma.

An analysis of personality and sociopsychological factors in 102 male chronic alcoholism revealed that persons with hysteroid features show a more early alcohol addiction, more rapid formation of symptoms of chronic alcoholism with frequent recurrences and short remissions indicating a more malignant course of the disease.

[Excretory function of the liver with an allyl alcohol lesion and the antioxidant correction of the disorders]. / Ekskretornaia funktsiia pecheni pri porazhenii allilovym spirtom i korrektsiia narushenii antioksidantami.

In experiments on 33 albino male rats it was established that during allyl alcohol-induced damage of the liver its excretory function is impaired that was judged by the biliary excretion of intravenously injected Bengal pink-131I. Antioxidants (tocopherol acetate, sodium selenite, unithiol) reduced the toxic effect of allyl alcohol on the liver.

[Effect of cyclophosphane on bile formation and lipid peroxidation in the liver]. / Vliianie tsiklofosfana na zhelcheobrazovanie i perekisnoe okislenie lipidov v pecheni.

In experiments on male albino rats cyclophosphamide (100-250 mg/kg) was shown to produce a hepatic lesion presented with the increase in the activity of alanine- and aspartate aminotransferase of blood serum, and the inhibition of secretion of bile, bile acids and bilirubin. In addition, the drug possesses prooxidant properties: at the doses of 10-250 mg/kg it promotes an increase in the content of malon dialdehyde and diene conjugates in the liver, kidneys, myocardium and lungs. The prooxidant properties of cyclophosphamide were suggested to play an important role in its toxicity.

[Effect of cyclophosphane on lipid peroxidation]. / Vliianie tsiklofosfana na perekisnoe okislenie lipidov.

Single and repeated treatment with toxic doses of cyclophosphamide was shown to activate peroxidation of lipids of myocardial, pulmonary, hepatic and renal cell membranes. An antioxidant-silymarin-inhibited the prooxidating effect of cyclophosphamide thus suggesting further studies of antioxidants as means for counteracting the adverse effects of cytostatic drugs.